Clindamycin Topical/Nicotinamide Uses

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Consists of Clindamycin Topical, Nicotinamide

What is Clindamycin Topical?

Clindamycin is an antibiotic. Clindamycin topical prevents bacteria from growing on the skin.

Clindamycin topical (for the skin) is used to treat severe acne in adults and children who are at least 12 years old.

Clindamycin topical may also be used for other purposes not listed in this medication guide.

Clindamycin Topical indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Clindamycin Topical 2%, is indicated in the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or anaerobic vaginosis). Clindamycin Topical 2%, can be used to treat non-pregnant women and pregnant women during the second and third trimester.

NOTE: For purposes of this indication, a clinical diagnosis of bacterial vaginosis is usually defined by the presence of a homogeneous vaginal discharge that (a) has a pH of greater than 4.5, (b) emits a “fishy” amine odor when mixed with a 10% KOH solution, and (c) contains clue cells on microscopic examination. Gram's stain results consistent with a diagnosis of bacterial vaginosis include (a) markedly reduced or absent Lactobacillus morphology, (b) predominance of Gardnerella morphotype, and (c) absent or few white blood cells.

Other pathogens commonly associated with vulvovaginitis, eg, Trichomonas vaginalis, Chlamydia trachomatis, N. gonorrhoeae, Candida albicans, and Herpes simplex virus should be ruled out.

How should I use Clindamycin Topical?

Use Clindamycin Topical as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Clindamycin Topical.

Uses of Clindamycin Topical in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Clindamycin topical is used to treat severe acne (acne vulgaris) and vaginal infections caused by certain bacteria.

Clindamycin Topical description

An antibacterial agent that is a semisynthetic analog of lincomycin.

Clindamycin Topical dosage

Apply a thin film of Clindamycin Topical

Topical Solution, Clindamycin Topical

Topical Lotion, Clindamycin Topical

Topical Gel, or use a Clindamycin Topical

Topical Solution pledget for the application of Clindamycin Topical twice daily to affected area. More than one pledget may be used. Each pledget should be used only once and then be discarded.

Lotion: Shake well immediately before using.

Pledget: Remove pledget from foil just before use. Do not use if the seal is broken. Discard after single use.

Keep all liquid dosage forms in containers tightly closed.

How supplied

Clindamycin Topical

Topical Solution

containing clindamycin phosphate equivalent to 10 mg clindamycin per milliliter is available in the following sizes:

30 mL applicator bottle - NDC 0009-3116-01

60 mL applicator bottle - NDC 0009-3116-02

Carton of 60 single-use pledget applicators - NDC 0009-3116-14

Clindamycin Topical

Topical Gel

containing clindamycin phosphate equivalent to 10 mg clindamycin per gram is available in the following sizes:

60 gram tube - NDC 0009-3331-01

30 gram tube - NDC 0009-3331-02

Clindamycin Topical

Topical Lotion

containing clindamycin phosphate equivalent to 10 mg clindamycin per milliliter is available in the following size:

60 mL plastic squeeze bottle - NDC 0009-3329-01

Store at controlled room temperature 20° to 25°C (68° to 77°F).

Protect from freezing.

Distributed by: Pharmacia & Upjohn Company, Division of Pfizer Inc., NY, NY 10017. Revised April 2014

Clindamycin Topical interactions

See also:
What other drugs will affect Clindamycin Topical?

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Clindamycin Topical Lotion has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.

Clindamycin Topical side effects

See also:
What are the possible side effects of Clindamycin Topical?

Applies to clindamycin topical: vaginal cream, vaginal suppository

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by clindamycin topical (the active ingredient contained in Clindamycin Topical). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking clindamycin topical, check with your doctor or nurse as soon as possible:

More common:

Less common: Rare

Side Effects: Post Treatment

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

Clindamycin Topical contraindications

See also:
What is the most important information I should know about Clindamycin Topical?

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Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking clindamycin topical and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid getting this medication in your eyes. If it does get into your eyes, rinse thoroughly with water.

It may take up several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse.

Although the risk of serious side effects is low when clindamycin is applied to the skin, side effects can occur if the medication is absorbed into your bloodstream.

Before using this medication, tell your doctor if you have an intestinal disorder such as ulcerative colitis, if you have ever had eczema, or if you have ever had severe diarrhea caused by antibiotic medicine.

Nicotinamide indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

To avoid and correct vitamin deficiency, which may

result from an imbalanced or special diet, impaired

absorption, anorexia, slimming, pathological intestinal

flora, debilitating disease or therapy with drugs acting

as vitamin antagonists.

Nicotinamide syrup meets the increased vitamin requirements

during periods of intensive growth, and as a dietary

supplement in premature and newborn infants.

Uses of Nicotinamide in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Nicotinamide is used to treat vitamin B3 deficiency and inflammatory skin diseases like acne and pellagra.

Nicotinamide description

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. [PubChem]

Nicotinamide dosage

Oral

Treatment and prophylaxis of nicotinic acid deficiency

Adult: Up to 500 mg daily in divided doses. May also be given via IM or by slow IV inj.

Topical/Cutaneous

Mild to moderate inflammatory acne

Adult: As a 4% gel: Apply bid, reduce to once daily or on alternate days if irritation occurs.

Nicotinamide interactions

Nicotinamide: The clearance of primidone and carbamazepine may be reduced with the concomitant use of nicotinamide.

Zinc Oxide: The absorption of quinolones or tetracycline may be decreased with the concomitant use of zinc.

Cupric Oxide: Concomitant use of penicillamine and copper can cause decreased absorption of both substances.

Nicotinamide side effects

Allergic sensitization has been reported rarely following oral and parenteral administration of Folic Acid.

At recommended doses, nicotinamide is expected to be well tolerated. Gastrointestinal distress such as nausea or vomiting have been associated with the administration of nicotinamide or zinc at doses greater than the recommended dose of nicotinamide

Nicotinamide: Dizziness, headache, hyperglycemia, nausea, vomiting, diarrhea, elevations in liver function tests, hepatotoxicity, blurred vision, flushing, rash.

Nicotinamide contraindications

contraindicated in patients with hypersensitivity to any of its components.

Active ingredient matches for Clindamycin Topical/Nicotinamide:

Clindamycin Topical/Nicotinamide


List of Clindamycin Topical/Nicotinamide substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Acrolyn Gel (Galaxy Biotech)$ 1.19
CAREBET-CLIN GEL 1 tube / 15 GM gel each (Surecare Pharma Pvt Ltd)$ 1.59
Clindot-N Gel (Brinton Pharmaceuticals Pvt Ltd)$ 3.02
Clinka-N Gel (Intas Pharmaceuticals Ltd)$ 1.32
CLINOPAK GEL 1 tube / 20 GM gel each (Bennet Pharmaceuticals Limited)$ 0.94
Clinopak 1%/4% Gel (Bennet Pharmaceuticals Limited)$ 0.94
CLINZER 1%W/W/4%W/W GEL 1 tube / 20 GM gel each (Panzer Pharmaceuticals Pvt Ltd)$ 1.75
CLINZER LOTION 1 bottle / 25 ML lotion each (Panzer Pharmaceuticals Pvt Ltd)$ 1.13
Clinzer Gel (Panzer Pharmaceuticals Pvt Ltd)$ 1.75
Clinzer NA Lotion (Panzer Pharmaceuticals Pvt Ltd)$ 1.13
Faceclin Clindamycin phosphate 1 % w/w, Nicotinamide 4 % w/w. GEL / 10g (AHPL)$ 1.13
10g (AHPL)$ 1.13
FACECLIN 1% W/W/4% W/W GEL 1 tube / 20 GM gel each (AHPL)$ 2.06
FACECLIN topical gel 10g (AHPL)$ 1.24
Femcinol A Skin 10 gm Gel (Fem Care Pharma Limited)$ 0.93
FEMCINOL A 1% W/W/4% W/W GEL 1 tube / 10 GM gel each (Fem Care Pharma Limited)$ 1.71
FEMCINOL A 1% W/W/4% W/W GEL 1 tube / 20 GM gel each (Fem Care Pharma Limited)$ 1.71
FORACNE 10% W/W/4% W/W GEL 1 tube / 20 GM gel each (Cipla Ltd)$ 0.56
Foracne 10% w/w/4 (Cipla Ltd)$ 1.44
KLINFACE N GEL 1 tube / 10 GM gel each (Kivi Labs Ltd)$ 1.47
MYFACE 1%W/W/4%W/W GEL 1 tube / 20 GM gel each (Anhox Healthcare Pvt Ltd)$ 1.59
MYFACE GEL 1 tube / 10 GM gel each (Anhox Healthcare Pvt Ltd)$ 1.59
Myface 1% w/w/4 (Anhox Healthcare Pvt Ltd)$ 1.59
Myface Gel (Anhox Healthcare Pvt Ltd)$ 1.59
NILAC GEL 1 tube / 20 GM gel each (Micro Labs Ltd)$ 1.73
NIOCLEAN 1%/4% GEL 1 tube / 20 GM gel each (KLM Laboratories Pvt Ltd)$ 1.75

References

  1. DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN 5'-PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "nicotinamide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. PubChem. "clindamycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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