What is Chlordiazepoxidum?
Chlordiazepoxidum is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Chlordiazepoxidum affects chemicals in the brain that may become unbalanced and cause anxiety.
Chlordiazepoxidum is used to treat anxiety disorders or alcohol withdrawal.
Chlordiazepoxidum may also be used for other purposes not listed in this medication guide.
Chlordiazepoxidum indications
Chlordiazepoxidum Hydrochloride Capsule is indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
The effectiveness of Chlordiazepoxidum Hydrochloride Capsule in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
How should I use Chlordiazepoxidum?
Use Chlordiazepoxidum injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Chlordiazepoxidum injection is usually administered as an injection at your doctor's office, hospital, or clinic.
- If you are using Chlordiazepoxidum injection at home, carefully follow the injection procedures taught to you by your health care provider.
- If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
- Try to stay in bed for 3 hours after taking Chlordiazepoxidum injection.
- Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
- If you miss a dose of Chlordiazepoxidum injection and you are using it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Chlordiazepoxidum injection.
Uses of Chlordiazepoxidum in details
Chlordiazepoxidum is used to treat anxiety and acute alcohol withdrawal. It is also used to relieve fear and anxiety before surgery. This medication belongs to a class of drugs called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA).
How to use Chlordiazepoxidum
Take this medication by mouth as directed by your doctor. The dosage is based on your age, medical condition, and response to treatment.
Use this medication exactly as prescribed. Do not increase your dose, take it more frequently or use it for a longer period of time than prescribed because this drug can be habit-forming. Also, if used for an extended period of time, do not suddenly stop using this drug without your doctor's approval. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased to avoid side effects such as seizures.
When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.
Chlordiazepoxidum description
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Chlordiazepoxidum has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Chlordiazepoxidum is a controlled substance in the U.S.
Chlordiazepoxidum dosage
Chlordiazepoxidum Dosage
Applies to the following strength(s): 5 mg; 10 mg; 25 mg; 100 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Anxiety
- Light Sedation
- Alcohol Withdrawal
Usual Geriatric Dose for:
- Anxiety
Usual Pediatric Dose for:
- Anxiety
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Precautions
- Dialysis
- Other Comments
Usual Adult Dose for Anxiety
Mild to moderate anxiety: 5 or 10 mg orally, 3 or 4 times per day
Severe anxiety: 20 or 25 mg orally, 3 or 4 times per day
Use: Relief of mild, moderate, and severe anxiety disorders
Usual Adult Dose for Light Sedation
On days preceding surgery, 5 to 10 mg orally, 3 or 4 times per day
Use: Relief of preoperative apprehension and anxiety
Usual Adult Dose for Alcohol Withdrawal
50 to 100 mg orally, followed by repeated doses as needed until agitation is controlled
Maximum dose: 300 mg orally per day
Use: Relief of withdrawal symptoms of acute alcoholism
Usual Geriatric Dose for Anxiety
Elderly or debilitated patients:
5 mg orally, 2 to 4 times per day
Use: Relief of mild, moderate, and severe anxiety disorders
Usual Pediatric Dose for Anxiety
6 years or older:
5 mg orally, 2 to 4 times per day; this may be increased to 10 mg orally, 2 to 3 times per day
Use: Relief of mild, moderate, and severe anxiety disorders
Renal Dose Adjustments
Renal impairment: Use with caution
Liver Dose Adjustments
Hepatic impairment: Use with caution
Precautions
Safety and efficacy have not been established in patients younger than 6 years.
Consult WARNINGS section for additional precautions.
US Controlled Substance: Schedule IV
Dialysis
Data not available
Other Comments
Storage requirements:
-Protect from light
Monitoring:
-Psychiatric: Patients with a history of alcohol or drug abuse, or patients with a marked personality disorder should be monitored frequently.
Patient advice:
-Patients should be cautioned against performing activities requiring complete mental alertness, such as operating machinery or driving a motor vehicle.
More about Chlordiazepoxidum
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Espanol
- 110 Reviews - Add your own review/rating
Consumer resources
- Chlordiazepoxidum
- Chlordiazepoxidum injection
- Chlordiazepoxidum hydrochloride (Advanced Reading)
- Other brands: Librium
Professional resources
- Chlordiazepoxidum (AHFS Monograph)
- More (4) »
Related treatment guides
- Alcohol Withdrawal
- Opiate Withdrawal
- Anxiety
- Burning Mouth Syndrome
- Light Sedation
- More (2) »
Chlordiazepoxidum interactions
See also:
What other drugs will affect Chlordiazepoxidum?
When this drug applied simultaneously with:
- antipsychotic drugs (neuroleptics), antidepressants, sedatives, hypnotics, anesthetics, analgesics, ethanol enhanced the inhibitory effect on central nervous system, especially when administered parenterally.
- concomitant use of antacids can delay but not reduce the absorption of Chlordiazepoxidum.
- hormonal contraceptives increases the effectiveness of Chlordiazepoxidum.
- with muscle relaxants may enhance the action of muscle relaxants, with levodopa - may suppress antiparkinsonian action.
- theophylline at low doses perverts sedative effect of Chlordiazepoxidum.
- phenobarbital and phenytoin may accelerate the metabolism of Chlordiazepoxidum. In rare cases this medication inhibits the metabolism and enhances the action of phenytoin.
- may increase the toxicity of cyclophosphamide.
- cimetidine, omeprazole, disulfiram may increase the intensity and duration of action of this medicine.
Chlordiazepoxidum side effects
See also:
What are the possible side effects of Chlordiazepoxidum?
Applies to Chlordiazepoxidum: oral capsule, oral tablet
As well as its needed effects, Chlordiazepoxidum (the active ingredient contained in Chlordiazepoxidum) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking Chlordiazepoxidum, check with your doctor immediately:
Rare
- Fainting
- mood or mental changes
- shakiness and unsteady walk
- unsteadiness, trembling, or other problems with muscle control or coordination
- Abdominal and muscle cramps
- chills
- clay-colored stools
- convulsions
- cough or hoarseness
- dark urine
- difficulty in speaking
- dizziness
- drooling
- fever with or without chills
- general feeling of tiredness or weakness
- headache
- itching
- light-colored stools
- loss of appetite
- loss of balance control
- lower back or side pain
- muscle trembling, jerking, or stiffness
- nausea and vomiting
- painful or difficult urination
- pale skin
- rash
- restlessness
- shakiness in the legs, arms, hands, or feet
- shuffling walk
- sleeplessness
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stiffness of the limbs
- stomach pain
- sweating
- swelling
- trouble sleeping
- twisting movements of the body
- unable to sleep
- uncontrolled movements, especially of the face, neck, and back
- unpleasant breath odor
- unusual bruising or bleeding
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
If any of the following symptoms of overdose occur while taking Chlordiazepoxidum, get emergency help immediately:
Symptoms of overdose:
- Change in consciousness
- lack of coordination
- loss of consciousness
- sleepiness or unusual drowsiness
Minor Side Effects
Some Chlordiazepoxidum side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
Incidence not known:
- Decreased interest in sexual intercourse
- difficulty having a bowel movement (stool)
- inability to have or keep an erection
- increased in sexual ability, desire, drive, or performance
- increased interest in sexual intercourse
- loss in sexual ability, desire, drive, or performance
- menstrual changes
- skin blisters
Chlordiazepoxidum contraindications
See also:
What is the most important information I should know about Chlordiazepoxidum?
this medicine is contraindicated in the presence of glaucoma (since the anticholinergic component may produce some degree of mydriasis) and in patients with prostatic hypertrophy and benign bladder neck obstruction. It is contraindicated in patients with known hypersensitivity to Chlordiazepoxidum hydrochloride and/or clidinium bromide.
Active ingredient matches for Chlordiazepoxidum:
List of Chlordiazepoxidum substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Chlordiazepoxide-Yimin Pharm (China) | |
| Chlordiazepoxyde | |
| Capsule; Oral; Chlordiazepoxide Hydrochloride 10 mg | |
| Capsule; Oral; Chlordiazepoxide Hydrochloride 25 mg | |
| Capsules; Oral; Chlordiazepoxide Hydrochloride 10 mg | |
| Capsules; Oral; Chlordiazepoxide Hydrochloride 25 mg | |
| Chlordixide (Thailand) | |
| Chlordixide 5 mg x 1's | |
| Chlordixide 10 mg x 1's | |
| Chloridazepoxide | |
| Chloridiazepide | |
| Chloridiazepoxide (Pakistan) | |
| Chlorodiazepoxide | |
| Chlorzep (Thailand) | |
| Chlozep | |
| Chlozep 10+1 Tablet (Synokem Pharmaceuticals Ltd) | $ 0.03 |
| CHLOZEP 1MG/10MG TABLET 1 strip / 10 tablets each (Synokem Pharmaceuticals Ltd) | $ 0.39 |
| Chlozep 1 mg/10 mg Tablet (Synokem Pharmaceuticals Ltd) | $ 0.04 |
| Chlozepid | |
| CLIDOX (India) | |
| CLIDOX Capsule/ Tablet / 5mg - 2.5mg / 100 units (Moraceae Pharmaceuticals (P) Ltd.) | $ 1.81 |
| Clidox Clidinium Br. 2.5mg, Chlordiazepoxide 5mg TAB / 100 (Moraceae Pharmaceuticals (P) Ltd.) | $ 2.10 |
| 100's (Moraceae Pharmaceuticals (P) Ltd.) | $ 4.22 |
| Clidox Clidinium bromide 2.5 mg, Chlordiazepoxide 5 mg, Dicyclomine hydrochloride 10mg. TAB / 100 (Moraceae Pharmaceuticals (P) Ltd.) | $ 4.22 |
| Clidox 10+5+2.5 Tablet (Moraceae Pharmaceuticals (P) Ltd.) | $ 0.04 |
| CLIDOX 2.5 MG/5 MG/10 MG TABLET 1 strip / 10 tablets each (Moraceae Pharmaceuticals (P) Ltd.) | $ 0.40 |
| CLIDOX coated tab 10's (Moraceae Pharmaceuticals (P) Ltd.) | $ 0.42 |
| Clidox Clidinium bromide 2.5 mg, Chlordiazepoxide 5 mg, Dicyclomine hydrochloride 10mg. TAB / 100 (Moraceae Pharmaceuticals (P) Ltd.) | $ 4.22 |
| Clidox 2.5 mg/5 mg/10 mg Tablet (Moraceae Pharmaceuticals (P) Ltd.) | $ 0.04 |
| Cligmax P | |
| Cligmax P 5+2.5 Tablet (Excare Laboratories) | $ 0.01 |
| Clirax | |
| Clirax 5+2.5 Tablet (Elite Pharma Pvt Ltd) | $ 0.02 |
| Clizep (Taiwan) | |
| Clizep 5 mg | |
| Cloact FC | |
| Cloact FC 10+1 Tablet (Newgen (Cadila Pharmaceuticals Ltd.)) | $ 0.03 |
| Clopoxide | |
| Clordiazepoxido Andromaco (Chile) | |
| Clordiazepoxido HCl Pharma Arte (Paraguay) | |
| Clordiazepoxido L.CH. (Chile) | |
| Comoben (Thailand) | |
| Comoben 10 mg x 1's | |
| Comoben 5 mg x 1's | |
| Consun (Japan) | |
| Contol (Japan) | |
| Contol 1% (Japan) | |
| Contol 10% (Japan) | |
| COREL (THRIFT) | |
| COREL TABLET 1 strip / 10 tablets each (Thrift Pharmaceuticals) | $ 0.24 |
| Cotrip Forte | |
| Cotrip Forte 10+25 Tablet (Consern Pharma Pvt Ltd.) | $ 0.02 |
| COTRIP FORTE 25 MG/10 MG TABLET 1 strip / 10 tablets each (Consern Pharma Pvt Ltd.) | $ 0.19 |
See 526 substitutes for Chlordiazepoxidum | |
References
- DailyMed. "AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "chlordiazepoxide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "chlordiazepoxide". http://www.drugbank.ca/drugs/DB00475 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Chlordiazepoxidum are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Chlordiazepoxidum. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
