Chlorpromazine HCl Uses

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What is Chlorpromazine HCl?

Chlorpromazine HCl is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Chlorpromazine HCl is used to treat psychotic disorders such as schizophrenia or manic-depression, and severe behavioral problems in children ages 1 through 12.

Chlorpromazine HCl is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

Chlorpromazine HCl may also be used for purposes not listed in this medication guide.

Chlorpromazine HCl indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Chlorpromazine HCl is a phenothiazine neuroleptic and is indicated in the following conditions:

1) Psychotic conditions (especially paranoid), including schizophrenia, mania and hypomania.

2) As an adjunct in the short-term management of anxiety psychomotor agitation excitement, violent or dangerously impulsive behaviour.

3) Nausea or vomiting associated with terminal illness, where other agents are ineffective or unavailable.

4) Intractable hiccup.

5) Childhood schizophrenia and autism.

How should I use Chlorpromazine HCl?

Use Chlorpromazine HCl as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Chlorpromazine HCl is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Chlorpromazine HCl at home, a health care provider will teach you how to use it. Be sure you understand how to use Chlorpromazine HCl. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Chlorpromazine HCl if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Chlorpromazine HCl may irritate skin. Avoid contact with skin or clothing. Wear rubber gloves while using Chlorpromazine HCl.
  • Do not suddenly stop taking Chlorpromazine HCl.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Chlorpromazine HCl and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpromazine HCl.

Uses of Chlorpromazine HCl in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Chlorpromazine HCl is used for the treatment of schizophrenia (a long-term mental disorder often characterized by abnormal social behaviour and failure to recognize what is real), and other psychosis (in which some or all symptoms of schizophrenia may be present), particularly paranoia (misbeliefs and feelings of harassment), mania [overactive behaviour and hypomania (elated moods and excitability)], anxiety, agitation and violent or dangerously impulsive behaviour. Chlorpromazine HCl is also used for prolonged periods of hiccups, nausea and vomiting (when other drugs have failed), to lower body temperature in childhood schizophrenia and autism (learning and communication difficulties).

Chlorpromazine HCl description

A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Chlorpromazine HCl has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Chlorpromazine HCl is a controlled substance in the U.S.

Chlorpromazine HCl dosage

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Adult Initially 25-50 mg tid, increased if necessary. Doses of 75 mg may be given as single dose at night.

Maintenance: 25-100 mg tid. Psychotic patient Up to ≥1 g. Nausea & vomiting 10-25 mg every 4-6 hr. Elderly & debilitated patient 1/3-1/2 the adult dose. Childn >5 yr (w/ psychiatric conditions) 1/3-1/2 the adult dose, 1-5 yr 500 mcg/kg every 4-6 hr. Max: 75 mg daily (for childn >5 yr) or 40 mg daily (for childn 1-5 yr).

Chlorpromazine HCl interactions

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What other drugs will affect Chlorpromazine HCl?

Alcohol, barbiturates and other sedatives may intensify the CNS depressant effects of Chlorpromazine HCl and respiratory depression may occur.

The hypotensive effect of most antihypertensive agents, especially alpha-adrenoceptor blocking agents, may be exaggerated by Chlorpromazine HCl.

Chlorpromazine HCl has mild anticholinergic activity which may be enhanced by other anticholinergic drugs.

Anticholinergic drugs may decrease the antipsychotic effect of Chlorpromazine HCl. Chlorpromazine HCl may oppose the action of some drugs, including amphetamine, levodopa, adrenaline, clonidine and guanethidine.

Some drugs interfere with the absorption of neuroleptic agents, e.g. antacids, lithium, anti-Parkinsonian agents. Although increases or decreases have been observed in the plasma concentrations of a number of drugs, including propranolol and phenobarbitone, these were not of clinical significance.

At high dosage, Chlorpromazine HCl reduces the response to hypoglycaemic agents, which may require an increase in dosage of the latter.

Clinically significant adverse drug interactions with alcohol, guanethidine and hypoglycaemic agents are documented. Adrenaline must not be used in cases of overdosage with Chlorpromazine HCl. Other interactions are of theoretical interest and are not of a serious nature. Concomitant administration of desferrioxamine and prochlorperazine has been reported to cause a transient metabolic encephalopathy with loss of consciousness for 48 to 72 hours. The possibility of a similar occurrence with Chlorpromazine HCl exists, because it shares many of the pharmacological activities of prochlorperazine.

Chlorpromazine HCl side effects

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What are the possible side effects of Chlorpromazine HCl?

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Minor side effects include nasal stuffiness, dry mouth, insomnia and agitation.

Cardiovascular: Hypotension, especially postural, is relatively common and elderly patients or subjects with volume depletion are particularly susceptible. Cardiac arrhythmias have been reported in patients receiving neuroleptic agents and may be dose-related. They include atrial arrhythmia, A-V block, ventricular tachycardia and fibrillation. Pre-existing cardiac disease, hypokalaemia, concurrent use of tricyclic antidepressants and old age may predispose to development of arrhythmia. E.C.G. changes may occur, including widened QT interval, ST depression, U waves and T wave changes.

Blood: Mild leucopenia may occur in up to 30% of patients on prolonged high dosage. Agranulocytosis may occur rarely and is not dose-related. Unexplained infections or pyrexia require immediate haematological investigations.

Respiratory: Clinical doses of the neuroleptics usually have little effect on respiration. However, respiratory depression may occur in susceptible patients.

Hepatic: A very small percentage of patients may develop jaundice, which is usually transient and which may be preceded by sudden pyrexia after one to three weeks of treatment. The jaundice is obstructive in type and is frequently accompanied by an eosinophilia, indicating the allergic nature of the event. Chlorpromazine HCl therapy should be withdrawn if jaundice occurs.

Extrapyramidal: Acute dystonic or dyskinetic reactions may occur. These are usually transitory, are commoner in children and young adults and are more likely to occur within the first four days of treatment or after dosage increases. Akathisia may occur, characteristically following large initial doses.

Neuroleptic - induced parkinsonism is commoner in adults and the elderly and usually takes weeks or months of treatment to develop. Tremor is a common sign but rigidity, akinesia or other features of parkinsonism may also occur.

If tardive dyskinesia occurs, it is usually although not always associated with prolonged or high dosage. It may occur after treatment has been discontinued. To reduce the likelihood of tardive dyskinesia, the dosage should be kept low whenever possible.

Skin and Eyes: Various skin rashes may occur during therapy with Chlorpromazine HCl. Photosensitivity eruptions may occur and patients receiving high dosage should be advised to avoid exposure to direct sunlight. Contact skin sensitisation is a rare but serious complication in persons who frequently handle Chlorpromazine HCl preparations and particular care should be taken to avoid contact of the drug with the skin.

Ocular changes and a metallic greyish-mauve discolouration of exposed skin have been reported in some patients, mainly females, who received Chlorpromazine HCl continuously for long periods of between four and eight years.

Endocrine: Hyperprolactinaemia has been reported and may result in galactorrhoea, gynaecomastia or amenorrhoea; impotence has been reported.

Neuroleptic malignant syndrome: The syndrome may occur with use of any neuroleptic agent. Symptoms include clouding of consciousness, rigidity and other extrapyramidal effects, and autonomic dysfunction, most importantly hyperpyrexia. Treatment involves the immediate cessation of neuroleptic therapy and symptomatic management as appropriate.

Cases of venous thromboembolism, including cases of pulmonary embolism and cases of deep vein thrombosis have been reported with antipsychotic drugs- Frequency unknown

Chlorpromazine HCl contraindications

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What is the most important information I should know about Chlorpromazine HCl?

Chlorpromazine HCl is contraindicated in patients with a known hypersensitivity to the drug. Chlorpromazine HCl is also contraindicated in comatose patients, including those under the influence of alcohol or other central nervous system depressants.

Active ingredient matches for Chlorpromazine HCl:

Chlorpromazine HCl


Unit description / dosage (Manufacturer)Price, USD
Chlorpromazine Hcl 50 mg Injection$ 0.04

List of Chlorpromazine HCl substitutes (brand and generic names):

Chlorpromazine HCl-Bodene 50 mg/2 mL x 10's
Clorpromazin 25 mg x 1 Bottle 500 Tablet
Clorpromazin 25 mg x 1 Bottle 1200 Tablet
Clorpromazin 100 mg x 1 Bottle 400 Tablet
Clorpromazin 100 mg x 1 Bottle 1000 Tablet
Hatomazin 12.5 mg/2 mL x 2 mL
Hatomazin 12.5 mg/2 mL x 5 mL
Largactil 100 liquid 100 mg (Sanofi Aventis Canada Inc (Canada))
Largo 25 mg x 1000's (Beacons)
Largo 100 mg x 1000's (Beacons)
Zycloran tab 100 mg 100's (China Yanzhou)
Zycloran tab 200 mg 100's (China Yanzhou)

References

  1. DailyMed. "CHLORPROMAZINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "chlorpromazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "chlorpromazine". http://www.drugbank.ca/drugs/DB00477 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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