Chlorpromazine Hydrochloride Uses

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What is Chlorpromazine Hydrochloride?

Chlorpromazine Hydrochloride is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Chlorpromazine Hydrochloride is used to treat psychotic disorders such as schizophrenia or manic-depression, and severe behavioral problems in children ages 1 through 12.

Chlorpromazine Hydrochloride is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

Chlorpromazine Hydrochloride may also be used for purposes not listed in this medication guide.

Chlorpromazine Hydrochloride indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Infectious-inflammatory diseases caused by microorganisms susceptible to ciprofloxacin, including respiratory diseases, diseases of abdominal and pelvic organs, bones, joints, skin, septicemia; severe infections of ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.

For Chlorpromazine Hydrochloride Basic Pharmaceutical Corporation local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meybomity. Infectious lesions in the eyes from injury or contact with foreign bodies. Preoperative prophylaxis in ophthalmic surgery.

How should I use Chlorpromazine Hydrochloride?

Use Chlorpromazine Hydrochloride as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Chlorpromazine Hydrochloride is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Chlorpromazine Hydrochloride at home, a health care provider will teach you how to use it. Be sure you understand how to use Chlorpromazine Hydrochloride. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Chlorpromazine Hydrochloride if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Chlorpromazine Hydrochloride may irritate skin. Avoid contact with skin or clothing. Wear rubber gloves while using Chlorpromazine Hydrochloride.
  • Do not suddenly stop taking Chlorpromazine Hydrochloride.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Chlorpromazine Hydrochloride and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpromazine Hydrochloride.

Uses of Chlorpromazine Hydrochloride in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Chlorpromazine Hydrochloride is used for the treatment of schizophrenia (a long-term mental disorder often characterized by abnormal social behaviour and failure to recognize what is real), and other psychosis (in which some or all symptoms of schizophrenia may be present), particularly paranoia (misbeliefs and feelings of harassment), mania [overactive behaviour and hypomania (elated moods and excitability)], anxiety, agitation and violent or dangerously impulsive behaviour. Chlorpromazine Hydrochloride is also used for prolonged periods of hiccups, nausea and vomiting (when other drugs have failed), to lower body temperature in childhood schizophrenia and autism (learning and communication difficulties).

Chlorpromazine Hydrochloride description

A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Chlorpromazine Hydrochloride has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Chlorpromazine Hydrochloride is a controlled substance in the U.S.

Chlorpromazine Hydrochloride dosage


Usual Adult Dose for Psychosis

IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.

Oral: Initial Dose: 10 to 25 mg orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.

Usual Maintenance Dose: 200 mg/day orally

Some patients require higher dosages (e.g., 800 mg daily is not uncommon in discharged mental patients). Increase dosage gradually until symptoms are controlled. Maximum improvement may not be seen for weeks or even months. Continue optimum dosage for 2 weeks, then gradually reduce dosage to the lowest effective maintenance level.

Usual Adult Dose for Mania

Oral: 10 mg orally 3 to 4 times a day or 25 mg orally 2 to 3 times a day.

More severe cases: 25 mg orally 3 times a day.

After 1 to 2 days, dose may be increased by 20 to 50 mg/day at semiweekly intervals.

Prompt control of severe symptoms: 25 mg IM one time.

If necessary, repeat in 1 hour. Subsequent doses should be oral, 25 to 50 mg three times a day.

IM: 25 mg injection one time. If necessary, may give additional 25 to 50 mg injection in 1 hour.

Increase subsequent doses gradually over several days up to 400 mg every 4 to 6 hours in exceptionally severe cases.

Usually patient becomes quiet and cooperative within 24 to 48 hours and oral doses may be substituted.

Oral: 500 mg/day is generally sufficient. Gradual increases to 2000 mg/day or more may be necessary.

There is usually little therapeutic gain to be achieved by exceeding 1000 mg/day for extended periods.

Less acutely disturbed

Oral: 25 mg three times a day.

May increase gradually until effective dose is reached, usually 400 mg/day.

Usual Adult Dose for Nausea/Vomiting

Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary.

IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.

Rectal: One 100 mg suppository every 6 to 8 hours as needed. In some patients, half this dose will do.

Nausea/Vomiting During Surgery:

IM: 12.5 mg one time. May repeat in 30 minutes if necessary and if no hypotension occurs.

IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1 mg/mL.

Usual Adult Dose for Light Sedation

For light sedation prior to a medical or surgical procedure:

Oral: 25 to 50 mg, 2 to 3 hours before the operation.

IM: 12.5 to 25 mg, 1 to 2 hours before operation.

Usual Adult Dose for Hiccups

Oral: 25 to 50 mg 3 to 4 times a day.

IM: If symptoms persist for 2 to 3 days, give 25 to 50 mg IM.

IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50 mg in 500 to 1000 mL of saline.

Usual Adult Dose for Porphyria

Oral: 25 to 50 mg 3 to 4 times a day.

Can usually be discontinued after several weeks, but maintenance therapy may be necessary for some patients.

IM: 25 mg injection 3 to 4 times a day until patient can take oral therapy.

Usual Adult Dose for Tetanus

IM: 25 to 50 mg given 3 to 4 times daily, usually in conjunction with barbiturates. Total doses and frequency of administration must be determined by the patient's response, starting with low doses and increasing gradually.

IV: 25 to 50 mg diluted to at least 1 mg/mL and administered at a rate of 1 mg/min.

Usual Pediatric Dose for Opiate Withdrawal

less than 1 month:

Neonatal abstinence syndrome (withdrawal from maternal opioid use; controls CNS and gastrointestinal symptoms):

Intramuscular: Initial: 0.55 mg/kg/dose given every 6 hours; change to oral after approximately 4 days, decrease dose gradually over 2 to 3 weeks. Note: Chlorpromazine Hydrochloride is rarely used for neonatal abstinence syndrome due to adverse effects such as hypothermia, cerebellar dysfunction, decreased seizure threshold, and eosinophilia; other agents are preferred.

Usual Pediatric Dose for Schizophrenia

6 months and older:

Oral: 0.5 to 1 mg/kg/dose orally every 4 to 6 hours; older children may require 200 mg/day or higher

intramuscular or intravenous: 0.5 to 1 mg/kg/dose every 6 to 8 hours

Maximum recommended doses:

less than 5 years (less than 22.7 kg): 40 mg/day

5 years and older: (22.7 to 45.5 kg): 75 mg/day

Usual Pediatric Dose for Nausea/Vomiting

Nausea and vomiting:

Oral: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed

intramuscular or intravenous: 0.5 to 1 mg/kg/dose every 6 to 8 hours;

Maximum recommended doses:

less than 5 years (less than 22.7 kg): 40 mg/day

5 and older (22.7-45.5 kg): 75 mg/day

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Adjust dosage to individual and the severity of condition, recognizing that the mg for mg potency relationship among all dosage forms has not been precisely established clinically. It is important to increase dosage until symptoms are controlled. Dosage should be increased more gradually in debilitated or emaciated patients. In continued therapy, gradually reduce dosage to the lowest effective maintenance level, after symptoms have been controlled for a reasonable period.

In general, dosage recommendations for other oral forms of the drug may be applied to the sustained release capsules on the basis of total daily dosage in milligrams.

The 100 mg and 200 mg tablets are for use in severe neuropsychiatric conditions.


In general, dosage levels should be lower in the elderly, the emaciated and the debilitated. Chlorpromazine Hydrochloride should be used cautiously in patients with cardiovascular, liver or renal disease.


Data not available

Other Comments

Chlorpromazine Hydrochloride should generally not be used in children under 6 months of age except where potentially lifesaving.

Chlorpromazine Hydrochloride interactions

See also:
What other drugs will affect Chlorpromazine Hydrochloride?


The CNS depressant actions of Chlorpromazine Hydrochloride and other neuroleptic agents may be intensified (additively) by alcohol, barbiturates and other sedatives. Respiratory depression may occur.

The hypotensive effect of most anithypertensive drugs especially α-adrenoreceptor blocking agents may be exaggerated by Chlorpromazine Hydrochloride.

The mild anticholinergic effect of Chlorpromazine Hydrochloride may be enhanced by other anticholinergic drugs possibly leading to constipation, heat stroke, etc.

The action of some drugs may be opposed by Chlorpromazine Hydrochloride: These include amphetamine, levodopa, clonidine, guanethidine, adrenaline.

Anticholinergic agents may reduce the antipsychotic effect of Chlorpromazine Hydrochloride.

Some drugs interfere with absorption of neuroleptic agents: Antacids, anti-parkinson, lithium. Increases or decreases in plasma concentration of a number of drugs eg, propranolol, phenobarbitone have been observed but were not of clinical significance.

High doses of Chlorpromazine Hydrochloride reduce the response to hypoglycemic agents, the dosage of which might have been raised.

Documented adverse clinically significant interactions occur with alcohol, guanethidine and hypoglycemic agents. Adrenaline must not be used in patients overdosed with Chlorpromazine Hydrochloride.

Simultaneous administration of desferrioxamine and prochlorperazine has been observed to induce a transient metabolic encephalopathy characterized by loss of consciousness for 48-72 hrs. It is possible that this may occur with Chlorpromazine Hydrochloride since it shares many of the pharmacological activities of prochlorperazine.

Chlorpromazine Hydrochloride side effects

See also:
What are the possible side effects of Chlorpromazine Hydrochloride?

Minor Adverse Reaction: Nasal stuffiness, dry mouth, insomnia, agitation.

Liver Function: Jaundice, usually transient, occurs in a very small percentage of patients taking Chlorpromazine Hydrochloride. A premonitory sign may be sudden onset of fever after 1-3 weeks of treatment followed by the development of jaundice. Chlorpromazine Hydrochloride jaundice has the biochemical and other characteristics of obstructive jaundice and is associated with obstructions of the canaliculi by bile thrombi; the frequent resence of an accompanying eosinophilia indicates the allergic nature of this phenomenon. Treatment should be withheld on the development of jaundice.

Cardio-Respiratory: Hypotension, usually postural, commonly occurs. Elderly or volume-depleted subjects are particularly susceptible; it is more likely to occur after IM administration.

Cardiac arrhythmias, including atrial arrhythmia, AV block, ventricular tachycardia and fibrillation have been reported during neurologic therapy, possibly related to dosage. Preexisting cardiac dosage, old age, hypokalemia and concurrent tricyclic antidepressants may predispose. ECG changes, usually benign, include widened QT interval, ST depression, U-waves and T-waves changes.

Respiratory depression is possible in susceptible patients.

Blood: A mild leucopenia occurs in up to 30% of patients on prolonged high dosage. Agranulocytosis may occur rarely; it is not dose-related. The occurrence of unexplained infections or fever requires immediate hematological investigation.

Extrapyramidal: Acute dystonias or dykinesias, usually transitory are more common in children and young adults and usually occur within the first 4 days of treatment or after dosage increases.

Akathisia characteristically occurs after large initial doses.

Parkinsonism is more common in adults and the elderly. It usually develops after weeks or months of treatment. One or more of the following may be seen: Tremor, rigidity, akinesia or other features of parkinsonism. Commonly, just tremor.

Tardive Dyskinesia: If this occurs, is it usually but not necessarily, after prolonged or high dosage. It can even occur after treatment has been stopped. Dosage should be kept low whenever possible.

Skin and Eyes: Contact skin sensitization is a serious but rare complication in those frequently handling preparations of Chlorpromazine Hydrochloride. The greatest care must be taken to avoid contact of Chlorpromazine Hydrochloride with the skin. Skin rashes of various kinds may also be seen in patients treated with Chlorpromazine Hydrochloride. Patients on high dosage should be warned that they may develop photosensitivity in sunny weather and should avoid exposure to direct sunlight.

Chlorpromazine Hydrochloride contraindications

See also:
What is the most important information I should know about Chlorpromazine Hydrochloride?

Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Chlorpromazine Hydrochloride is not for use in psychotic conditions related to dementia. Chlorpromazine Hydrochloride may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Do not use Chlorpromazine Hydrochloride if you have brain damage, bone marrow depression, or are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to Chlorpromazine Hydrochloride or other phenothiazines.

Before you take Chlorpromazine Hydrochloride, tell your doctor if you have liver or kidney disease, heart disease or high blood pressure, glaucoma, severe breathing problems, past or present breast cancer, low levels of calcium in your blood, adrenal gland tumor, enlarged prostate or urination problems, a history of seizures, Parkinson's disease, or if you have ever had a serious side effect while using Chlorpromazine Hydrochloride or similar medicines.

Before taking Chlorpromazine Hydrochloride, tell your doctor about all other medications you use.

Active ingredient matches for Chlorpromazine Hydrochloride:

Chlorpromazine Hydrochloride

Unit description / dosage (Manufacturer)Price, USD
1 milliliter in 1 ampule
2 milliliter in 1 ampule
Chlorpromazine Hydrochloride injection 25 mg/mL (West Ward Pharmaceutical Corp. (US))
Chlorpromazine Hydrochloride tablet, sugar coated 100 mg/1 (Cardinal Health (US))
Chlorpromazine Hydrochloride tablet, sugar coated 50 mg/1 (REMEDYREPACK INC. (US))
Chlorpromazine Hydrochloride tablet, sugar coated 25 mg/1 (Mylan Institutional Inc. (US))
Chlorpromazine Hydrochloride tablet, sugar coated 200 mg/1 (Clinical Solutions Wholesale (US))
Chlorpromazine Hydrochloride tablet, sugar coated 10 mg/1 (Upsher Smith Laboratories, Inc. (US))
Chlorpromazine Hydrochloride tablet, film coated 25 mg/1 (Physicians Total Care, Inc. (US))
Chlorpromazine Hydrochloride tablet 200 mg/1 (REMEDYREPACK INC. (US))
Chlorpromazine Hydrochloride tablet 50 mg/1 (REMEDYREPACK INC. (US))

List of Chlorpromazine Hydrochloride substitutes (brand and generic names):

25 mg x 10's (La Pharma)$ 0.04
50 mg x 10's (La Pharma)$ 0.06
100 mg x 10's (La Pharma)$ 0.10
200 mg x 10's (La Pharma)$ 0.15
Emetil 25mg TAB / 10 (La Pharma)$ 0.04
Emetil 50m TAB / 10 (La Pharma)$ 0.06
Emetil 100mg TAB / 10 (La Pharma)$ 0.10
Emetil 200mg TAB / 10 (La Pharma)$ 0.15
EMETIL 100 MG TABLET 1 strip / 10 tablets each (La Pharma)$ 0.12
EMETIL 25 MG TABLET 1 strip / 10 tablets each (La Pharma)$ 0.05
EMETIL 50 MG TABLET 1 strip / 10 tablets each (La Pharma)$ 0.07
EMETIL tab 25 mg x 10's (La Pharma)$ 0.04
EMETIL tab 50 mg x 10's (La Pharma)$ 0.07
EMETIL tab 100 mg x 10's (La Pharma)$ 0.11
EMETIL tab 200 mg x 10's (La Pharma)$ 0.15
Emetil 25mg TAB / 10 (La Pharma)$ 0.04
Emetil 50m TAB / 10 (La Pharma)$ 0.06
Emetil 100mg TAB / 10 (La Pharma)$ 0.10
Emetil 200mg TAB / 10 (La Pharma)$ 0.15
Emetil 100mg Tablet (La Pharma)$ 0.01
Emetil 25mg Tablet (La Pharma)$ 0.00
Emetil 50mg Tablet (La Pharma)$ 0.01


  1. DailyMed. "CHLORPROMAZINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "chlorpromazine". (accessed September 17, 2018).
  3. DrugBank. "chlorpromazine". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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