Chlorpheniramine Maleate Uses
Infectious-inflammatory diseases caused by microorganisms susceptible to ciprofloxacin, including respiratory diseases, diseases of abdominal and pelvic organs, bones, joints, skin, septicemia; severe infections of ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.
For Chlorpheniramine Maleate Citadel Fine Pharmaceuticals local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meybomity. Infectious lesions in the eyes from injury or contact with foreign bodies. Preoperative prophylaxis in ophthalmic surgery.
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
Individual. For oral administration dose of Chlorpheniramine Maleate Citadel Fine Pharmaceuticals is 250-750 mg 2 times / day. Treatment duration is from 7-10 days to 4 weeks.
For IV administration a single dose is 200-400 mg, the multiplicity of the introduction is 2 times / day, duration of treatment - 1-2 weeks and more if necessary. May be IV injected as jet but more preferably a drip for 30 minutes.
When Chlorpheniramine Maleate Citadel Fine Pharmaceuticals applied topically instilled 1-2 drops into the lower conjunctival sac of the affected eye every 1-4 hours. After improving the intervals between instillation can be increased. The maximum oral daily dose for adults is 1.5 g.
Activity increases when combined with beta-lactam antibiotics, aminoglycosides, vancomycin, clindamycin, metronidazole. Sukralfat, bismuth preparations, antacids containing aluminum ions, magnesium or calcium, cimetidine, ranitidine, vitamin and mineral supplement, iron sulfate, zinc, didanosine (recommended for 2 hours before or 4 hours after these drugs) reduce the suction. Probenecid, azlocillin increase the concentration in the blood. Decreases clearance and increases in plasma caffeine, aminophylline and theophylline (increased likelihood of side effects). Chlorpheniramine Maleate Citadel Fine Pharmaceuticals enhances the effect of warfarin and other oral anticoagulants (prolongs bleeding time). Increases nephrotoxicity of cyclosporine, increase the risk of CNS excitability and convulsive reactions against the background of NSAIDs. Medicines alkalinizing the urine (citrates, sodium bicarbonate, carbonic anhydrase inhibitors) reduce the solubility (increases the probability of crystalluria). Infusion solutions of ciprofloxacin ready to use can be combined with infusion solutions: 0.9% sodium chloride solution, Ringer's solution, Ringer lactate, 5 and 10% dextrose, 10% solution of fructose, and a solution containing 5% dextrose with 0,225 or 0.45% sodium chloride. Incompatible with solutions having a pH > 7.
Drowsiness, dizziness, headache, constipation, stomach upset, blurred vision, decreased coordination, or dry mouth/nose/throat may occur. These effects may decrease as your body adjusts to the medication. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.
To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Chlorpheniramine can dry up and thicken mucus in your lungs, making it more difficult to breathe and clear your lungs. To help prevent this effect, drink plenty of fluids unless otherwise directed by your doctor.
If you are using a sustained-release product, an empty tablet shell may appear in your stool. This is harmless.
If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (e.g., hallucinations, irritability, nervousness, confusion), ringing in the ears, trouble urinating.
Tell your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, fast/irregular heartbeat, seizure.
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Injection: Chlorpheniramine Maleate is contraindicated in comatose states, in patients who have received large amounts of central-nervous-system depressants (alcohol, sedative hypnotics, including barbiturates, general anesthetics, narcotics, narcotic analgesics, tranquilizers, etc.), and in patients who have demonstrated an idiosyncrasy or hypersensitivity to promethazine.
Under no circumstances should promethazine be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene
Chlorpheniramine Maleate HCl injection should not be given by the subcutaneous route; evidence of chemical irritation has been noted, and necrotic lesions have resulted on rare occasions following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection.
Syrup, Tablets and Suppositories: Phenergan Tablets and Suppositories are contraindicated for use in pediatric patients less than two years of age.
Phenergan Tablets and Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.
Chlorphenamine in Oman, Taiwan, United States.
Dexchlorpheniramine in United States.
|Unit description / dosage (Manufacturer)||Price, USD|
|Chlorpheniramine Maleate / VPP 4 mg x 1000's|
|Chlorpheniramine Maleate / Washington 4 mg x 1000's|
|Chlorpheniramine Maleate / Johnson 4 mg x 1000's|
|Chlorpheniramine Maleate / Johnson 8 mg x 1000's|
|Chlorpheniramine Maleate / S.T. 5 mg/1 mL x 1 mL|
|Chlorpheniramine Maleate / K.S. 4 mg x 1000's|
|Chlorpheniramine Maleate / Honten 4 mg x 1000's|
|Chlorpheniramine Maleate / Jen Sheng 4 mg x 1000's|
|Chlorpheniramine Maleate / Unifarma 4 mg|
|Chlorpheniramine Maleate / Prince 4 mg x 1000's|
|Chlorpheniramine Maleate / Sinton 5 mg/1 mL x 1 mL|
|Chlorpheniramine Maleate 10 mg Injection||$ 0.06|
|Chlorpheniramine Maleate 4 mg Bini Tablet||$ 0.01|
|Chlorpheniramine Maleate 4 mg Low Cost Tablet||$ 0.07|
|Chlorpheniramine Maleate 4 mg Tablet||$ 0.01|
|Chlorpheniramine Maleate 300 mg Injection||$ 0.01|
|Chlorpheniramine Maleate tablet 4 mg/1 (Contract Pharmacy Services Pa (US))|
|Chlorpheniramine Maleate tablet, film coated, extended release 12 mg/1 (Kvk Tech, Inc. (US))|
List of Chlorpheniramine Maleate substitutes (brand and generic names):
|Chlorpheniramine-Hisun Pharm (China)|
|Chlorpheno 2 mg/5 mL x 60 mL (Milano)|
|Chlorpheno 2 mg/5 mL x 1 gal (Milano)|
|Chlorpheno 10 mg/1 mL x 1 mL x 50's (Milano)|
|Chlorpyrimine (Malaysia, Singapore, Thailand)|
|Chlorpyrimine 4 mg x 1000's (Atlantic Lab)|
|Chlorpyrimine 10 mg/1 mL x 10 mL x 1's (Atlantic Lab)|
|Chlorpyrimine 4 mg x 1, 000's (Atlantic Lab)|
|Chlorpyrimine 10 mg/1 mL x 1 mL x 50's (Atlantic Lab)|
|Chlorpyrimine tab 4 mg 1000's (Atlantic Lab)|
|Chorphen 4 mg x 1, 000's|
|Citobal NF (Peru)|
|Clomin (Bangladesh, Pakistan)|
|CLOMIN Capsule/ Tablet / 20mg - 500mg / 1000 units (Core Healthcare Ltd.)||$ 6.75|
|CLOMIN Capsule/ Tablet / 20mg - 500mg / 10 units (Core Healthcare Ltd.)||$ 0.14|
|CLOMIN Drops / 10mg per ml / 10ml units (Core Healthcare Ltd.)||$ 0.17|
|CLOMIN Injection / 20mg / 2ml units (Core Healthcare Ltd.)||$ 0.04|
|Clomin 20+500 Tablet (Core Healthcare Ltd.)||$ 0.01|
|CLOMIN 20MG/500MG DROPS 1 packet / 10 ML drop each (Core Healthcare Ltd.)||$ 0.47|
|CLOMIN 20MG/500MG TABLET 1 packet / 1000 tablets each (Core Healthcare Ltd.)||$ 9.92|
|CLOMIN DROPS 1 packet / 15 ML drop each (Core Healthcare Ltd.)||$ 0.34|
|Clomin 20 mg/500 mg Drop (Core Healthcare Ltd.)||$ 0.47|
|Clomin Drop (Core Healthcare Ltd.)||$ 0.34|
|Clopheniramin Domesco (Vietnam)|
|Clopheniramin DOMESCO 4 mg x 5 Blister x 20 Tablet|
|Clopheniramin DOMESCO 4 mg x 20 Blister x 10 Tablet|
|Clopheniramin DOMESCO 4 mg x 1 Bottle 200 Tablet|
|Clopheniramin DOMESCO 4 mg x 1 Bottle 500 Tablet|
|Clorfenamina Iqfarma (Peru)|
|Clorfenamina Labot (Peru)|
|Clorfenamina Maleato (Chile, Ecuador, Peru)|
|Clorfenamina Maleato 10mg/1ml Sanderson (Paraguay)|
|Clorfenamina Maleato Biosano (Chile)|
|Clorfenamina Maleato L.CH. (Chile)|
|Clorfenamina Maleato Mintlab (Chile)|
|Clorfenamina Maleato Rider (Chile)|
|Clorfenamina Maleato Sanderson (Chile)|
|Clorfenamina Sanitas (Chile)|
|Clorfeniramin Arena (Romania)|
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Information checked by Dr. Sachin Kumar, MD Pharmacology