What happens if I overdose Clorketam 1000?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe shallow or slowed breathing.
Proper storage of Clorketam 1000:
Clorketam 1000 is usually handled and stored by a health care provider. Keep Clorketam 1000 out of the reach of children and away from pets.
Overdose of Clorketam 1000 in details
Respiratory depression can result from an overdosage of Clorketam 1000 HCl. Supportive ventilation should be employed. Mechanical support of respiration that will maintain adequate blood oxygen saturation and carbon dioxide elimination is preferred to administration of analeptics.
Clorketam 1000 has a wide margin of safety; several instances of unintentional administration of overdoses of Clorketam 1000 (up to 10 times that usually required) have been followed by prolonged but complete recovery.
What should I avoid while taking Clorketam 1000?
This medication may impair your thinking or reactions. You will probably not be allowed to drive yourself home after your surgery or medical procedure. Avoid driving or operating machinery for at least 24 hours after you have received Clorketam 1000.
Follow your doctor's instructions about any restrictions on food, beverages, or activity after you recover from anesthesia.
Clorketam 1000 warnings
Cardiac function should be continually monitored during the procedure in patients found to have hypertension or cardiac decompensation.
Postoperative confusional states may occur during the recovery period.
Respiratory depression may occur with overdosage or too rapid a rate of administration of Clorketam 1000 hydrochloride, in which case supportive ventilation should be employed. Mechanical support of respiration is preferred to administration of analeptics.
What should I discuss with my healthcare provider before taking Clorketam 1000?
You should not receive Clorketam 1000 if you are allergic to it, or if you have untreated or uncontrolled hypertension (high blood pressure).
Do not use Clorketam 1000 if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
To make sure Clorketam 1000 is safe for you, tell your doctor if you have:
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heart disease;
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high blood pressure;
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a history of alcoholism; or
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if you recently drank large amounts of alcohol.
Clorketam 1000 may be habit forming and should be used only by the person for whom it was prescribed.
Clorketam 1000 may be harmful to an unborn baby. Before you receive Clorketam 1000, tell your doctor if you are pregnant.
It is not known whether Clorketam 1000 passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Clorketam 1000 precautions
General
Clorketam 1000 hydrochloride injection should be used by or under the direction of physicians experienced in administering general anesthetics and in maintenance of an airway and in the control of respiration.
Because pharyngeal and laryngeal reflexes are usually active, Clorketam 1000 hydrochloride should not be used alone in surgery or diagnostic procedures of the pharynx, larynx, or bronchial tree. Mechanical stimulation of the pharynx should be avoided, whenever possible, if Clorketam 1000 hydrochloride is used alone. Muscle relaxants, with proper attention to respiration, may be required in both of these instances.
Resuscitative equipment should be ready for use.
The incidence of emergence reactions may be reduced if verbal and tactile stimulation of the patient is minimized during the recovery period. This does not preclude the monitoring of vital signs.
The intravenous dose should be administered over a period of 60 seconds. More rapid administration may result in respiratory depression or apnea and enhanced pressor response.
In surgical procedures involving visceral pain pathways, Clorketam 1000 hydrochloride should be supplemented with an agent which obtunds visceral pain.
Use with caution in the chronic alcoholic and the acutely alcohol-intoxicated patient.
An increase in cerebrospinal fluid pressure has been reported following administration of Clorketam 1000 hydrochloride. Use with extreme caution in patients with preanesthetic elevated cerebrospinal fluid pressure.
Usage In Pregnancy
Since the safe use in pregnancy, including obstetrics (either vaginal or abdominal delivery), has not been established, such use is not recommended.
Geriatric Use
Clinical studies of Clorketam 1000 hydrochloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Pediatric Use
Safety and effectiveness in pediatric patients below the age of 16 have not been established.
What happens if I miss a dose of Clorketam 1000?
Since Clorketam 1000 is usually given for anesthesia, you are not likely to be on a dosing schedule.
References
- DrugBank. "ketamine". http://www.drugbank.ca/drugs/DB01221 (accessed September 17, 2018).
- MeSH. "Analgesics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
