Calcitriol Airflow Side effects

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What are the possible side effects of Calcitriol Airflow?

Get emergency medical help if you have any of these signs of an allergic reaction to Calcitriol Airflow: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Calcitriol Airflow and call your doctor at once if you have any of these serious side effects:

  • blistering, or severe redness, itching, or other irritation of treated areas; or

  • worsened symptoms or no improvement in psoriasis.

Using Calcitriol Airflow can affect your body's ability to metabolize calcium. This can result in high levels of calcium in your blood (hypercalcemia). Symptoms of this condition include nausea, constipation, loss of appetite, increased thirst and urination, muscle weakness, confusion, and feeling tired or restless. Call your doctor if you have any of these symptoms.

Less serious Calcitriol Airflow side effects may include mild itching or skin discomfort.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Calcitriol Airflow in details

infoA side effect of any drug can be defined as the unwanted or undesired effect produced by the drug. The side effect can be major or in few medications minor that can be ignored. Side effects not only vary from drug to drug, but it also depends on the dose of the drug, the individual sensitivity of the person, brand or company which manufactures it. If side effects overweigh the actual effect of the medicine, it may be difficult to convince the patient to take the drug. Few patients get specific side effects to specific drugs; in that case, a doctor replaces the drug with another. If you feel any side effect and it troubles you, do not forget to share with your healthcare practitioner.

Adverse Drug Reaction Overview

The following adverse reactions have been reported in association with Calcitriol Airflow® (Calcitriol Airflow injection) treatment.

The most frequently reported adverse effect is hypercalcemia (35% approximately after the 4th week of treatment).

The less frequently reported adverse effects were headache, nausea, vomiting, constipation, abdominal cramp, pruritis, conjunctivitis, agitation, extremity pain, apprehension, polyuria, insomnia, elevated serum glutamic oxaloacetic transaminase (SGOT) and/or serum glutamic pyruvic transaminase (SGPT), elevated alkaline phosphatase, hypercalciuria, hypermagnesemia, hyperphosphatemia, elevated lymphocytes, elevated hematocrit, elevated neutrophils, and elevated hemoglobin.

The adverse effects of Calcitriol Airflow® are, in general, similar to those encountered with excessive vitamin D intake. The early and late signs and symptoms associated with vitamin D intoxication and hypercalcemia are:


Asthenia, headache, somnolence, nausea, cardiac arrhythmias, excessive thirst, vomiting, dry mouth, constipation, myalgia, bone pain, dysgeusia, decreased appetite, abdominal pain, and dyspepsia.


Polyuria, polydipsia, decreased appetite, weight decreased, nocturia, conjunctival deposit, pancreatitis, photophobia, rhinorrhoea, pruritus, hyperthermia, libido decreased, blood urea increased, albuminuria, hypercholesterolemia, aspartate aminotransferase increased, alanine aminotransferase increased, calcinosis, hypertension, cardiac arrhythmias, muscular weakness, paresthesia, dehydration, apathy, urinary tract infections, and rarely, overt psychosis.

Clinical Trial Adverse Drug Reactions

Because clinical trials are conducted under very specific conditions the adverse reaction rates observed in the clinical trials may not reflect the rates observed in practice and should not be compared to the rates in the clinical trials of another drug. Adverse drug reaction information from clinical trials is useful for identifying drug-related adverse events and for approximating rates.

Calcitriol Airflow® was studied in 20 patients undergoing maintenance hemodialysis for chronic renal disease. This open-label study had no comparator; each patient served as his/her own control. Patients received Calcitriol Airflow® three times weekly, post-dialysis over a treatment period of 4 to 8 weeks. Doses were titrated for each patient based upon serum total calcium response.

Abnormal Hematologic And Clinical Chemistry Findings

The most frequently reported adverse effect is hypercalcemia (35% approximately after the 4th week of treatment).

Post-Market Adverse Drug Reactions

Hypersensitivity reactions have been commonly reported in Post-Market Clinical Trials at a frequency of 2.3%. Rare postmarketing reports of anaphylaxis have also been received. Occasional mild pain and localized redness at the injection site have been observed. The adverse drug reactions occurring in patients receiving Calcitriol Airflow® in seven Post Market Clinical Studies are summarized for a total of 485 subjects randomized to Calcitriol Airflow® (Table 1).

Table 1: Summary of ADRs Occurring in Patients Receiving Calcitriol Airflow in Calcitriol Airflow® Post Market Clinical Trials

System Organ Class Very Common Common Uncommon Not Known
Infections and Infestations Urinary tract infection
Immune System Disorders Hypersensitivity*
Metabolism and Nutrition Disorders Decreased appetite Dehydration Polydipsia Hypercholesterolemia
Psychiatric Disorders Libido decreased Apathy Psychosis
Nervous System Disorders Headache Somnolence Paresthesia Dysgeusia
Eye Disorders Conjuctival deposit Photophobia
Cardiac Disorders Cardiac arrhythmia
Vascular Disorders Hypertension
Respiratory, Thoracic and Mediastinal Disorders Rhinorrhoea
Gastrointestinal Disorders Nausea Vomiting Constipation Abdominal pain Dyspepsia Pancreatitis Dry mouth
Skin and Subcutaneous Tissue Disorders Pruritus
Musculoskeletal and Connective Tissue Disorders Myalgia Bone pain Muscular weakness
Renal and Urinary Disorders Polyuria Nocturia Albuminuria
General Disorders and Administration Site Conditions Pain Injection site pain Asthenia Injection site reaction Calcinosis Hyperthermia
Investigations Weight decreased Aspartate aminotransferase increased Blood urea increased Alanine aminotransferase increased
*Anaphylaxis has not been observed in clinical trials.

What is the most important information I should know about Calcitriol Airflow?

  • Calcitriol Airflow solution may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Calcitriol Airflow solution. Using Calcitriol Airflow solution alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Carefully follow the diet plan provided by your doctor.
  • Check with your doctor before taking any vitamins or mineral supplements containing vitamin D or calcium, phosphorus, or antacids containing calcium or magnesium.
  • You will need to take care to not become dehydrated while you take Calcitriol Airflow solution. If you have normal kidney function, be sure to drink plenty of fluids. If you have kidney problems or are on dialysis, talk with your doctor about how much fluid you should drink each day. Discuss any questions with your doctor.
  • Tell your doctor you take Calcitriol Airflow solution if you will be having surgery or will be confined to a bed or chair for a long period of time. The risk of high blood calcium levels may be increased.
  • Lab tests, including calcium, phosphorus, magnesium, and alkaline phosphate levels, may be performed while you use Calcitriol Airflow solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Calcitriol Airflow solution should be used with extreme caution in CHILDREN younger than 13 year old and in CHILDREN who are on dialysis; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Calcitriol Airflow solution while you are pregnant. It is not known if Calcitriol Airflow solution is found in breast milk. Do not breast-feed while taking Calcitriol Airflow solution.

Calcitriol Airflow contraindications

infoContraindication can be described as a special circumstance or a disease or a condition wherein you are not supposed to use the drug or undergo particular treatment as it can harm the patient; at times, it can be dangerous and life threatening as well. When a procedure should not be combined with other procedure or when a medicine cannot be taken with another medicine, it is called Relative contraindication. Contraindications should be taken seriously as they are based on the relative clinical experience of health care providers or from proven research findings.

You should not use this medication if you have a severe form of psoriasis (with pus, skin peeling, severe redness).

Before using Calcitriol Airflow topical, tell your doctor if you have low or high levels of calcium in your blood, a calcium disorder or metabolic imbalance, or if you are receiving UV light treatments (phototherapy) for your psoriasis.

Tell your doctor about all other medicines you are using to treat psoriasis. Also tell your doctor if you are taking a diuretic (water pill) or vitamin or mineral supplements that contain calcium or vitamin D.

Calcitriol Airflow topical is for use only on areas of psoriasis. Avoid getting it on healthy skin areas. Calcitriol Airflow topical should not be applied to the face or the vaginal area.

Stop using this medication and call your doctor if you have a serious side effect such as blistering or severe redness, itching, or other irritation of treated skin.

Using Calcitriol Airflow topical can affect your body's ability to metabolize calcium. This can result in high levels of calcium in your blood (hypercalcemia). Symptoms of this condition include nausea, loss of appetite, constipation, increased thirst and urination, muscle weakness, confusion, and feeling tired or restless. Call your doctor if you have any of these symptoms.



  1. DailyMed. "CALCITRIOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. DTP/NCI. "calcitriol: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". (accessed September 17, 2018).
  3. European Chemicals Agency - ECHA. "Calcitriol: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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