Actions of Cogintol in details
Description: Cogintol is a centrally-acting anticholinergic agent w/ antihistamine activity. It decreases imbalance between the neurotransmitters acetylcholine and dopamine by antagonising the effect of acetylcholine, thus improving the symptoms of early Parkinson's disease.
Onset: W/in a few min (IM/IV); w/in 1 hr (oral).
Pharmacokinetics:
Absorption: Absorbed from the GI tract. Time to peak plasma concentration: 7 hr (oral).
Distribution:
Oral: It crosses the blood brain barrier and placenta. Plasma protein binding: Approx 95%.
Excretion:
Oral: Via faeces (small amount as unchanged drug).
Cogintol pharmacology
Cogintol is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Cogintol partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
Reviews
The results of a survey conducted on ndrugs.com for Cogintol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cogintol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
