Cloderm 1% Overdose

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What happens if I overdose Cloderm 1%?

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately. Cloderm 1% solution may be harmful if swallowed.

Proper storage of Cloderm 1% solution:

Store Cloderm 1% solution at room temperature, 59 to 86 degrees F (15 to 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cloderm 1% solution out of the reach of children and away from pets.

Overdose of Cloderm 1% in details

When a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
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No reports are available on cases of overdose with Cloderm 1% 1% w/w. There is no specific antidote.

Topical Cloderm 1% is intended for cutaneous use only.

In the case of cutaneous overdose patients should be managed by symptomatic care; patients should wash off the product with water and cleanser, discontinue use, and see the physician so appropriate therapy can be implemented as needed. In the case of ingestion of an overdose, patients should see the physician and be managed by symptomatic and supportive care.

What should I avoid while taking Cloderm 1%?

There are no restrictions on foods, beverages, or activities during treatment with Cloderm 1% unless your doctor directs otherwise.

Cloderm 1% warnings

Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.

If irritation or sensitivity develops with the use of Cloderm 1% Cream, treatment should be discontinued and appropriate therapy instituted.

Pregnancy & lactation:

Pregnancy Category B

The disposition of 14C-Cloderm 1% has been studied in humans and animals. Cloderm 1% is very poorly absorbed following dermal application or intravaginal administration to humans.

In clinical trials, use of vaginally applied Cloderm 1% in pregnant women in their second and third trimesters has not been associated with ill effects. There are, however, no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy.

Studies in pregnant rats with intravaginal doses up to 100 mg/kg have revealed no evidence of harm to the fetus due to Cloderm 1%.

High oral doses of Cloderm 1% in rats and mice ranging from 50 to 120 mg/kg resulted in embryotoxicity (possibly secondary to maternal toxicity), impairment of mating, decreased litter size and number of viable young and decreased pup survival to weaning. However, Cloderm 1% was not teratogenic in mice, rabbits and rats at oral doses up to 200, 180 and 100 mg/kg, respectively.

Oral absorption in the rat amounts to approximately 90% of the administered dose.

Because animal reproduction studies are not always predictive of human response, this drug should be used only if clearly indicated during the first trimester of pregnancy.

Nursing Mothers

It is not known whether this drug is excreted in human milk, caution should be exercised when Cloderm 1% is used by a nursing woman.

Pediatric Use

Safety and effectiveness in children have been established for Cloderm 1% when used as indicated and in the recommended dosage.

What should I discuss with my healthcare provider before taking Cloderm 1%?

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Cloderm 1%, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to Cloderm 1% or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although Cloderm 1% has not been shown to cause different side effects or problems in children than it does in adults, it should not be given to children under 3 years of age since they may be too young to use the lozenges safely.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of Cloderm 1% lozenges in the elderly with use in other age groups, Cloderm 1% is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking Cloderm 1%, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using Cloderm 1% with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of Cloderm 1%. Make sure you tell your doctor if you have any other medical problems, especially:

The presence of other medical problems may affect the use of Cloderm 1%. Make sure you tell your doctor if you have the following medical condition:

Cloderm 1% precautions

Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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General:

If irritation or sensitivity develops with the use of Cloderm 1% Cream, treatment should be discontinued and appropriate therapy instituted.

Information for Patients :

The patient should be advised to:

1.
Use the medication for the full treatment time even though the symptoms may have improved. Notify the physician if there is no improvement after four weeks of treatment.
2.
Inform the physician if the area of application shows signs of increased irritation (redness, itching, burning, blistering, swelling, oozing) indicative of possible sensitization.
3.
Avoid the use of occlusive wrappings or dressings.
4.
Avoid sources of infection or reinfection.

Laboratory Tests

If there is lack of response to Cloderm 1% Cream, appropriate microbiological studies should be repeated to confirm the diagnosis and rule out other pathogens before instituting another course of antimycotic therapy.

Drug Interactions

Synergism or antagonism between Cloderm 1% and nystatin, or amphotericin B, or flucytosine against strains of C. albicans has not been reported.

Carcinogenesis, Mutagenesis, Impairment of Fertility

An 18-month oral dosing study with Cloderm 1% in rats has not revealed any carcinogenic effect.

In tests for mutagenesis, chromosomes of the spermatophores of Chinese hamsters which had been exposed to Cloderm 1% were examined for structural changes during the metaphase. Prior to testing, the hamsters had received five oral Cloderm 1% doses of 100 mg/kg body weight. The results of this study showed that Cloderm 1% had no mutagenic effect.

Usage in Pregnancy: Pregnancy Category B

The disposition of 14C-Cloderm 1% has been studied in humans and animals. Cloderm 1% is very poorly absorbed following dermal application or intravaginal administration to humans.

In clinical trials, use of vaginally applied Cloderm 1% in pregnant women in their second and third trimesters has not been associated with ill effects. There are, however, no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy.

Studies in pregnant rats with intravaginal doses up to 100 mg/kg have revealed no evidence of harm to the fetus due to Cloderm 1%.

High oral doses of Cloderm 1% in rats and mice ranging from 50 to 120 mg/kg resulted in embroyotoxicity (possible secondary to maternal toxicity), impairment of mating, decreased litter size and number of viable young and decreased pup survival to weaning. However, Cloderm 1% was not teratogenic in mice, rabbits and rats at oral doses up to 200, 180 and 100 mg/kg, respectively.

Oral absorption in the rat amounts to approximately 90% of the administered dose.

Because animal reproduction studies are not always predictive of human response, this drug should be used only if clearly indicated during the first trimester of pregnancy.

Nursing Mothers

It is not known whether this drug is excreted in human milk, caution should be exercised when Cloderm 1% is used by a nursing woman.

Pediatric Use

Safety and effectiveness in children have been established for Cloderm 1% when used as indicated and in the recommended dosage.

What happens if I miss a dose of Cloderm 1%?

When you miss a dose, you should take it as soon as you remember, but you should take care that it should be well spaced from the next dose. You should not take an extra dose at the time of the second dose as it will become a double dose. The double dose can give unwanted side effects, so be careful. In chronic conditions or when you have a serious health issue, if you miss a dose, you should inform your health care provider and ask his suggestion.

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.


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References

  1. DailyMed. "BETAMETHASONE DIPROPIONATE; CLOTRIMAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DrugBank. "clotrimazole". http://www.drugbank.ca/drugs/DB00257 (accessed September 17, 2018).
  3. MeSH. "Anti-Infective Agents, Local". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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