Actions of Colofac/Colofac Retard in details
Pharmacotherapeutic Group: Synthetic musculotropic antispasmodic with no anticholinergic activity, esters with tertiary amino group.
Pharmacology: Pharmacodynamics: Musculotropic antispasmodic with a direct action on the smooth muscle of the gastrointestinal tract, relieving spasm without affecting normal gut motility. Since this action is not mediated by the autonomic nervous system, the usual anticholinergic side effects are absent.
Colofac/Colofac Retard Retard is suitable for patients with prostatic hypertrophy and glaucoma.
Clinical Efficacy and Safety: Colofac/Colofac Retard: The clinical efficacy and safety of different formulations of mebeverine were evaluated in >1500 patients. Considerable improvements in the predominant symptoms of irritable bowel syndrome (eg, abdominal pain, stool characteristics) were generally observed in reference or baseline-controlled clinical studies.
All formulations of mebeverine were generally safe and well tolerated in the recommended dose regimen.
Pharmacokinetics: The prolonged-release formulation permits a twice daily dosing scheme.
Colofac/Colofac Retard: Absorption: Mebeverine is rapidly and completely absorbed after oral administration of tablets.
Distribution: No significant accumulation occurs after multiple doses.
Biotransformation: Mebeverine hydrochloride is mainly metabolized by esterases, which initially split the ester bonds into veratric acid and mebeverine alcohol.
The main metabolite in plasma is demethylated carboxylic acid (DMAC). The steady state elimination half-life of DMAC is 2.45 hrs. During multiple dosing, the peak plasma concentration (Cmax) of DMAC for the coated tablets with 135 mg is 1670 ng/mL and time to reach the peak plasma concentration (tmax) is 1 hr.
Colofac/Colofac Retard/Colofac/Colofac Retard Retard: Elimination: Mebeverine is not excreted as such, but metabolized completely; the metabolites are excreted nearly completely. Veratric acid is excreted into the urine, mebeverine alcohol is also excreted into the urine, partly as the corresponding carboxylic acid (MAC) and partly as the DMAC.
Colofac/Colofac Retard pharmacology
The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
- EPA DSStox. "Mebeverine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
ReviewsThe results of a survey conducted on ndrugs.com for Colofac/Colofac Retard are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Colofac/Colofac Retard. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
1 consumer reported administrationWhen best can I take Colofac/Colofac Retard, on an empty stomach, before or after food?
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Information checked by Dr. Sachin Kumar, MD Pharmacology