Clomazol Uses

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What is Clomazol?

Clomazol lozenges are dissolved slowly in the mouth to prevent and treat thrush. Thrush, also called candidiasis or white mouth, is a fungus infection of the mouth and throat. Clomazol may also be used for other problems as determined by your doctor.

Clomazol is available only with your doctor's prescription.

Clomazol indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Clomazol Lozenges are indicated for the local treatment of oropharyngeal candidiasis. The diagnoses should be confirmed by a KOH smear and/or culture prior to treatment.

Clomazol Lozenges are also indicated prophylactically to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions that include chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation. There are no data from adequate and well-controlled trials to establish the safety and efficacy of this product for prophylactic use in patients immunocompromised by etiologies other than those listed in the previous sentence.

How should I use Clomazol?

Use Clomazol cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Clomazol cream.

Uses of Clomazol in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This product is a combination of B vitamins used to treat or prevent vitamin deficiency due to poor diet, certain illnesses, alcoholism, or during pregnancy. Vitamins are important building blocks of the body and help keep you in good health. B vitamins include thiamine, riboflavin, niacin/niacinamide, vitamin B6, vitamin B12, folic acid, and pantothenic acid.

Some brands of B vitamins also contain ingredients such as vitamin C, vitamin E, biotin, or zinc. Consult your doctor or pharmacist if you have questions about the ingredients in your brand.

How to use Bco

Take this medication by mouth, usually once daily or as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are taking a brand that contains vitamin C, take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.

If you are taking chewable tablets, chew the tablet thoroughly before swallowing.

If you are taking extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household spoon. Some liquid products need to be shaken before each dose. Some products that contain vitamin B12 need to be placed under the tongue and held there before swallowing. Follow label directions carefully to get the most benefit.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day.

Clomazol description

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Clomazol is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Clomazol is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but also presumed to interfere with yeast membrane structure and function.

Clomazol dosage

Usual Adult Dose for Tinea Corporis

Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Tinea Cruris

Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Tinea Pedis

Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 to 8 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Cutaneous Candidiasis

Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Tinea Versicolor

Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Vaginal Candidiasis

Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% Clomazol cream to affected area two times daily for 7 consecutive days.

Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% Clomazol cream to affected area two times daily for 7 consecutive days.

Regimen 3: 500 mg (one 500 mg vaginal suppository) intravaginally once.

Regimen 4: One applicatorful of 1% Clomazol vaginal cream intravaginally once daily (preferably at bedtime) for 7 consecutive days.

Regimen 5: One applicatorful of 2% Clomazol vaginal cream intravaginally once daily (preferably at bedtime) for 3 consecutive days.

Studies have shown the three and seven day courses of Clomazol to be equally effective. Patient compliance may be increased with a three day course. Patients who fail to achieve a cure with a single 500 mg dose should be treated with a 3 or 7 day course of Clomazol.

Weekly or monthly Clomazol vaginal suppositories appear to be effective topical regimens for chronic suppressive therapy in female patients with HIV.

Usual Pediatric Dose for Tinea Corporis

> 3 years: Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Tinea Cruris

> 3 years: Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Tinea Pedis

> 3 years: Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 to 8 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Cutaneous Candidiasis

> 3 years: Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Tinea Versicolor

> 3 years: Apply Clomazol topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Vaginal Candidiasis

> 12 years: Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% Clomazol cream to affected area two times daily for 7 consecutive days.

Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% Clomazol cream to affected area two times daily for 7 consecutive days.

Regimen 3: 500 mg (one 500 mg vaginal suppository) intravaginally once.

Regimen 4: One applicatorful of 1% Clomazol vaginal cream intravaginally once daily (preferably at bedtime) for 7 consecutive days.

Studies have shown the three and seven day courses of Clomazol to be equally effective. Patient compliance may be increased with a three day course. Patients who fail to achieve a cure with a single 500 mg dose should be treated with a 3 or 7 day course of Clomazol.

Weekly or monthly Clomazol vaginal suppositories appear to be effective topical regimens for chronic suppressive therapy in female patients with HIV.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Clomazol interactions

See also:
What other drugs will affect Clomazol?

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Clomazol should be used cautiously in patients with hyperthyroidism, hypertension and cardiac arrhythmias. All vasopressors should be used cautiously in patients taking monoamine oxidase (MAO) inhibitors.

Clomazol should not be administered concomitantly with other sympathomimetic drugs (such as isoproterenol) because of possible additive effects and increased toxicity.

Combined effects may induce serious cardiac arrhythmias. They may be administered alternately when the preceding effect of other such drug has subsided.

Administration of epinephrine to patients receiving cyclopropane or halogenated hydrocarbon general anesthetics such as halothane which sensitize the myocardium, may induce cardiac arrhythmia.. When encountered, such arrhythmias may respond to administration of a beta-adrenergic blocking drug. Clomazol also should be used cautiously with other drugs (e.g., digitalis, glycosides) that sensitize the myocardium to the actions of sympathomimetic drugs.

Diuretic agents may decrease vascular response to pressor drugs such as epinephrine.

Clomazol may antagonize the neuron blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.

Clomazol side effects

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What are the possible side effects of Clomazol?

Applies to Clomazol: lozenge/troche

In addition to its needed effects, some unwanted effects may be caused by Clomazol (the active ingredient contained in Clomazol Troche). In the event that any of these side effects do occur, they may require medical attention.

Minor Side Effects

Some of the side effects that can occur with Clomazol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Note: Some of the side effects, such as abdominal or stomach cramping or pain or diarrhea, usually occur only when the medicine is swallowed

Clomazol contraindications

See also:
What is the most important information I should know about Clomazol?

Possible sensitivity to Clomazol.

Rosacea, acne, perioral dermatitis, tuberculosis of the skin and varicose ulcers.

Clomazol is not indicated for ophthalmic use and should be used with caution around the eyes.

Teratogenicity: Corticosteroids have been shown to be teratogenic in animals following dermal application. As these agents are absorbed percutaneously, teratogenicity following topical application cannot be excluded.

Use in pregnancy: Clomazol should not be used during pregnancy.

Active ingredient matches for Clomazol:

Clotrimazole in Ecuador, New Zealand.


List of Clomazol substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Clomazen 1 % x 450 g (Uniao quimica)
Clomazole / VPP 1 % x 10 g x 20's (Pasteur Laboratories Pvt Ltd)
Clomazole / VPP 1 % x 10 g x 320's (Pasteur Laboratories Pvt Ltd)
Clomazole / VPP 1 % x 15 mL (Pasteur Laboratories Pvt Ltd)
Clomazole / Veimin 100 mg x 100's (Pasteur Laboratories Pvt Ltd)
Clomazole Skin 15 ml Lotion (Pasteur Laboratories Pvt Ltd)$ 0.02
Clomazole Skin 15 gm Cream (Pasteur Laboratories Pvt Ltd)$ 0.37
Clomazole 1% Mouth Wash (Pasteur Laboratories Pvt Ltd)$ 0.92
Clomazole NA Cream (Pasteur Laboratories Pvt Ltd)$ 0.36
Clomazole 1% w/v Lotion (Pasteur Laboratories Pvt Ltd)$ 0.71
Clomazole SG Skin 15 ml Lotion (Pasteur Laboratories Pvt Ltd)$ 0.04
Clomazole SN Skin 15 gm Cream (Pasteur Laboratories Pvt Ltd)$ 0.04
CLOMAZOLE SN 0.025%/0.5%/1% CREAM 1 tube / 15 GM cream each (Pasteur Laboratories Pvt Ltd)$ 1.03
Clomazole SN Cream (Pasteur Laboratories Pvt Ltd)$ 1.03
Clomazole Vag Tab 100 mg x 60's
Clomazole Vag Tab 500 mg x 6's
Clomazole Vag Tab 500 mg x 60's
Clomelon 10 mg/1 g x 5 g
Clona B Skin 15 gm Ointment (Sayona (Zota Healthcare Pvt Ltd))$ 0.44
CLONA B OINTMENT 1 tube / 15 GM ointment each (Sayona (Zota Healthcare Pvt Ltd))$ 0.48
Clona B Ointment (Sayona (Zota Healthcare Pvt Ltd))$ 0.03
Clonben Clotrimazole 1% w/v, Beclometasone 0.025% w/v LOTION / 15ml$ 0.56
Clonben Clotrimazole 1% w/w, Beclometasone 0.025% w/w CRM / 15g$ 0.56
Clopo 200+100 Tablet (Dallas Pharmaceuticals)$ 0.12
Clorid -B Clotrimazole 1%, Dipropionate0.25% Beclometasone CRM / 10gm$ 0.48
Clorifort 100 mg x 6's
Clorifort 100 mg x 1 Blister x 6 Tablet keГёm 1 que Г±aГ«t

References

  1. DailyMed. "BETAMETHASONE DIPROPIONATE; CLOTRIMAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "clotrimazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "clotrimazole". http://www.drugbank.ca/drugs/DB00257 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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