Consists of chondroitin sulphate, Glucosamine HCl, manganese, Mg, vit C, Zn
What happens if I overdose Chondroitin sulphate?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Chondroitin sulphate?
Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.
Chondroitin sulphate warnings
Pregnancy and breast-feeding: Not enough is known about the use of Chondroitin sulphate sulfate during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Asthma: There is some concern that Chondroitin sulphate sulfate might make asthma worse. If you have asthma, use Chondroitin sulphate sulfate cautiously.
Prostate cancer: Preliminary research suggests that Chondroitin sulphate may cause the spread or recurrence of prostatecancer. This effect has not been shown with Chondroitin sulphate sulfate supplements. Still, until more is known, don
What should I discuss with my healthcare provider before taking Chondroitin sulphate?
You should not use this product if you are allergic to Chondroitin sulphate.
Before using Chondroitin sulphate, talk to your healthcare provider. You may not be able to use Chondroitin sulphate if you have certain medical conditions.
It is not known whether Chondroitin sulphate will harm an unborn baby. Do not use this product without medical advice if you are pregnant.
Chondroitin sulphate may pass into breast milk and may harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.
Do not give any herbal/health supplement to a child without medical advice.
Chondroitin sulphate precautions
Pregnancy & lactation. Childn.
What happens if I miss a dose of Chondroitin sulphate?
Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra Chondroitin sulphate to make up the missed dose.
What happens if I overdose Glucosamine HCl?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately.
Proper storage of Glucosamine HCl:
Store at room temperature away from heat, moisture, and light unless otherwise directed on the package label. Do not store in the bathroom. Most dietary supplements are not in childproof containers. Keep Glucosamine HCl out of the reach of children and away from pets.
Overdose of Glucosamine HCl in details
No cases of accidental or intentional overdose are known. The acute animal and chronic toxicological studies of Glucosamine HCl active ingredients indicate that toxic effects and symptoms of toxicity are not likely to occur, even after high overdoses.
However, if overdose occur the treatment should be symptomatic eg, hydroelectrolytic balance restoration.
What should I avoid while taking Glucosamine HCl?
Some Glucosamine HCl products also contain manganese. Taking too much of this combination can cause a manganese overdose. Do not take more than directed on the medicine label.
Glucosamine HCl warnings
History of GI ulceration; impaired cardiac, renal or hepatic function; hypertension; lactation. IV admin in patients with moderate or severe renal impairment; hypovolaemia or dehydration; asthma, porphyria. Monitor LFTs in patients on prolonged therapy. May prolong bleeding time; caution when used in patients with coagulation disorders or on anticoagulants. Prolonged therapy may increase risk of anaemia. 1st and 2nd trimester of pregnancy. Elderly, debilitated patients.
pregnancy:
Category B(Parenteral): Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Category C(Ophth /
Topical): Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
What should I discuss with my healthcare provider before taking Glucosamine HCl?
You should not use this product if you are allergic to Glucosamine HCl.
Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have:
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diabetes;
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high cholesterol or triglycerides (a type of fat in the blood);
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cancer;
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liver disease;
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asthma or other breathing disorder;
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if you are allergic to shellfish; or
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if you take a blood thinner (warfarin, Coumadin, Jantoven).
It is not known whether Glucosamine HCl will harm an unborn baby. Do not use this product without medical advice if you are pregnant.
Glucosamine HCl may pass into breast milk and may harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.
Do not give any herbal/health supplement to a child without medical advice.
Glucosamine HCl precautions
Glucosamine HCl is not indicated for the treatment of acute painful symptoms.
Glucosamine HCl contains sodium and needs to be taken into consideration by patients on a controlled sodium diet.
In patients with cardiac and/or renal insufficiency, edema and water retention was observed very rarely.
This effect could be attributed to the effect of Glucosamine HCl sulphate. The administration of Glucosamine HCl to these patients should be under strict medical supervision.
No special studies were performed in patients with hepatic insufficiency. The administration of Glucosamine HCl to patients with severe hepatic insufficiency should be under strict medical supervision.
Caution is advised in treatment of patients with impaired glucose tolerance. Closer monitoring of blood sugar levels may be necessary at the beginning of treatment.
An increased effect of coumarinic anticoagulants (eg, warfarin) during concomitant consumption of Glucosamine HCl sulphate, one of the active ingredients of Glucosamine HCl, may occur. Therefore, a closer monitoring of the coagulation parameters may be considered in those patients being treated with Glucosamine HCl.
Due to its Glucosamine HCl sulphate content, in case of concomitant administration of platelet antiaggregant drugs eg, acetylsalicylic acid, dipyridamole, clopidogrel, ditazol, trifusal and ticlopidine, Glucosamine HCl should be administered under strict medical supervision.
Concurrent consumption of Glucosamine HCl sulphate may increase the gastrointestinal absorption of tetracyclines. Caution is advised in case of concomitant administration of Glucosamine HCl and tetracyclines.
The colouring agent sunset yellow (E110) may cause allergic reactions.
Effects on the Ability to Drive or Operate Machinery: No important effects on the central nervous system or motor system are known that might impair the ability to drive or use machines. However, caution is advised if somnolence or visual disturbances are experienced.
Use in pregnancy & lactation: In the absence of studies on reproductive function in humans, the use of Glucosamine HCl during pregnancy and lactation should be avoided.
What happens if I miss a dose of Glucosamine HCl?
Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra Glucosamine HCl to make up the missed dose.
Overdose of Manganese in details
Manganese toxicity in TPN patients has not been reported.
Manganese warnings
Direct intramuscular or intravenous injection of Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) is contraindicated as the acidic pH of the solution (pH 2.0) may cause considerable tissue irritation.
Liver and/or biliary tract dysfunction may require omission or reduction of copper and Manganese doses because these elements are primarily eliminated in the bile.
WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.
What should I discuss with my healthcare provider before taking Manganese?
- If you have an allergy to manganese or any other part of Manganese (manganese capsules and tablets).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Manganese precautions
General
Do not use unless solution is clear and seal is intact.
Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) should only be used in conjunction with a pharmacy directed admixture program using aseptic technique in a laminar flow environment; it should be used promptly and in a single operation without any repeated penetrations. Solution contains no preservatives; discard unused portion immediately after admixture procedure is completed.
Laboratory Tests
Serum Manganese levels can be measured periodically at the discretion of the investigator. Because of the low serum concentration normally present, samples will usually be analyzed by a reference laboratory.
Carcinogenesis, Mutagenesis, and Impairment of Fertility
Long-term animal studies to evaluate the carcinogenic potential of Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) have not been performed, nor have studies been done to assess mutagenesis or impairment of fertility.
Nursing Mothers
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) additive is administered to a nursing woman.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Pregnancy Category C.
Animal reproduction studies have not been conducted with Manganese chloride. It is also not known whether Manganese chloride can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Manganese chloride should be given to a pregnant woman only if clearly indicated.
Geriatric Use
An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Overdose of Vit C in details
Symptoms: long-term use of large doses (more than 1 g) - headache, increased CNS excitability, insomnia, nausea, vomiting, diarrhea, gastritis giperatsidnyh, ultseratsiya gastrointestinal mucosa, inhibition of the function insular apparatus of the pancreas (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate thamuria (when receiving a dose of 600 mg / day).
Decrease capillary permeability (possibly deteriorating trophic tissues, increased blood pressure, hypercoagulability, the development of microangiopathy).
When IV administration in high doses - the threat of termination of pregnancy (due to estrogenemia), hemolysis of red blood cells.
Vit C warnings
Vit C is used with caution in patients with hyperoxaluria, renal impairment, a history of instructions on urolithiasis. Because ascorbic acid increases iron absorption, its use in high doses can be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia.
Patients with high content body iron should apply ascorbic acid in minimal doses.
Vit C is used with caution in patients with deficiency of glucose-6-phosphate dehydrogenase.
The use of ascorbic acid in high doses can cause exacerbation of sickle cell anemia.
Data on the diabetogenic action of ascorbic acid are contradictory. However, prolonged use of ascorbic acid should periodically monitor your blood glucose levels.
It is believed that the use of ascorbic acid in patients with rapidly proliferating and widely disseminated tumors may worsen during the process. It should therefore be used with caution in ascorbic acid in patients with advanced cancer.
Absorption of ascorbic acid decreased while use of fresh fruit or vegetable juices, alkaline drinking.
Vit C precautions
Patients w/ hyperoxaluria. Tolerance may be induced in patients taking high doses.
Zn precautions
Copper deficiency.
References
- DrugBank. "Manganese". http://www.drugbank.ca/drugs/DB06757 (accessed September 17, 2018).
- MeSH. "Trace Elements". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- EPA Chemicals under the TSCA. "Manganese: The Chemical Data Reporting under the Toxic Substances Control Act (TSCA) contains chemical physical description and chemical use categories.". http://www.epa.gov/chemical-data-rep... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
