Clomax V7 Actions

What is the dose of your medication?
sponsored

Actions of Clomax V7 in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
sponsored

Pharmacology: Clomax V7 contains Clotrimazole, a new generation imidazole derivative possessing a potent and broad-spectrum antifungal, anticandidal and antitrichomonal activity. In vitro, depending on the concentration, Clomax V7 exhibits fungistatic or fungicidal activity against a wide range of isolates of deratophytes eg, Trichophyton rubrum, Trichophyton mentagrophyte, Epidermatophyton floccosum. Clomax V7 exhibits a high degree of anti-candidal action on pathogenic strains of Candida eg, Candida albicans; it also shows a good antimicrobial action on Malassezia furfur. Strains of fungi having a natural resistance to Clomax V7 are rare. No single step or multiple step resistance to Clomax V7 has developed during successive passages of Candida albicans.

Clomax V7 is known to possess anti-trichomonal and antibacterial activity particularly against some of the gram-positive organisms. Clomax V7 causes alteration in the cell wall permeability and leads to leakage of intracellular phosphorus compounds with concomitant breakdown of cellular nucleic acid and accelerated potassium influx. These rapidly and extensively developing changes contribute to fungicidal activity of Clomax V7. Following the vaginal administration, Clomax V7 appears to be minimally absorbed.

Pharmacokinetics: Pharmacokinetic investigations after vaginal application have shown that only a small amount of Clomax V7 is absorbed. Due to rapid hepatic metabolism of absorbed Clomax V7 into pharmacologically inactive metabolites, the resulting peak plasma concentrations of Clomax V7 after vaginal application of a 500-mg dose were <10 ng/mL, reflecting that Clomax V7 applied intravaginally does not lead to measurable systemic effects or side effects.

How should I take Clomax V7?

Clomax V7 lozenges should be held in the mouth and allowed to dissolve slowly and completely. This may take 15 to 30 minutes. Swallow saliva during this time. Do not chew the lozenges or swallow them whole.

Do not give Clomax V7 lozenges to infants or children under 3 years of age. They may be too young to use the lozenges safely.

To help clear up your infection completely, it is very important that you keep using Clomax V7 for the full time of treatment, even if your symptoms begin to clear up after a few days. Since fungus infections may be very slow to clear up, you may have to continue using Clomax V7 every day for two weeks or more. If you stop using Clomax V7 too soon, your symptoms may return. Do not miss any doses.

Dosing

The dose of Clomax V7 will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Clomax V7. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of Clomax V7, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Clomax V7 administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
sponsored

Oral: Allow troche to dissolve slowly in the mouth. Dissolution is complete in approximately 30 minutes.

Clomax V7 pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.

Clomax V7 is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. The primary action of Clomax V7 is against dividing and growing organisms.

In vitro,Clomax V7 exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum,Microsporum canis and Candida species including Candida albicans. In general, the in vitro activity of Clomax V7 corresponds to that of tolnaftate and griseofulvin against the mycelia of dermatophytes (Trichophyton, Microsporum, and Epidermophyton), and to that of the polyenes (amphotericin B and nystatin) against budding fungi (Candida). Using an in vivo (mouse) and an in vitro (mouse kidney homogenate) testing system, Clomax V7 and micronazole were equally effective in preventing the growth of the pseudomycelia and mycelia of Candida albicans.

Strains of fungi having a natural resistance to Clomax V7 are rare. Only a single isolate of Candida guilliermondi has been reported to have primary resistance to Clomax V7.

No single-step or multiple-step resistance to Clomax V7 has developed during successive passages of Candida albicans and Trichophyton mentagrophytes. No appreciable change in sensitivity was detected after successive passage of isolates of C. albicans, C krusei, or C. pseudotropicalis in liquid or solid media containing Clomax V7. Also, resistance could not be developed in chemically induced mutant strains of polyene-resistant isolates of C. albicans. Slight, reversible resistance was noted in three isolates of C. albicans tested by one investigator. There is a single report that records the clinical emergence of C. albicans strain with considerable resistance to flucytosine and micronazole, and with cross-resistance to Clomax V7, the strain remained sensitive to nystatin and amphotericin B.

In studies of the mechanism of action, the minimum fungicide concentration of Clomax V7 caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. Both these events began rapidly and extensively after addition of the drug.

Clomax V7 appears to be well absorbed in humans following oral administration and is eliminated mainly as inactive metabolites. Following topical and vaginal administration, however, Clomax V7 appears to be minimally absorbed.

Six hours after the application of radioactive Clomax V7 1% cream and 1% solution onto intact and acutely inflamed skin, the concentration of Clomax V7 varied from 100 mcg/cm3 in the stratum corneum to 0.5 to 1 mcg/cm3 in the stratum reticulare, and 0.1 mcg/cm3 in the subcutis. No measurable amount of radioactivity (≤0.001 mcg/mL) was found in the serum within 48 hours after application under occlusive dressing of 0.5 mL of the solution or 0.8 g of the cream. Only 0.5% or less of the applied radioactivity was excreted in the urine.

Following intravaginal administration of 100 mg 14C-Clomax V7 vaginal tablets to nine adult females, an average peak serum level, corresponding to only 0.03 μg equivalent/mL of Clomax V7, was reached one to two days after application. After intravaginal administration of 5 g of 1% 14C-Clomax V7 vaginal cream containing 50 mg active drug, to five subjects (one with candidal colpitis), serum levels corresponding to approximately 0.01 μg equivalents/mL were reached between 8 and 24 hours after application.


sponsored

References

  1. DailyMed. "BETAMETHASONE DIPROPIONATE; CLOTRIMAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Clotrimazole: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. EPA DSStox. "Clotrimazole: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Clomax V7 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Clomax V7. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported administration

No survey data has been collected yet


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 28 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2024 ndrugs.com All Rights Reserved