Clorpropamida Dosage

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How do you administer this medicine?

Dosage of Clorpropamida in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Clorpropamida Dosage

Applies to the following strength(s): 30 mg/mL; 100 mg/mL; 25 mg/mL; 30 mg; 75 mg; 150 mg; 25 mg; 100 mg; 10 mg/5 mL; 10 mg; 50 mg; 200 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

  • Psychosis
  • Mania
  • Nausea/Vomiting
  • Light Sedation
  • Hiccups
  • Porphyria
  • Tetanus

Usual Pediatric Dose for:

  • Opiate Withdrawal
  • Schizophrenia
  • Nausea/Vomiting

Additional dosage information:

  • Renal Dose Adjustments
  • Liver Dose Adjustments
  • Dose Adjustments
  • Precautions
  • Dialysis
  • Other Comments

Usual Adult Dose for Psychosis

IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.

Oral: Initial Dose: 10 to 25 mg orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.

Usual Maintenance Dose: 200 mg/day orally

Some patients require higher dosages (e.g., 800 mg daily is not uncommon in discharged mental patients). Increase dosage gradually until symptoms are controlled. Maximum improvement may not be seen for weeks or even months. Continue optimum dosage for 2 weeks, then gradually reduce dosage to the lowest effective maintenance level.

Usual Adult Dose for Mania

Oral: 10 mg orally 3 to 4 times a day or 25 mg orally 2 to 3 times a day.

More severe cases: 25 mg orally 3 times a day.

After 1 to 2 days, dose may be increased by 20 to 50 mg/day at semiweekly intervals.

Prompt control of severe symptoms: 25 mg IM one time.

If necessary, repeat in 1 hour. Subsequent doses should be oral, 25 to 50 mg three times a day.

IM: 25 mg injection one time. If necessary, may give additional 25 to 50 mg injection in 1 hour.

Increase subsequent doses gradually over several days up to 400 mg every 4 to 6 hours in exceptionally severe cases.

Usually patient becomes quiet and cooperative within 24 to 48 hours and oral doses may be substituted.

Oral: 500 mg/day is generally sufficient. Gradual increases to 2000 mg/day or more may be necessary.

There is usually little therapeutic gain to be achieved by exceeding 1000 mg/day for extended periods.

Less acutely disturbed

Oral: 25 mg three times a day.

May increase gradually until effective dose is reached, usually 400 mg/day.

Usual Adult Dose for Nausea/Vomiting

Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary.

IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.

Rectal: One 100 mg suppository every 6 to 8 hours as needed. In some patients, half this dose will do.

Nausea/Vomiting During Surgery:

IM: 12.5 mg one time. May repeat in 30 minutes if necessary and if no hypotension occurs.

IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1 mg/mL.

Usual Adult Dose for Light Sedation

For light sedation prior to a medical or surgical procedure:

Oral: 25 to 50 mg, 2 to 3 hours before the operation.

IM: 12.5 to 25 mg, 1 to 2 hours before operation.

Usual Adult Dose for Hiccups

Oral: 25 to 50 mg 3 to 4 times a day.

IM: If symptoms persist for 2 to 3 days, give 25 to 50 mg IM.

IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50 mg in 500 to 1000 mL of saline.

Usual Adult Dose for Porphyria

Oral: 25 to 50 mg 3 to 4 times a day.

Can usually be discontinued after several weeks, but maintenance therapy may be necessary for some patients.

IM: 25 mg injection 3 to 4 times a day until patient can take oral therapy.

Usual Adult Dose for Tetanus

IM: 25 to 50 mg given 3 to 4 times daily, usually in conjunction with barbiturates. Total doses and frequency of administration must be determined by the patient's response, starting with low doses and increasing gradually.

IV: 25 to 50 mg diluted to at least 1 mg/mL and administered at a rate of 1 mg/min.

Usual Pediatric Dose for Opiate Withdrawal

less than 1 month:

Neonatal abstinence syndrome (withdrawal from maternal opioid use; controls CNS and gastrointestinal symptoms):

Intramuscular: Initial: 0.55 mg/kg/dose given every 6 hours; change to oral after approximately 4 days, decrease dose gradually over 2 to 3 weeks. Note: Clorpropamida is rarely used for neonatal abstinence syndrome due to adverse effects such as hypothermia, cerebellar dysfunction, decreased seizure threshold, and eosinophilia; other agents are preferred.

Usual Pediatric Dose for Schizophrenia

6 months and older:

Oral: 0.5 to 1 mg/kg/dose orally every 4 to 6 hours; older children may require 200 mg/day or higher

intramuscular or intravenous: 0.5 to 1 mg/kg/dose every 6 to 8 hours

Maximum recommended doses:

less than 5 years (less than 22.7 kg): 40 mg/day

5 years and older: (22.7 to 45.5 kg): 75 mg/day

Usual Pediatric Dose for Nausea/Vomiting

Nausea and vomiting:

Oral: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed

intramuscular or intravenous: 0.5 to 1 mg/kg/dose every 6 to 8 hours;

Maximum recommended doses:

less than 5 years (less than 22.7 kg): 40 mg/day

5 and older (22.7-45.5 kg): 75 mg/day

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Adjust dosage to individual and the severity of condition, recognizing that the mg for mg potency relationship among all dosage forms has not been precisely established clinically. It is important to increase dosage until symptoms are controlled. Dosage should be increased more gradually in debilitated or emaciated patients. In continued therapy, gradually reduce dosage to the lowest effective maintenance level, after symptoms have been controlled for a reasonable period.

In general, dosage recommendations for other oral forms of the drug may be applied to the sustained release capsules on the basis of total daily dosage in milligrams.

The 100 mg and 200 mg tablets are for use in severe neuropsychiatric conditions.

Precautions

In general, dosage levels should be lower in the elderly, the emaciated and the debilitated. Clorpropamida should be used cautiously in patients with cardiovascular, liver or renal disease.

Dialysis

Data not available

Other Comments

Clorpropamida should generally not be used in children under 6 months of age except where potentially lifesaving.

More about Clorpropamida

  • Side Effects
  • During Pregnancy or Breastfeeding
  • Dosage Information
  • Drug Images
  • Drug Interactions
  • Support Group
  • En Espanol
  • 30 Reviews - Add your own review/rating

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Related treatment guides

  • Light Sedation
  • Opiate Withdrawal
  • Hiccups
  • Nausea/Vomiting
  • Mania
  • More (4) »

What other drugs will affect Clorpropamida?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can interact with Clorpropamida and cause medical problems or increase side effects. Tell your doctor if you regularly use any of these medicines, or any other anti-psychotic medications.

Tell your doctor about all other medicines you use, especially:

  • atropine (Atreza, Sal-Tropine);
  • lithium (Eskalith, Lithobid);
  • phenytoin (Dilantin);
  • an antibiotic;
  • birth control pills or hormone replacement estrogens;
  • blood pressure medication;
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • certain asthma medications or bronchodilators;
  • incontinence medications;
  • insulin or diabetes medications you take by mouth;
  • medication for nausea, vomiting, or motion sickness;
  • medications to treat or prevent malaria;
  • medications used for general anesthesia;
  • medicines used to prevent organ transplant rejection;
  • numbing medicine such as lidocaine or Novocain;
  • a stimulant or ADHD medication;
  • ulcer or irritable bowel medications; or
  • medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma).

This list is not complete and there are many other medicines that can interact with Clorpropamida. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Clorpropamida interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Clorpropamida, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Alcohol, barbiturates and other sedatives may intensify the CNS depressant effects of Clorpropamida and respiratory depression may occur.

The hypotensive effect of most antihypertensive agents, especially alpha-adrenoceptor blocking agents, may be exaggerated by Clorpropamida.

Clorpropamida has mild anticholinergic activity which may be enhanced by other anticholinergic drugs.

Anticholinergic drugs may decrease the antipsychotic effect of Clorpropamida. Clorpropamida may oppose the action of some drugs, including amphetamine, levodopa, adrenaline, clonidine and guanethidine.

Some drugs interfere with the absorption of neuroleptic agents, e.g. antacids, lithium, anti-Parkinsonian agents. Although increases or decreases have been observed in the plasma concentrations of a number of drugs, including propranolol and phenobarbitone, these were not of clinical significance.

At high dosage, Clorpropamida reduces the response to hypoglycaemic agents, which may require an increase in dosage of the latter.

Clinically significant adverse drug interactions with alcohol, guanethidine and hypoglycaemic agents are documented. Adrenaline must not be used in cases of overdosage with Clorpropamida. Other interactions are of theoretical interest and are not of a serious nature. Concomitant administration of desferrioxamine and prochlorperazine has been reported to cause a transient metabolic encephalopathy with loss of consciousness for 48 to 72 hours. The possibility of a similar occurrence with Clorpropamida exists, because it shares many of the pharmacological activities of prochlorperazine.


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References

  1. DailyMed. "CHLORPROPAMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "CHLORPROMAZINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. FDA/SPL Indexing Data. "WTM2C3IL2X: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Clorpropamida are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Clorpropamida. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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