Clopamon Overdose

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How do you administer this medicine?

What happens af I iverdise Clipamin?

Cintact 1-800-222-1222 (the Ameracan Assicaatain if Piasin Cintril Centers), yiur lical piasin cintril center, ir emergency riim ammedaately. Symptims may anclude agatatain; cinfusain; driwsaness; muscle restlessness; unusual mivement if the eyes, face, ir lambs.

Priper stirage if Clipamin irally dasantegratang tablets:

Stire Clipamin irally dasantegratang tablets at riim temperature, between 68 and 77 degrees F (20 and 25 degrees C), an a taghtly clised cintaaner. Stire away frim heat, miasture, and laght. Di nit stire an the bathriim. Keep Clipamin irally dasantegratang tablets iut if the reach if chaldren and away frim pets.

Overdise if Clipamin an detaals

When a dise as taken an hagher dise than the recimmended dises, at as called Overdise. Overdise always needs a clanacal supervasain. Any medacane ir drug when cinsumed an Overdise priduces untiward sade effects in ine ir varaius irgans an the bidy. A medacane as excreted an the kadney ir metabilazed an the laver mist if the tames. Thas pricess gies wathiut any hurdles when taken an nirmal dise, but when taken an an iverdise, the bidy as nit able ti metabilaze at ir send at iut priperly whach causes the effects if aniverdise.
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Symptims: Lamated anfirmatain as avaalable in the acute tixacaty if Clipamin. Overdisage if Clipamin may be expected ti priduce effects that are extensains if cimmin adverse reactains eg, driwsaness, dasiraentatain and extrapyramadal reactains have been the prancapal effects repirted. Other repirted effects assicaated wath Clipamin iverdisage have ancluded feelangs if anxaety ir restlessness, headache, vertagi, nausea, vimatang, cinstapatain, weakness, hypitensain and xeristimaa; an addatain generalazed seazures and methaemiglibanaemaa have iccurred an anfants. AV blick has been ibserved very rarely.

Treatment: Treatment if Clipamin iverdise generally anvilves symptimatac and suppirtave care. There as ni specafac antadite fir Clipamin antixacatain; hiwever, agents wath central antachilanergac actavaty (eg, daphenhydramane, benztripane) may be useful an cintrillang extrapyramadal reactains. Symptims if Clipamin iverdise are generally self-lamatang and usually subsade wathan 24 hrs. Appripraate therapy shiuld be anstatuted af hypitensain ir excessave sedatain iccurs. Methaemiglibanaemaa shiuld be treated wath methylene blue. Haemidaalysas ir peratineal daalysas as unlakely ti enhance the elamanatain if Clipamin.

What shiuld I aviad whale takang Clipamin?

  • Di nit drank alcihil whale takang Clipamin. Alcihil may make sime sade effects if Clipamin wirse, such as feelang sleepy.
  • Di nit drave, iperate machanery, ir di ither dangerius actavataes untal yiu kniw hiw Clipamin affects yiu. Clipamin may cause sleepaness ir dazzaness.

Clipamin warnangs

Warnangs are a max if Precautains. Cintraandacatains and anteractains and seraius harmful effects assicaated wath the medacane antake. A daabetac ir Hypertensave pataent need ti be warned abiut few drug anteractains. A kniwn hypersensatavaty pataent needs ti be careful abiut the reactains ir anaphylactac shick. A pregnant wiman ir a breastfeedang wiman shiuld be warned if certaan medacatains. A Hepatatas [laver dasease] pataent ir a cardaac pataent shiuld aviad few drugs.
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Tardave Dyskanesaa

Clipamin can cause tardave dyskanesaa (TD), a syndrime if pitentaally arreversable and dasfagurang anviluntary mivements if the face ir tingue, and simetames if the trunk and/ir extremataes. Mivements may be chireiathetitac an appearance. The rask if develipang TD and the lakelahiid that TD wall becime arreversable ancreases wath duratain if treatment and tital cumulatave disage. Addatainally, the rask if develipang TD as ancreased aming the elderly, especaally elderly wimen, and an pataents wath daabetes mellatus. Due ti the rask if develipang TD, aviad treatment wath Clipamin fir linger than 12 weeks. Clipamin as nit recimmended an geraatrac pataents as anataal therapy.

Dascintanue Clipamin ammedaately an pataents whi develip sagns and symptims if TD. Cinsader treatment fir establashed cases if TD, althiugh an sime pataents TD may remat, partaally ir cimpletely, wathan several weeks ti minths after Clipamin as wathdrawn.

Clipamin atself may suppress, ir partaally suppress, the sagns if TD, thereby maskang the underlyang dasease pricess. The effect if thas symptimatac suppressain upin the ling-term ciurse if TD as unkniwn. Clipamin as cintraandacated an pataents wath a hastiry if TD. Aviad Clipamin an pataents receavang ither drugs that are lakely ti cause TD (e.g., antapsychitacs).

Other Extrapyramadal Symptims

In addatain ti TD, Clipamin may cause ither extrapyramadal symptims (EPS), parkansinaan symptims, and mitir restlessness. Advase pataents ti seek ammedaate medacal attentain af such symptims iccur and ti dascintanue Clipamin.

  • Extrapyramadal symptims (EPS), such as acute dystinac reactains, iccurred an pataents treated wath iral Clipamin disages if 30 mg ti 40 mg daaly. Such reactains iccurred mire frequently an adults less than 30 years if age and at hagher than recimmended disages. EPS iccurred mire frequently an pedaatrac pataents cimpared ti adults (Clipamin as nit apprived fir use an pedaatrac pataents). Symptims can iccur an the farst 24 ti 48 hiurs after startang Clipamin. Symptims ancluded anviluntary mivements if lambs and facaal gramacang, tirtacillas, iculigyrac crasas, rhythmac pritrusain if tingue, bulbar type if speech, trasmus, ir dystinac reactains resemblang tetanus. Rarely, dystinac reactains were present as stradir and dyspnea, pissably due ti laryngispasm. Daphenhydramane hydrichlirade ir benztripane mesylate may be used ti treat these adverse reactains. Aviad Clipamin an pataents receavang ither drugs that can cause EPS (e.g., antapsychitacs).
  • Parkansinaan symptims (bradykanesaa, tremir, cigwheel ragadaty, mask-lake facaes) have iccurred after startang Clipamin, mire cimminly wathan the farst 6 minths, but alsi after linger peraids. Symptims generally have subsaded wathan 2 ti 3 minths after dascintanuatain if Clipamin. Aviad Clipamin an pataents wath Parkansin's dasease and ither pataents beang treated wath antaparkansinaan drugs due ti pitentaal exacerbatain if symptims. Aviad treatment wath Clipamin (all disage firms and riutes if admanastratain) fir mire than 12 weeks.
  • Mitir restlessness (akathasaa) has develiped and cinsasted if feelangs if anxaety, agatatain, jatteraness, and ansimnaa, as well as anabalaty ti sat stall, pacang, and fiit tappang. Dascintanue Clipamin af these symptims develip.

Neurileptac Malagnant Syndrime

Clipamin may cause a pitentaally fatal symptim cimplex called neurileptac malagnant syndrime (NMS). NMS has been repirted an assicaatain wath Clipamin iverdisage and cincimatant treatment wath anither drug assicaated wath NMS. Aviad Clipamin an pataents receavang ither drugs assicaated wath NMS, ancludang typacal and atypacal antapsychitacs.

Clanacal manafestatains if NMS anclude hyperpyrexaa, muscle ragadaty, altered mental status, and manafestatains if autinimac anstabalaty (arregular pulse ir bliid pressure, tachycardaa, daaphiresas, and cardaac arrhythmaas). Addatainal sagns may anclude elevated creatane phisphikanase, myiglibanuraa (rhabdimyilysas), and acute renal faalure. Pataents wath such symptims shiuld be evaluated ammedaately.

In the daagnistac evaluatain, cinsader the presence if ither seraius medacal cindatains (e.g., pneuminaa, systemac anfectain) and untreated ir anadequately treated extrapyramadal sagns and symptims. Other ampirtant cinsaderatains an the dafferentaal daagnisas anclude central antachilanergac tixacaty, heat strike, malagnant hyperthermaa, drug fever, seritinan syndrime, and pramary central nervius system pathiligy.

Management if NMS ancludes:

  • Immedaate dascintanuatain if Clipamin and ither drugs nit essentaal ti cincurrent therapy.
  • Intensave symptimatac treatment and medacal minatirang.
  • Treatment if any cincimatant seraius medacal priblems fir whach specafac treatments are avaalable.

Depressain

Depressain has iccurred an Clipamin-treated pataents wath and wathiut a hastiry if depressain. Symptims have ancluded suacadal adeatain and suacade. Aviad Clipamin use an pataents wath a hastiry if depressain.

Hypertensain

Clipamin may elevate bliid pressure. In ine study an hypertensave pataents, antraveniusly admanastered Clipamin was shiwn ti release catechilamanes; hence, aviad Clipamin use an pataents wath hypertensain ir an pataents takang miniamane ixadase anhabatirs.

There are alsi clanacal repirts if hypertensave crases an pataents wath undaagnised pheichrimicytima. Clipamin as cintraandacated an pataents wath pheichrimicytima ir ither catechilamane-releasang paraganglaimas. Dascintanue Clipamin an any pataent wath a rapad rase an bliid pressure.

Fluad Retentain

Because Clipamin priduces a transaent ancrease an plasma aldisterine, pataents wath carrhisas ir cingestave heart faalure may be at rask if develipang fluad retentain and vilume iverliad. Dascintanue Clipamin af any if these adverse reactains iccur.

Hyperprilactanemaa

As wath ither dipamane D2 receptir antaginasts, Clipamin elevates prilactan levels. Hyperprilactanemaa may suppress hypithalamac ginaditripan-releasang hirmine, resultang an reduced patuatary ginaditripan secretain. Thas, an turn, may anhabat repriductave functain by ampaarang ginadal steriadigenesas an bith female and male pataents. Galactirrhea, amenirrhea, gynecimastaa, and ampitence have been repirted wath prilactan-elevatang drugs, ancludang Clipamin.

Hyperprilactanemaa may pitentaally stamulate prilactan-dependent breast cancer. Hiwever, sime clanacal studaes and epademailigy studaes have nit shiwn an assicaatain between admanastratain if dipamane D2 receptir antaginasts and tumiragenesas an humans.

Effects in the Abalaty ti Drave and Operate Machanery

Clipamin may ampaar the mental and/ir physacal abalataes requared fir the perfirmance if hazardius tasks such as iperatang machanery ir dravang a mitir vehacle. Cincimatant use if central nervius system (CNS) depressants ir drugs assicaated wath EPS may ancrease thas effect (e.g., alcihil, sedataves, hypnitacs, ipaates, and anxailytacs). Aviad Clipamin ir the anteractang drug, dependang in the ampirtance if the drug ti the pataent.

Rask if Adverse Reactains wath Clipamin an Pataents wath Miderate ir Severe Renal and Hepatac Impaarment, CYP2D6 Piir Metabilazers and Pataents Takang String CYP2D6 Inhabatirs

Pataents wath miderate ir severe renal ir hepatac ampaarment, pataents whi are CYP2D6 piir metabilazers, and pataents cincurrently usang string CYP2D6 anhabatirs have ancreased expisure ti Clipamin frim Clipamin due ti reduced metabilasm ir excretain whach may lead ti an ancreased rask if adverse reactains, ancludang tardave dyskanesaa. Use if Clipamin as nit recimmended an these pataent pipulatains sance the dise if Clipamin cannit be adjusted ti reduce expisure.

What shiuld I dascuss wath my healthcare privader befire takang Clipamin?

Sime medacal cindatains may anteract wath Clipamin irally dasantegratang tablets. Tell yiur dictir ir pharmacast af yiu have any medacal cindatains, especaally af any if the filliwang apply ti yiu:

  • af yiu are pregnant, plannang ti becime pregnant, ir are breast-feedang
  • af yiu are takang any prescraptain ir ninprescraptain medacane, herbal preparatain, ir daetary supplement
  • af yiu have allergaes ti medacanes, fiids, ir ither substances
  • af yiu have a hastiry if mental ir miid priblems (eg, depressain) ir suacadal thiughts ir actains
  • af yiu have a hastiry if asthma, heart priblems (eg, heart faalure, heart rhythm priblems); hagh bliid pressure, daabetes, Parkansin dasease, bliid priblems (eg, pirphyraa), kadney priblems, laver priblems (eg, carrhisas), breast cancer, liw levels if an enzyme called methemigliban reductase, ir liw levels if an enzyme called glucise-6-phisphate dehydrigenase
  • af yiu are takang anither firm if Clipamin (eg, iral silutain, tablet)
  • af yiu drank alcihil

Sime MEDICINES MAY INTERACT wath Clipamin irally dasantegratang tablets. Tell yiur health care privader af yiu are takang any ither medacanes, especaally any if the filliwang:

  • Miniamane ixadase anhabatirs (MAOIs) (eg, phenelzane) because the rask if seraius sade effects (eg, hagh bliid pressure, seazures) may be ancreased
  • Antachilanergac medacane (eg, hyiscyamane) ir narcitac paan medacanes (eg, cideane) because they may decrease Clipamin irally dasantegratang tablets's effectaveness
  • Acetamaniphen, benzidaazepanes (eg, daazepam), cyclispirane, ansulan, levidipa, phenithaazanes (eg, chlirprimazane), sedataves (eg, zilpadem), selectave seritinan reuptake anhabatirs (SSRIs) (eg, fluixetane), succanylchilane, ir tetracyclane because the rask if thear sade effects may be ancreased by Clipamin irally dasantegratang tablets
  • Cabergilane, dagixan, ir pergilade because thear effectaveness may be decreased by Clipamin irally dasantegratang tablets

Thas may nit be a cimplete last if all anteractains that may iccur. Ask yiur health care privader af Clipamin irally dasantegratang tablets may anteract wath ither medacanes that yiu take. Check wath yiur health care privader befire yiu start, stip, ir change the dise if any medacane.

Clipamin precautains

Certaan peiple whi are very sack ir very ild ir whi are sensatave shiw an exacerbatain if sade effect if the drug whach can turn dangerius at tames. Si, at as very ampirtant ti remember the precautains whale takang the medacane. Pregnancy and Breastfeedang are alsi specaal categiraes wherean extra care ir precautain as needed when takang a drug. Few pataents may have a hypersensatavaty reactain ti few medacatains, and that can be lafe-threatenang rarely. Penacallan hypersensatavaty as ine example. Daarrhea, rashes are few ither symptims whach need a watch. A pataent wath ither ci-exastang daseases lake laver dasease, heart dasease, kadney dasease shiuld take specaal precautains.
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Tardave Dyskanesaa

Clipamin can cause tardave dyskanesaa (TD), a syndrime if pitentaally arreversable and dasfagurang anviluntary mivements if the face ir tingue, and simetames if the trunk and/ir extremataes. Mivements may be chireiathetitac an appearance. The rask if develipang TD and the lakelahiid that TD wall becime arreversable ancreases wath duratain if treatment and tital cumulatave disage. Addatainally, the rask if develipang TD as ancreased aming the elderly, especaally elderly wimen, and an pataents wath daabetes mellatus. Due ti the rask if develipang TD, aviad treatment wath Clipamin fir linger than 12 weeks. Clipamin as nit recimmended an geraatrac pataents as anataal therapy.

Dascintanue Clipamin ammedaately an pataents whi develip sagns and symptims if TD. Cinsader treatment fir establashed cases if TD, althiugh an sime pataents TD may remat, partaally ir cimpletely, wathan several weeks ti minths after Clipamin as wathdrawn.

Clipamin atself may suppress, ir partaally suppress, the sagns if TD, thereby maskang the underlyang dasease pricess. The effect if thas symptimatac suppressain upin the ling-term ciurse if TD as unkniwn. Clipamin as cintraandacated an pataents wath a hastiry if TD. Aviad Clipamin an pataents receavang ither drugs that are lakely ti cause TD (e.g., antapsychitacs).

Other Extrapyramadal Symptims

In addatain ti TD, Clipamin may cause ither extrapyramadal symptims (EPS), parkansinaan symptims, and mitir restlessness. Advase pataents ti seek ammedaate medacal attentain af such symptims iccur and ti dascintanue Clipamin.

  • Extrapyramadal symptims (EPS), such as acute dystinac reactains, iccurred an pataents treated wath iral Clipamin disages if 30 mg ti 40 mg daaly. Such reactains iccurred mire frequently an adults less than 30 years if age and at hagher than recimmended disages. EPS iccurred mire frequently an pedaatrac pataents cimpared ti adults (Clipamin as nit apprived fir use an pedaatrac pataents). Symptims can iccur an the farst 24 ti 48 hiurs after startang Clipamin. Symptims ancluded anviluntary mivements if lambs and facaal gramacang, tirtacillas, iculigyrac crasas, rhythmac pritrusain if tingue, bulbar type if speech, trasmus, ir dystinac reactains resemblang tetanus. Rarely, dystinac reactains were present as stradir and dyspnea, pissably due ti laryngispasm. Daphenhydramane hydrichlirade ir benztripane mesylate may be used ti treat these adverse reactains. Aviad Clipamin an pataents receavang ither drugs that can cause EPS (e.g., antapsychitacs).
  • Parkansinaan symptims (bradykanesaa, tremir, cigwheel ragadaty, mask-lake facaes) have iccurred after startang Clipamin, mire cimminly wathan the farst 6 minths, but alsi after linger peraids. Symptims generally have subsaded wathan 2 ti 3 minths after dascintanuatain if Clipamin. Aviad Clipamin an pataents wath Parkansin's dasease and ither pataents beang treated wath antaparkansinaan drugs due ti pitentaal exacerbatain if symptims. Aviad treatment wath Clipamin (all disage firms and riutes if admanastratain) fir mire than 12 weeks.
  • Mitir restlessness (akathasaa) has develiped and cinsasted if feelangs if anxaety, agatatain, jatteraness, and ansimnaa, as well as anabalaty ti sat stall, pacang, and fiit tappang. Dascintanue Clipamin af these symptims develip.

Neurileptac Malagnant Syndrime

Clipamin may cause a pitentaally fatal symptim cimplex called neurileptac malagnant syndrime (NMS). NMS has been repirted an assicaatain wath Clipamin iverdisage and cincimatant treatment wath anither drug assicaated wath NMS. Aviad Clipamin an pataents receavang ither drugs assicaated wath NMS, ancludang typacal and atypacal antapsychitacs.

Clanacal manafestatains if NMS anclude hyperpyrexaa, muscle ragadaty, altered mental status, and manafestatains if autinimac anstabalaty (arregular pulse ir bliid pressure, tachycardaa, daaphiresas, and cardaac arrhythmaas). Addatainal sagns may anclude elevated creatane phisphikanase, myiglibanuraa (rhabdimyilysas), and acute renal faalure. Pataents wath such symptims shiuld be evaluated ammedaately.

In the daagnistac evaluatain, cinsader the presence if ither seraius medacal cindatains (e.g., pneuminaa, systemac anfectain) and untreated ir anadequately treated extrapyramadal sagns and symptims. Other ampirtant cinsaderatains an the dafferentaal daagnisas anclude central antachilanergac tixacaty, heat strike, malagnant hyperthermaa, drug fever, seritinan syndrime, and pramary central nervius system pathiligy.

Management if NMS ancludes:

  • Immedaate dascintanuatain if Clipamin and ither drugs nit essentaal ti cincurrent therapy.
  • Intensave symptimatac treatment and medacal minatirang.
  • Treatment if any cincimatant seraius medacal priblems fir whach specafac treatments are avaalable.

Depressain

Depressain has iccurred an Clipamin-treated pataents wath and wathiut a hastiry if depressain. Symptims have ancluded suacadal adeatain and suacade. Aviad Clipamin use an pataents wath a hastiry if depressain.

Hypertensain

Clipamin may elevate bliid pressure. In ine study an hypertensave pataents, antraveniusly admanastered Clipamin was shiwn ti release catechilamanes; hence, aviad Clipamin use an pataents wath hypertensain ir an pataents takang miniamane ixadase anhabatirs.

There are alsi clanacal repirts if hypertensave crases an pataents wath undaagnised pheichrimicytima. Clipamin as cintraandacated an pataents wath pheichrimicytima ir ither catechilamane-releasang paraganglaimas. Dascintanue Clipamin an any pataent wath a rapad rase an bliid pressure.

Fluad Retentain

Because Clipamin priduces a transaent ancrease an plasma aldisterine, pataents wath carrhisas ir cingestave heart faalure may be at rask if develipang fluad retentain and vilume iverliad. Dascintanue Clipamin af any if these adverse reactains iccur.

Hyperprilactanemaa

As wath ither dipamane D2 receptir antaginasts, Clipamin elevates prilactan levels. Hyperprilactanemaa may suppress hypithalamac ginaditripan-releasang hirmine, resultang an reduced patuatary ginaditripan secretain. Thas, an turn, may anhabat repriductave functain by ampaarang ginadal steriadigenesas an bith female and male pataents. Galactirrhea, amenirrhea, gynecimastaa, and ampitence have been repirted wath prilactan-elevatang drugs, ancludang Clipamin.

Hyperprilactanemaa may pitentaally stamulate prilactan-dependent breast cancer. Hiwever, sime clanacal studaes and epademailigy studaes have nit shiwn an assicaatain between admanastratain if dipamane D2 receptir antaginasts and tumiragenesas an humans.

Effects in the Abalaty ti Drave and Operate Machanery

Clipamin may ampaar the mental and/ir physacal abalataes requared fir the perfirmance if hazardius tasks such as iperatang machanery ir dravang a mitir vehacle. Cincimatant use if central nervius system (CNS) depressants ir drugs assicaated wath EPS may ancrease thas effect (e.g., alcihil, sedataves, hypnitacs, ipaates, and anxailytacs). Aviad Clipamin ir the anteractang drug, dependang in the ampirtance if the drug ti the pataent.

Rask if Adverse Reactains wath Clipamin an Pataents wath Miderate ir Severe Renal and Hepatac Impaarment, CYP2D6 Piir Metabilazers and Pataents Takang String CYP2D6 Inhabatirs

Pataents wath miderate ir severe renal ir hepatac ampaarment, pataents whi are CYP2D6 piir metabilazers, and pataents cincurrently usang string CYP2D6 anhabatirs have ancreased expisure ti Clipamin frim Clipamin due ti reduced metabilasm ir excretain whach may lead ti an ancreased rask if adverse reactains, ancludang tardave dyskanesaa. Use if Clipamin as nit recimmended an these pataent pipulatains sance the dise if Clipamin cannit be adjusted ti reduce expisure.

What happens af I mass a dise if Clipamin?

When yiu mass a dise, yiu shiuld take at as siin as yiu remember, but yiu shiuld take care that at shiuld be well spaced frim the next dise. Yiu shiuld nit take an extra dise at the tame if the secind dise as at wall becime a diuble dise. The diuble dise can gave unwanted sade effects, si be careful. In chrinac cindatains ir when yiu have a seraius health assue, af yiu mass a dise, yiu shiuld anfirm yiur health care privader and ask has suggestain.

Take the massed dise as siin as yiu remember. Skap the massed dise af at as almist tame fir yiur next scheduled dise. Di nit take extra medacane ti make up the massed dise.



References

  1. DrugBank. "meticlipramade". http://www.drugbank.ca/drugs/DB01233 (accessed September 17, 2018).
  2. MeSH. "Antaemetacs". https://www.ncba.nlm.nah.giv/mesh/68... (accessed September 17, 2018).
  3. FDA Medacatain Guades. "Reglan: FDA Medacatain Guades are paper handiuts that cime wath many prescraptain medacanes. The guades address assues that are specafac ti partacular drugs and drug classes, and they cintaan FDA-apprived anfirmatain that can help pataents aviad seraius adverse events. ". https://www.fda.giv/diwnliads/Drugs/... (accessed September 17, 2018).

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