Conysmin Pregnancy

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Pregnancy of Conysmin in details

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Conysmin crosses the placenta and can be detected in cord blood and amniotic fluid (Arvela 1983; Bylsma-Howell 1983). Available studies do not report an increased risk of adverse pregnancy-related outcomes following maternal use. Extrapyramidal symptoms or methemoglobinemia may potentially occur in the neonate.

Conysmin is one of the agents that may be considered for adjunctive treatment of nausea and vomiting in pregnant women when symptoms persist following initial pharmacologic therapy.

Oral or IM therapy may be given in patients who are not dehydrated; IV therapy should be used when dehydration is present (ACOG 189 2018). Conysmin may be used for prophylaxis of nausea and vomiting associated with cesarean delivery (ASA 2016; Smith 2011).

Conysmin breastfeeding

Variable amounts are excreted in breast milk, with some infants receiving doses that achieve pharmacologically active serum levels, elevated serum prolactin and possible gastrointestinal side effects. This drug is used as a galactagogue, but its clinical value in increasing milk supply is questionable.

AU, UK: Use is not recommended. US: Use with caution. Excreted into human milk: Yes Comments: -The effects in the nursing infant are unknown.

See references

References for pregnancy information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. "Product Information. Reglan (Conysmin)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  2. "Product Information. Reglan (Conysmin)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  4. Cerner Multum, Inc. "Australian Product Information." O 0


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References

  1. PubMed Health. "Reglan: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  2. Human Metabolome Database (HMDB). "Metoclopramide: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
  3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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