Irritable bowel syndrome & allied conditions eg, chronic irritable colon, spastic constipation, mucous colitis and spastic colitis. Symptomatic treatment of abdominal pain, cramps, nonspecific diarrhoea & flatulence. GI spasm secondary to organic diseases eg, diverticulitis, gastritis, duodenitis, oesophagitis, cholecystitis, Crohn's disease, ulcerative colitis, peptic ulcer, gallbladder disease, hiatus hernia, GIT inflammation.
Colospasmin is used to treat irritable bowel syndrome (disorder of the intestines that leads to cramps in the abdomen, gas, bloating and changes in bowel habits). It is also used to treat other conditions that involve spasm and pain related to small and large bowel.
Each capsule contains Mebeverine 200 mg.
Colospasmin also contains the following excipients: Capsule Content (Granules): Magnesium stearate, polyacrylate dispersion 30%, talc, hypromellose, methacrylic acid-ethyl acrylate copolymer (1:1) dispersion 30% and glycerol triacetate. Capsule Shell: Gelatin, titanium dioxide (E171). Printing Ink: Shellac (E904), black iron oxide (E172), propylene glycol, concentrated ammonia solution, potassium hydroxide.
Adults: 1 capsule twice daily (1 in the morning and 1 in the evening).
Special Populations: Elderly, Renal and Hepatic Impairment: No posology studies in elderly, renal and/or hepatically impaired patients have been performed. However, no specific risk for elderly, renal and/or hepatically impaired patients could be identified from available post-marketing data. No dosage adjustment is deemed necessary in these patients.
Missed Dose: In case of ≥1 doses missed, continue with the next dose as prescribed; the missed doses are not to be taken in addition to the regular dose.
Administration: The capsules should be swallowed with a sufficient amount of water (at least 100 mL of water).
It should not be chewed because the coating is intended to ensure a prolonged release mechanism.
No interaction studies have been performed except with alcohol. In vitro and in vivo studies in animals have demonstrated the absence of any interaction between Colospasmin and ethanol.
Incompatibilities: Not applicable.
Although adverse effects appear rare, gastrointestinal disturbances, dizziness, headache, insomnia, anorexia and tachycardia have been reported in patients receiving Colospasmin.
Hypersensitivity to Colospasmin or to any of the excipients of Colospasmin.
Mebeverine in Bahrain, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Romania, Saudi Arabia, Sudan, United Arab Emirates, Yemen.
List of Colospasmin substitutes (brand and generic names)
|Sort by popularity|
|Unit description / dosage (Manufacturer)||Price, USD|
|Colospas FC tab 135 mg 30's (Nabiqasim)|
|Colospasmin Forte (Egypt)|
|Tablet; Oral; Mebeverine Hydrochloride 135 mcg (Agis)|
|Colotal 135mg (Israel)|
|Coloverin SR (Egypt)|
|DESPAS 10 MG/250 MG TABLET 1 strip / 10 tablets each (Dew Drops Lab)||$ 0.40|
|Dobecon 100 mg x 10 x 10's|
|Dobecon 100 mg x 1000's|
|Tablet, Prolonged Release; Oral; Mebeverine Hydrochloride 200 mg (Saval)|
|Duskonal Retard (Georgia)|
|Duspamen (Bahrain, Oman)|
|Duspatal (Chile, Germany, Italy, Netherlands, Portugal)|
|Capsule; Oral; Mebeverine Hydrochloride 200 mg (Grunenthal)|
|Dragee; Oral; Mebeverine Hydrochloride 135 mg (Grunenthal)|
|Tablet, Film-Coated; Oral; Mebeverine Hydrochloride 100 mg (Grunenthal)|
|Duspatal Retard (Chile, Portugal)|
|Capsule, Retard; Oral; Mebeverine Hydrochloride 200 mg|
|Duspatalin (Argentina, Bahrain, Bangladesh, Belgium, Brazil, Bulgaria, Colombia, Czech Republic, Denmark, Estonia, France, Georgia, Greece, Hong Kong, Hungary, Indonesia, Latvia, Lithuania, Luxembourg, Malaysia, Mexico, Myanmar, Oman, Peru, Philippines, Poland, Romania, Russian Federation, Singapore, Slovakia, Spain, Sri Lanka, Switzerland, Taiwan, Tunisia, Turkey, Venezuela)|
|Capsule, Prolonged Release; Oral; Mebeverine Hydrochloride 200 mg (Abbott Products)|
|Tablet, Film-Coated; Oral; Mebeverine Hydrochloride 100 mg (Abbott Products)|
|Duspatalin 200mg - 30 Capsule (Abbott Products)||$ 26.00|
|Duspatalin 135 mg x 1's (Abbott Products)|
|Duspatalin 135 mg x 5 Blister x 10 Tablet (Abbott Products)|
|Duspatalin 135 mg x 50's (Abbott Products)||$ 10.20|
|Duspatalin 200 mg x 30's (Abbott Products)|
|Duspatalin 100 mg x 50's (Abbott Products)|
|Duspatalin 100 mg x 100's (Abbott Products)||$ 32.49|
|Duspatalin coated tab 135 mg 50's (Abbott Products)|
|Duspatalin 135mg (Bulgaria)|
|Duspatalin 200 mg retard (Hungary)|
|Duspatalin 200mg (Bulgaria)|
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Information checked by Dr. Sachin Kumar, MD Pharmacology