Chlormet-DM Pregnancy

• Pregnancy of Chlormet-DM in details
• Chlormet-DM breastfeeding
• Chlormet-DM reviews

Pregnancy of Chlormet-DM in details

Chlormet-DM has been assigned pregnancy category C by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancies.

Oral Chlormet-DM crosses the placenta. While there are no literature reports linking the use of Chlormet-DM in pregnancy to birth defects, use late in pregnancy has been associated with adverse effects in the neonate (i.e. gray baby syndrome). Chlormet-DM should only be given during pregnancy when benefit outweighs risk. Use near term is considered contraindicated by some experts.

See references

Chlormet-DM breastfeeding

Chlormet-DM is excreted into human milk. Adverse effects have been noted in nursing infants, including refusal of the breast, intestinal gas, and heavy vomiting. In addition, there is a theoretic risk of idiosyncratic bone marrow suppression and Gray Syndrome in the infant. For this reason, use of Chlormet-DM during lactation is considered to be of concern by the American Academy of Pediatrics and contraindicated by others. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
2. "Product Information. Chloromycetin (Chlormet-DM)." Parke-Davis, Morris Plains, NJ.

References for breastfeeding information

1. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
2. Havelka J, Hejzlar M, Popov V, et al "Excretion of Chlormet-DM in human milk." Chemotherapy 13 (1968): 204-11
3. "Product Information. Chloromycetin (Chlormet-DM)." Parke-Davis, Morris Plains, NJ.
4. Matsuda S "Transfer of antibiotics into maternal milk." Biol Res Pregnancy Perinatol 5 (1984): 57-60
5. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

References

1. DailyMed. "DEXAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. DailyMed. "CHLORAMPHENICOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
3. PubMed Health. "Dexamethasone (By injection): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology