Consists of Ca lactate, Ca pantothenate, cupric sulfate, Fe fumarate, folic acid, K iodide, niacinamide, Vit A, vit B1, vit B12, vit B2, vit B6, vit C, vit D
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Ca lactate/Ca pantothenate/cupric sulfate/Fe fumarate/folic acid/K iodide/niacinamide/Vit A/vit B1/vit B12/vit B2/vit B6/vit C/vit D Dosage |
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Consists of Ca lactate, Ca pantothenate, cupric sulfate, Fe fumarate, folic acid, K iodide, niacinamide, Vit A, vit B1, vit B12, vit B2, vit B6, vit C, vit D
1 caplet daily.
1 cap daily.
Applies to the following strength(s): 1 mg; 0.4 mg; 5 mg/mL; 0.8 mg
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1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.
400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Infant:
0.1 mg orally, intramuscularly, subcutaneously or IV once a day.
Child:
Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.
4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.
Recommended daily allowance (RDA):
Premature neonates: 50 mcg/day (15 mcg/kg/day).
Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.
Children:
1 to 3 years: 150 mcg/day.
4 to 8 years: 200 mcg/day.
9 to 13 years: 300 mcg/day.
14 years and older: 400 mcg/day.
Data not available
Data not available
Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.
Folic acid is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.
Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.
The recommended daily allowance of folic acid for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.
There is a potential danger in administering folic acid to patients with undiagnosed anemia, since folic acid may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.
Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.
The dosages of other medications you take may need to be changed while you are taking folic acid.
Tell your doctor about all other medications you use, especially:
phenytoin (Dilantin);
methotrexate (Rheumatrex, Trexall);
nitrofurantoin (Macrodantin, Macrobid);
pyrimethamine (Daraprim);
tetracycline (Ala-Tet, Brodspec, Sumycin);
a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or
seizure medication such as phenytoin (Dilantin) or primidone (Mysoline).
This list is not complete and there may be other drugs that can interact with folic acid. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.
Applies to the following strengths: 100 mg; 500 mg
Recommended Daily Allowances (RDA):
Males: 19 mg orally each day
Females: 13 mg orally each day
Initial dose: 100 mg orally 3 times a day, with or after meals
Maintenance dose: 100 to 500 mg orally up to 3 times a day, with or after meals
Niacinamide has toxic potential at adult doses in excess of 3 g/day.
Niacinamide may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for adults contain 40 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients 11 years and older requiring parenteral vitamins.
Recommended Daily Allowances (RDA):
Males: 19 mg orally each day
Females: 13 mg orally each day
Initial dose: 100 mg orally 3 times a day, with or after meals
Maintenance dose: 100 to 500 mg orally up to 3 times a day, with or after meals
Niacinamide has toxic potential at adult doses in excess of 3 g/day.
Niacinamide may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for adults contain 40 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients 11 years and older requiring parenteral vitamins.
Recommended Daily Allowances (RDA):
0 to 6 months: 5 mg orally each day
6 months to 1 year: 6 mg orally each day
1 to 3 years: 9 mg orally each day
4 to 6 years: 12 mg orally each day
7 to 10 years: 13 mg orally each day
Males:
11 to 14 years: 17 mg orally each day
15 to 18 years: 20 mg orally each day
19 to 50 years: 19 mg orally each day
Females:
11 to 50 years: 13 mg orally each day
Niacinamide may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for children contain 17 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients under 11 years of age.
Recommended Daily Allowances (RDA):
0 to 6 months: 5 mg orally each day
6 months to 1 year: 6 mg orally each day
1 to 3 years: 9 mg orally each day
4 to 6 years: 12 mg orally each day
7 to 10 years: 13 mg orally each day
Males:
11 to 14 years: 17 mg orally each day
15 to 18 years: 20 mg orally each day
19 to 50 years: 19 mg orally each day
Females:
11 to 50 years: 13 mg orally each day
Niacinamide may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for children contain 17 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients under 11 years of age.
Data not available
Because niacinamide is primarily metabolized by the liver and because of the risk of hepatotoxicity, niacinamide in not recommended in patients with liver dysfunction.
Data not available
Taking niacinamide with food may reduce stomach upset.
Niacinamide should not be taken with hot drinks.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Childn 7-12 yr 15 mL, 3-6 yr 10 mL, 1-2 yr 5 mL. To be taken once daily.
Vit E increases absorption of vit A. Inhibits absorption & function of vit K w/ high doses of vit E. Reduced effects of vit E w/ Fe prep. Reduced absorption of vit A & E w/ cholestyramine & liqd paraffin.
This medication administered orally, IM, IV, intravaginally.
For the prevention of deficiency conditions Vit C dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.
For intravaginal used ascorbic acid drugs in appropriate dosage forms.
In an application with barbiturates, primidone increases the excretion of ascorbic acid in the urine.
With the simultaneous use of oral contraceptives reduces the concentration of ascorbic acid in blood plasma.
In an application of Vit C with iron preparations ascorbic acid, due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.
Ascorbic acid in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.
With the simultaneous use of aspirin reduces the absorption of ascorbic acid by about a third.
Vit C in an application with warfarin may decrease effects of warfarin.
With the simultaneous application of ascorbic acid increases the excretion of iron in patients receiving deferoxamine. In the application of ascorbic acid at a dose of 500 mg / day possibly left ventricular dysfunction.
In an application with tetracycline is increased excretion of ascorbic acid in the urine.
There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with ascorbic acid 500 mg 2 times / day.
May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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