Colospa Actions

Rating: 3.3 - 6 review(s)
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Actions of Colospa in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Pharmacotherapeutic Group: Synthetic anticholinergics, esters with tertiary amino group. ATC Code: A03AA04.

Pharmacology: Pharmacodynamics: Mechanism of Action and Pharmacodynamic Effects: Colospa is a musculotropic antispasmodic with a direct effect on the smooth muscle of the gastrointestinal tract, relieving spasm without affecting normal gut motility. Since this effect is not mediated by the autonomic nervous system, the typical anticholinergic side effects are absent.

Pharmacokinetics: Absorption: Colospa is rapidly and completely absorbed after oral administration. The modified-release formulation permits a twice-daily dosing scheme.

Distribution: No significant accumulation occurs after multiple doses.

Biotransformation: Colospa is mainly metabolized by esterases, which split the ester bonds into veratric acid and Colospa alcohol firstly.

In plasma, demethylated carboxylic acid (DMAC) is the main metabolite. The steady-state elimination half-life t½ of DMAC is approximately 5.77 hrs. During multiple dosing (200 mg twice daily) the maximum plasma concentration (Cmax) of DMAC is 804 ng/mL and time to maximum plasma concentration (tmax) is about 3 hrs. The relative bioavailability appears to be optimal with a mean ratio of 97%.

Elimination: Colospa is not excreted as such, but metabolized completely; the metabolites are excreted nearly completely. Veratric acid is excreted into the urine, Colospa alcohol is also excreted into the urine, partly as the corresponding carboxylic acid (MAC) and partly as DMAC.

Paediatric Population: No pharmacokinetic studies have been conducted in children with any formulation of Colospa.

Colospa pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
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The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.

References

  1. DailyMed. "AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Chlordiazepoxide: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. EPA DSStox. "Mebeverine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Colospa are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Colospa. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

4 consumers reported administration

When best can I take Colospa, on an empty stomach, before or after food?
ndrugs.com website users have also released a report stating that Colospa should be taken Before food. In any case, this may not be the right description on how you ought to take this Colospa. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Colospa can be taken.
Users%
Before food2
50.0%
Empty stomach1
25.0%
After food1
25.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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