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Carbachol Actions |
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Description: Carbachol has muscarinic and nicotinic activity. It is not inactivated by cholinesterases, so its actions are more prolonged than those of acetylcholine.
Onset: Miosis: 10-20 min.
Duration: Reduction in intraocular pressure: 8 hrs.
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Wash your hands before using eye medication.
To apply the eye drops:
Do not allow the tip of the dropper to touch any surface, including your eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.
Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medication.
Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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