Clinivate-N Cream Overdose

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Clinivate-N Cream warnings

infoWarnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.
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Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression, with or without clinical features of Cushing’s syndrome, can occur even without occlusion. In this situation, topical steroids should be discontinued gradually under medical supervision because of the risk of adrenal insufficiency.

If infection persists, systemic chemotherapy is required.

Withdraw topical corticosteroid if there is a spread of infection.

Bacterial infection is encouraged by the warm, moist conditions induced by occlusive dressings, and the skin should be cleansed before a fresh dressing is applied.

Avoid prolonged application to the face. The face, more than other areas of the body, may exhibit atrophic changes after prolonged treatment with potent topical corticosteroids. This must be borne in mind when treating such conditions as psoriasis, discoid lupus erythematosus and severe eczema.

If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye, as glaucoma might result. If Clinivate-N Cream Cream does enter the eye, the affected eye should be bathed in copious amounts of water.

Topical corticosteroids may be hazardous in psoriasis for a number of reasons including rebound relapses, development of tolerance, risk of generalised pustular psoriasis and development of local or systemic toxicity due to impaired barrier function of the skin. If used in psoriasis careful patient supervision is important.

Extended or recurrent application may increase the risk of contact sensitisation.

Extension of infection may occur due to the masking effect of the steroid.

Following significant systemic absorption, aminoglycosides such as Neomycin (Clinivate-N Cream) can cause irreversible ototoxicity; and Neomycin (Clinivate-N Cream) has nephrotoxic potential.

In renal impairment the plasma clearance of Neomycin (Clinivate-N Cream) is reduced

Products which contain antimicrobial agents should not be diluted.

Clinivate-N Cream precautions

infoCertain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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Carcinogenicity: Long-term animal studies to determine the carcinogenicity of topical corticosteroids have not been done.

Mutagenicity: Betamethasone (Clinivate-N Cream) was found to be genotoxic in in vitro human peripheral blood lymphocyte chromosome aberration assay with metabolic activation and in vivo mouse bone marrow micronucleus assay.

Use in pregnancy: Betamethasone (Clinivate-N Cream):

Topical corticosteroids, especially the more potent ones, should not be used extensively in large amounts or for protracted periods in pregnant patient or in patients who are planning to become pregnant. Adequate and well-controlled studies in humans have not been done.

Neomycin (Clinivate-N Cream): Problems in humans have not been documented.

Use in lactation: Betamethasone (Clinivate-N Cream): It is not known whether topical corticosteroids are distributed into breast milk. However, problems in humans have not been documented.

Topical corticosteroids should not be applied to the breasts prior to nursing.

Neomycin (Clinivate-N Cream): It is not known whether topical Neomycin (Clinivate-N Cream) is distributed into breast milk. However, problems in humans have not been documented.

Use in children: Betamethasone (Clinivate-N Cream): Children and adolescents have a large skin surface area to the body weight ratio and less developed, thinner skin, which may result in absorption of greater amounts of topical corticosteroids compared with older patients. Absorption also is greater in premature infants than in full term newborns, due to inadequate development of the stratum corneum. Neomycin (Clinivate-N Cream): No information is available on the relationship of age to the effects of topical Neomycin (Clinivate-N Cream) in pediatric patients.

Use in the

Elderly: Betamethasone (Clinivate-N Cream): Although appropriate studies with topical corticosteroids have not been performed in the geriatric population, geriatrics-specific problems are not expected to limit the usefulness of topical corticosteroids in elderly.

Neomycin (Clinivate-N Cream): No information is available on the relationship of age to the effects of topical Neomycin (Clinivate-N Cream) in geriatric patients.


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References

  1. DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. DrugBank. "neomycin". http://www.drugbank.ca/drugs/DB00452 (accessed September 17, 2018).

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