An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Intravenous
Susceptible infections
Adult: Combined with Cilapen: (as anhydrous Cilapen) 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 min, and doses of 750 mg or 1 g over 40-60 min. Max: 4 g/day or 50 mg/kg.
Child: >40 kg: same as adult dose. Child >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Doses up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr. Max: >40 kg: 4 g/day or 50 mg/kg; <40 kg: 2 g/day.
Renal impairment: Max doses based on CrCl.
CrCl (ml/min)
Dosage Recommendation
31-70
500 mg every 6-8 hr.
21-30
500 mg every 8-12 hr.
6-20
250 mg or 3.5 mg/kg (whichever is lower) every 12 hr.
≤5
Only give if haemodialysis is started within 48 hr.
Intravenous
Prophylaxis of surgical infections
Adult: 1 g may be given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.
Intramuscular
Mild to moderate susceptible infections
Adult: 500 or 750 mg every 12 hr.
Intramuscular
Uncomplicated gonorrhoea
Adult: 500 mg as a single dose.
Uses of Cilapen in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Cilapen in combination with Cilapen (inhibitor of enzyme dehydropeptidase) is used to treat bacterial infections of lung (pneumonia), urinary tract, abdomen, blood, skin and soft tissue. It is also used to treat infections during or after delivery. It may be used in the management of fever of patients with reduced immunity due to low white blood cells (neutropenia).
Cilapen description
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with Cilapen, a renal dipeptidase inhibitor. [PubChem]
Cilapen dosage
Intravenous
Susceptible infections
Adult: Combined with Cilapen: (as anhydrous Cilapen) 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 min, and doses of 750 mg or 1 g over 40-60 min. Max: 4 g/day or 50 mg/kg.
Child: >40 kg: same as adult dose. Child >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Doses up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr. Max: >40 kg: 4 g/day or 50 mg/kg; <40 kg: 2 g/day.
Renal impairment: Max doses based on CrCl.
CrCl (ml/min)
Dosage Recommendation
31-70
500 mg every 6-8 hr.
21-30
500 mg every 8-12 hr.
6-20
250 mg or 3.5 mg/kg (whichever is lower) every 12 hr.
≤5
Only give if haemodialysis is started within 48 hr.
Intravenous
Prophylaxis of surgical infections
Adult: 1 g may be given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.
Intramuscular
Mild to moderate susceptible infections
Adult: 500 or 750 mg every 12 hr.
Intramuscular
Uncomplicated gonorrhoea
Adult: 500 mg as a single dose.
Cilapen interactions
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Increased risk of seizures when used with ganciclovir. Ciclosporin may increase neurotoxicity of ifosfamide; ifosfamide may also raise serum levels of ciclosporin. Serum levels may be increased by uricosuric agents. May reduce efficacy of valproic acid; monitor.
Cilapen side effects
Skin rashes, urticaria, eosinophilia, fever, nausea, vomiting, diarrhoea, tooth or tongue discoloration, and altered taste. Erythema multiforme, exfoliative dermatitis. Pain and thrombophlebitis may occur at the inj site.
Potentially Fatal: Severe anaphylactic reactions. Stevens-Johnson syndrome and toxic epidermal necrolysis.
DailyMed. "CILASTATIN SODIUM; IMIPENEM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
DailyMed. "CILASTATIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Cilapen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cilapen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
3 consumers reported useful
Was the Cilapen drug useful in terms of decreasing the symptom or the disease? According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users
%
Useful
3
100.0%
Consumer reported price estimates
No survey data has been collected yet
3 consumers reported time for results
To what extent do I have to use Cilapen before I begin to see changes in my health conditions? As part of the reports released by ndrugs.com website users, it takes 3 days and a few days before you notice an improvement in your health conditions. Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Cilapen. To get the time effectiveness of using Cilapen drug by other patients, please click here.
Users
%
3 days
2
66.7%
1 week
1
33.3%
15 consumers reported age
Users
%
> 60
4
26.7%
16-29
3
20.0%
6-15
3
20.0%
46-60
3
20.0%
1-5
2
13.3%
Consumer reviews
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