Clocip DUSTING POWD Pregnancy

• Pregnancy of Clocip DUSTING POWD in details
• Clocip DUSTING POWD breastfeeding
• Clocip DUSTING POWD reviews

Pregnancy of Clocip DUSTING POWD in details

Pregnancy predisposes patients to the development of vaginal candidiasis due to changes in the vaginal tract. Clocip DUSTING POWD has been used in several clinical trials for the treatment of vaginal candidiasis during the second and third trimester without evidence of fetal harm. One trial included 57 patients in their first trimester. Again no adverse effects were attributed to Clocip DUSTING POWD. In a review of 229,101 deliveries to Michigan Medicaid patients, 2624 first-trimester exposures to Clocip DUSTING POWD and 8590 exposures any time during pregnancy were recorded. A total of 118 birth defects were reported with first trimester exposure (112 expected) and included (observed/expected) 27/26 cardiovascular defects, 3/1 spina bifida, 4/4 oral clefts, 9/6 polydactyly, 1 limb reduction, and 6/6 hypospadias. (written communication, Franz Rosa, MD, Food and Drug Administration, 1994) These data do not support an association between first-trimester Clocip DUSTING POWD use and birth defects.

Clocip DUSTING POWD has been assigned to pregnancy category C by the FDA when given as oral troches, and pregnancy category B when used intravaginally or topically. Animals given high doses intravaginally and orally have not shown evidence of teratogenicity. In clinical trials involving women in their second and third trimester, Clocip DUSTING POWD treatment of vaginal candidiasis has not been associated with fetal harm. Clocip DUSTING POWD use has not been well studied during the first trimester. Clocip DUSTING POWD is only recommended for use during pregnancy when benefit outweighs risk.

Clocip DUSTING POWD breastfeeding

There are no data on the excretion of Clocip DUSTING POWD into human milk.

See references

References for pregnancy information

1. "Product Information. Mycelex (Clocip DUSTING POWD)." Bayer, West Haven, CT.
2. Haram K, Digranes A "Vulvovaginal candidiasis in pregnancy treated with Clocip DUSTING POWD." Acta Obstet Gynecol Scand 57 (1978): 453-5
3. Frerich W, Gad A "The frequency of Candida infections in pregnancy and their treatment with Clocip DUSTING POWD." Curr Med Res Opin 4 (1977): 640-4
4. Tan CG, Good CS, Milne LJ, Loudon JD "A comparative trial of six day therapy with Clocip DUSTING POWD and nystatin in pregnant patients with vaginal candidiasis." Postgrad Med J 50 Suppl 1 (1974): 102-5
5. Lindeque BG, van Niekerk WA "Treatment of vaginal candidiasis in pregnancy with a single Clocip DUSTING POWD 500 mg vaginal pessary." S Afr Med J 65 (1984): 123-4

References for breastfeeding information

1. "Product Information. Mycelex (Clocip DUSTING POWD)." Bayer, West Haven, CT.

References

1. DailyMed. "BETAMETHASONE DIPROPIONATE; CLOTRIMAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubMed Health. "Mycelex: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
3. Human Metabolome Database (HMDB). "Clotrimazole: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology