Ciprofloxacin Actavis Pregnancy

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Pregnancy of Ciprofloxacin Actavis in details

infoPregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Contraindicated in pregnancy (safety and efficacy in women during pregnancy has not been established); Ciprofloxacin Actavis crosses the placenta, excreted in breast milk.

In experimental studies found that it causes arthropathy. In experiments on rats and mice treated with Ciprofloxacin Actavis in doses exceeding the usual daily dose for a person 6 times, adverse effects on the fetus is not revealed. In experiments on rabbits treated with oral dose of Ciprofloxacin Actavis 30 and 100 mg / kg, it is shown that the drug causes disruption of the gastrointestinal tract, leading to loss of body weight in females and increase the number of miscarriages but teratogenicity not found. When IV introduction to the doses of 20 mg / kg Ciprofloxacin Actavis did not exert toxic effects on the mother and embryo, showed no teratogenicity. The use of local forms of Ciprofloxacin Actavis in pregnancy is possible if the anticipated benefits exceed the potential risk to the fetus.

Category of the fetus by FDA - C.

Ciprofloxacin Actavis is excreted in breast milk, so the period of lactation should decide, stop taking Ciprofloxacin Actavis or breastfeeding based on the degree of importance of the use of drugs for the mother.

With careful use of local forms of Ciprofloxacin Actavis in breast-feeding (not known whether Ciprofloxacin Actavis is excreted in breast milk when applied topically).

Ciprofloxacin Actavis breastfeeding

infoWhen a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!
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There are no data on the excretion of Ciprofloxacin Actavis otic into human milk. Concentrations of orally administered Ciprofloxacin Actavis found in breast milk have ranged from 85% (at 24 hours post dose) to 214% (at 4 hours post dose) of maternal serum concentration. In one case report, an infant developed perforated pseudomembranous colitis following ingestion of Ciprofloxacin Actavis via the mother's milk. In addition, quinolone-induced cartilage erosion and arthropathies that have been observed in juvenile animals render some concern over its possible toxic effects on the developing joints of nursing infants. However, limited data indicate that systemic absorption after otic administration is extremely low. Plasma levels of Ciprofloxacin Actavis and hydrocortisone are expected to be below the level of quantitation after administration of 3 drops of suspension into the ear. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue the drug or to discontinue nursing, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Cetraxal (Ciprofloxacin Actavis otic)." WraSer Pharmaceuticals, Madison, MS.

References for breastfeeding information

  1. "Product Information. Cetraxal (Ciprofloxacin Actavis otic)." WraSer Pharmaceuticals, Madison, MS.


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References

  1. DailyMed. "CIPROFLOXACIN; DEXAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubMed Health. "Ciprofloxacin (Into the eye) (Ciloxan): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. Human Metabolome Database (HMDB). "Ciprofloxacin: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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