Clinzen Pregnancy

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Pregnancy of Clinzen in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.

Clinzen crosses the placenta and can be detected in the cord blood and fetal tissue (Philipson 1973; Weinstein 1976). Clinzen injection contains benzyl alcohol which may also cross the placenta.

Clinzen pharmacokinetics are not affected by pregnancy (Philipson 1976; Weinstein 1976).

Clinzen is recommended for use in pregnant women for the prophylaxis of group B streptococcal disease in newborns (alternative therapy) (ACOG 782 2019); prophylaxis and treatment of Toxoplasma gondii encephalitis (alternative therapy), or Pneumocystis pneumonia (PCP) (alternative therapy) (HHS [OI adult ] 2019); bacterial vaginosis (CDC [Workowski 2015]); anthrax (Meaney-Delman 2014); or malaria (CDC 2019). Clinzen is also one of the antibiotics recommended for prophylactic use prior to cesarean delivery and may be used in certain situations prior to vaginal delivery in women at high risk for endocarditis (ACOG 199 2018).

Clinzen breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Use is not recommended; an alternate drug may be preferred Excreted into human milk: Yes Comments: Infants should be monitored for side effects on the gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash), or rarely, blood in the stool.

A report of bloody stools in a 5-day-old breastfed infant may have been caused by the concurrent maternal administration of IV Clinzen and gentamicin. Symptoms resolved 24 hours after breastfeeding was stopped and no further difficulties reported when breastfeeding was resumed on day 6 of age, after the maternal antibiotics were stopped. Concentrations in breast milk after oral administration of Clinzen 150 mg orally three times a day after at least 1 week of therapy have been reported at 1.2 mg/L (average, 6 hours after dosing) and at 0.3 to 1.2 mg/L between one and 6 hours after a single 150 mg dose. Peak concentrations in breast milk after oral dosing of 300 mg every six hours have been reported at 1.3 mg/L after 3.5 hours and 1.8 mg/L after 2 hours. Peak concentrations in breast milk after IV administration of Clinzen 600 mg IV every six hours have been reported at 2.65 mg/L after 3.5 hours and 3.1 mg/L after 30 minutes.

See references

References for pregnancy information

  1. Ugwumadu A, Manyonda I, Reid F, Hay P "Effect of early oral Clinzen on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomised controlled trial." Lancet 361 (2003): 983-8
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. "Product Information. Cleocin (Clinzen)." Pharmacia and Upjohn, Kalamazoo, MI.
  4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

References for breastfeeding information

  1. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
  2. Department of Adolescent and Child Health and Development. UNICEF. World Health Organization "Breastfeeding and maternal medication: recommendations for drugs in the eleventh Who model list of essential drugs. Available from: URL:" ():
  3. Smith JA, Morgan JR, Rachlis AR, Papsin FR "Clinzen in human breast milk." Can Med Assoc J 112 (1975): 806
  4. "Product Information. Cleocin (Clinzen)." Pharmacia and Upjohn, Kalamazoo, MI.
  5. Mann CF "Clinzen and breast-feeding." Pediatrics 66 (1980): 1030-1
  6. Cerner Multum, Inc. "Australian Product Information." O 0
  7. Matsuda S "Transfer of antibiotics into maternal milk." Biol Res Pregnancy Perinatol 5 (1984): 57-60
  8. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL:" ([cited 2013 -]):
  9. Steen B, Rane A "Clinzen passage into human milk." Br J Clin Pharmacol 13 (1982): 661-4



  1. PubMed Health. "Clindamycin (Into the vagina) (Cleocin Vaginal): This section provide the link out information of drugs collectetd in PubMed Health. ". (accessed September 17, 2018).
  2. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". (accessed September 17, 2018).
  3. LiverTox. "Clindamycin: LIVERTOX provides up-to-date, accurate, and easily accessed information on the diagnosis, cause, frequency, patterns, and management of liver injury attributable to prescription and nonprescription medications, herbals and dietary supplements. ". (accessed September 17, 2018).


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