Dosage of Ciprofloxacin 0.3% Thephaco in details
Ciprofloxacin 0.3% Thephaco XR and Ciprofloxacin 0.3% Thephaco immediate-release tablets are not interchangeable. Ciprofloxacin 0.3% Thephaco XR should be administered orally once daily (Table 1).
Patients whose therapy is started with Ciprofloxacin 0.3% Thephaco IV for UTIs may be switched to Ciprofloxacin 0.3% Thephaco XR when clinically indicated at the discretion of the physician.
- Ciprofloxacin 0.3% Thephaco XR tablets should be taken whole and not split, crushed, or chewed.
- Ciprofloxacin 0.3% Thephaco XR should be administered at least 2 hours before or 6 hours after antacids containing magnesium or aluminum, polymeric phosphate binders (for example, sevelamer, lanthanum carbonate), as well as sucralfate, VIDEX® (didanosine) chewable/buffered tablets or pediatric powder, other highly buffered drugs, metal cations such as iron, and multivitamin preparations with zinc.
- Concomitant administration of Ciprofloxacin 0.3% Thephaco XR with dairy products (like milk or yogurt) or with calcium-fortified products alone should be avoided since decreased absorption is possible. A 2-hour window between substantial calcium intake (greater than 800 mg) and dosing with Ciprofloxacin 0.3% Thephaco XR is recommended.
Adequate hydration of patients receiving Ciprofloxacin 0.3% Thephaco XR should be maintained to prevent the formation of highly concentrated urine. Crystalluria has been reported with quinolones.
Impaired Renal Function
- In patients with cUTI and acute uncomplicated pyelonephritis with a creatinine clearance of ≤ 30 mL/min, the dose of Ciprofloxacin 0.3% Thephaco XR should be reduced from 1000 mg to 500 mg daily. The use of Ciprofloxacin 0.3% Thephaco 1000 mg XR tablets is not recommended in this patient population.
- For patients on hemodialysis or peritoneal dialysis, administer Ciprofloxacin 0.3% Thephaco XR after the dialysis procedure is completed (maximum dose should be Ciprofloxacin 0.3% Thephaco 500 mg XR every 24 hours). The use of Ciprofloxacin 0.3% Thephaco 1000 mg XR is not recommended in this patient population.
- For patients on continuous ambulatory peritoneal dialysis (CAPD), the maximum dose should be 500 mg every 24 hours.
What other drugs will affect Ciprofloxacin 0.3% Thephaco?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Ciprofloxacin 0.3% Thephaco, especially:
cyclosporine, methotrexate, metoclopramide, omeprazole, pentoxifylline, phenytoin, probenecid, ropinirole, sildenafil, theophylline;
a diuretic or "water pill";
heart rhythm medication--amiodarone, disopyramide, dofetilide, dronedarone, procainamide, quinidine, sotalol, and others;
medicine to treat depression or mental illness--amitriptylline, clomipramine, clozapine, desipramine, duloxetine, iloperidone, imipramine, nortriptyline, and others; or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with Ciprofloxacin 0.3% Thephaco, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Ciprofloxacin 0.3% Thephaco interactions
Concomitant administration of Ciprofloxacin 0.3% Thephaco and iron, sucralfate, or
antacid containing magnesium, aluminum or calcium reduces the absorption
of Ciprofloxacin 0.3% Thephaco. Therefore, Ciprofloxacin 0.3% Thephaco should be taken 1
hr. before or 4 hrs. after taking these products.
Concomitant administration of Ciprofloxacin 0.3% Thephaco and theophylline can cause
an undesirable rise in the serum theophylline concentration which may
lead to theophylline-determined side effects.
Animal studies show that the combination of very high doses of quinolones
(gyrase inhibitors) and certain anti-inflammatory drugs (nonsteroidal
anti-inflammatories) can provoke convulsions. This is not, however,
the case with drugs containing acetylsalicylic acid.
Concomitant administration of Ciprofloxacin 0.3% Thephaco and warfarin can intensify
the action of the warfarin.
After concomitant administration of Ciprofloxacin 0.3% Thephaco and glibenclamide, the
action of the glibenclamide can be intensified in isolated cases lowering
of blood glucose (hypoglycaemia).
Probenecid influences the excretion of Ciprofloxacin 0.3% Thephaco in the urine. After
concomitant administration of Ciprofloxacin 0.3% Thephaco and probenecid, the concentration
of Ciprofloxacin 0.3% Thephaco in the blood (serum) rises.
Metoclopramide reduces the uptake of Ciprofloxacin 0.3% Thephaco into circulation,
leading to maximum concentrations in the blood (serum) within a short
- DailyMed. "CIPROFLOXACIN; DEXAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "5E8K9I0O4U: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- Wikipedia. "ciprofloxacin: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Ciprof... (accessed September 17, 2018).
- MeSH. "Topoisomerase II Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl): The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
ReviewsThe results of a survey conducted on ndrugs.com for Ciprofloxacin 0.3% Thephaco are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ciprofloxacin 0.3% Thephaco. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
1 consumer reported dosesWhat doses of Ciprofloxacin 0.3% Thephaco drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Ciprofloxacin 0.3% Thephaco drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
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Information checked by Dr. Sachin Kumar, MD Pharmacology