Consists of Camphor Monobromide, Mallow, Methylthioninium Chloride
Mallow indications
Upper respiratory-tract inflammation The great demulcent and emollient properties of Marsh Mallow make it useful in inflammation and irritation of the alimentary canal, and of the urinary and respiratory organs.
Methylthioninium Chloride indications
Methenamine is indicated for prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug should only be used after eradication of the infection by other appropriate antimicrobial agents.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Methenamine and other antibacterial drugs, Methenamine should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Methylthioninium Chloride dosage
Oral
Maintenance therapy in chronic methaemoglobinaemia
Adult: 100-300 mg daily.
Oral
Urinary tract infections; Prophylaxis of urinary oxalate stones formation
Adult: 65-130 mg tid. Max dose: 390 mg/day.
Intravenous
Acute methaemoglobinaemia
Adult: As a 1% solution in doses of 1-2 mg/kg or 25-50 mg/m2 inj over several min. Repeat dose after 1 hr if required. Doses up to 300 mg daily have been used.
Child: As a 1% solution in doses of 1-2 mg/kg or 25-50 mg/m2 inj over several min. Repeat dose after 1 hr if required. Doses up to 300 mg daily have been used.
Methylthioninium Chloride side effects
Imparts a blue colour to saliva, urine, faeces and skin. IV (high doses): Nausea, vomiting, abdominal and chest pain, headache, dizziness, mental confusion, profuse sweating, dyspnoea, hypertension, methaemoglobinaemia, haemolysis.
Oral: GI disturbances, dysuria, fever (high doses), bladder irritation. Intra-amniotic: Haemolytic anaemia and hyperbilirubinaemia in newborn infants.
Methylthioninium Chloride contraindications
Methenamine is contraindicated in patients with renal insufficiency, severe hepatic insufficiency, or severe dehydration. Methenamine preparations should not be given to patients taking sulfonamides because some sulfonamides may form an insoluble precipitate with formaldehyde in the urine.
Active ingredient matches for Camphor Monobromide/Mallow/Methylthioninium Chloride:
Camphor Monobromide/Mallow/Methylthioninium Chloride
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Information checked by Dr. Sachin Kumar, MD Pharmacology
