Cotrimoxazole Uses

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Cotrimoxazole indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Infectious-inflammatory diseases caused by sensitive to Cotrimoxazole microorganisms: respiratory tract infections (including acute and chronic bronchitis, empyema, bronchiectasis, lung abscess, pneumonia, tonsillitis, pharyngitis); urinary tract infections (including gonococcal urethritis), cystitis, pyelonephritis, prostatitis; gastrointestinal infections (including enteritis, typhoid, paratyphoid, dysentery, cholecystitis, cholangitis); infections of skin and soft tissue (including pyoderma, furunculosis, wound infection), septicemia, brucellosis.

Cotrimoxazole description

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. trimethoprim resistance has been reported.

Cotrimoxazole dosage

Individual. Doses of Cotrimoxazole Lafayette Pharmaceutical Laboratory are given on the basis of sulfamethoxazole. For oral administration for adults and children older than 12 years the average dose is 0.4-2 g every 12 hours (2 times / day), course of treatment - 5-14 days.

Orally for children aged 2-5 months - 100 mg 2 times / day; 1-2 years - 100 mg 2 times / day; 3-6 years - 200 mg 2 times / day; 6-12 years at 200-400 mg 2 times / day.

Parenterally administered only in the absence of the possibility of oral administration. IM for adults and children over 12 years - 800 mg every 12 hours; for children aged 6-12 years - 30 mg / kg / day, interval between each dose - 12 hours.

If necessary prescribed IV as drops at 0.8-1.6 g every 12 hours (2 times / day) within 5 days. For children aged 6-12 years are prescribed at 15 mg / kg every 12 hours. Average duration of Cotrimoxazole Lafayette Pharmaceutical Laboratory injection - 30-60 minutes but no more than 1.5 hours. The course of treatment is average 5 days, then if necessary go to oral administration. The maximum oral daily dose for adults is 3.6 g.

Cotrimoxazole interactions

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With the simultaneous application of Cotrimoxazole effect of anticoagulants of indirect action is greatly enhanced due to slow inactivation of the latter, as well as their release from binding with plasma proteins.

In an application with some sulfonylureas may increase hypoglycemic effect which is associated with an increased concentration of free fraction of Cotrimoxazole.

The simultaneous use of Cotrimoxazole and methotrexate may increase the toxicity of the latter (in particular to the appearance of pancytopenia) due to its release from binding to plasma proteins.

Influenced butadion, indomethacin, naproxen, salicylates and other NSAIDs may increase the action Cotrimoxazole with the development of undesirable effects, since there release of active substances from binding with blood proteins and increase their concentration.

Simultaneous treatment with diuretics and Cotrimoxazole increases the risk of thrombocytopenia caused by the latter especially in elderly patients.

In the case of co-administration chloridine with Cotrimoxazole Lafayette Pharmaceutical Laboratory antimicrobial effect is enhanced because chloridine inhibits the formation of tetrahydrofolic acid required for the synthesis of nucleic acids and proteins. In turn sulfonamides inhibit the formation of dihydrofolic acid, a precursor of tetrahydrofolic acid. This combination is widely used in the treatment of toxoplasmosis.

Absorption of sulfamethoxazole and trimethoprim at their joint reception with cholestyramine decreases the formation of insoluble complexes, which leads to a decrease in their concentration in the blood.

Cotrimoxazole side effects

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CNS

Apathy, aseptic meningitis, ataxia, convulsions, depression, fatigue, hallucinations, headache, insomnia, nervousness, peripheral neuritis, vertigo, weakness.

EENT

Tinnitus.

Endocrine

Diuresis, hypoglycemia.

Hematologic

Agranulocytosis, aplastic anemia, eosinophilia, hemolytic anemia, hypoprothrombinemia, leukopenia, megaloblastic anemia, methemoglobinemia, neutropenia, thrombocytopenia.

Hypersensitivity

Allergic myocarditis, anaphylaxis, angioedema, chills, conjunctival and scleral injection, drug fever, erythema multiforme, exfoliative dermatitis, generalized allergic reactions, generalized skin eruptions, Henoch-Schoenlein purpura, periarteritis nodosa, photosensitivity, pruritus, rash, serum sickness–like syndrome, Stevens-Johnson syndrome, systemic lupus erythematosus, toxic epidermal necrolysis, urticaria.

GI

Abdominal pain, anorexia, diarrhea, elevation of serum transaminase and bilirubin, emesis, glossitis, hepatitis (including cholestatic jaundice and hepatic necrosis), nausea, pancreatitis, pseudomembranous enterocolitis, stomatitis, vomiting.

Genitourinary

BUN and serum creatinine elevation, crystalluria and nephrotoxicity in association with cyclosporine, interstitial nephritis, renal failure, toxic nephrosis with oliguria and anuria.

Metabolic

Hyperkalemia.

Musculoskeletal

Arthralgia, myalgia, rhabdomyolysis.

Respiratory

Cough, pulmonary infiltrates, shortness of breath.

Cotrimoxazole contraindications

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Cotrimoxazole is contraindicated in individuals hypersensitive to trimethoprim and in those with documented megaloblastic anemia due to folate deficiency.

Active ingredient matches for Cotrimoxazole:

Co-Trimoxazole

Sulfamethoxazole/Trimethoprim

Sulphamethoxazole/trimethoprim in India.


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Sulfamethoxazole 800 mg; Trimethoprim 160 mg
Suspension; Oral; Sulfamethoxazole 200 mg; Trimethoprim 40 mg / 5 ml
Tablet; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg
500's$ 10.71
Tablets; Oral; Sulfamethoxazole 800 mg; Trimethoprim 160 mg
Tablets; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg
Cotrimoxazole Sulphamethoxazole 800 mg, Trimethoprim 160 mg. TAB / 500$ 10.71
Cotrimoxazole 400+80 Tablet$ 0.01
Cotrimoxazole 50 ml Syrup$ 0.02
COTRIMOXAZOLE 800MG/160MG TABLET 1 strip / 10 tablets each (Cadila Pharmaceuticals Ltd)$ 0.23
COTRIMOXAZOLE / CLARIS tab 10's (Claris)$ 0.21
Cotrimoxazole Tablet (Geno Pharmaceuticals Ltd)$ 0.02

List of Cotrimoxazole substitutes (brand and generic names):

COTRIMOXAZOLE 160MG TABLET 1 strip / 10 tablets each (Cadila Pharmaceuticals Ltd)$ 0.18
Cotrimoxazole Heromycin-D syrup 60 mL
10's (AstraZeneca)$ 0.22
Cotrimoxazole-DS Sulfamethooxazole800mg, Trimethoprim 160mg TAB / 10 (AstraZeneca)$ 0.22
COTRIMOXAZOLE-DS / ASTRAZENECA tab 10's (AstraZeneca)$ 0.22
Cotrimoxazole-DS Sulfamethooxazole800mg, Trimethoprim 160mg TAB / 10 (AstraZeneca)$ 0.22
Suspension; Oral; Sulfamethoxazole 200 mg; Trimethoprim 40 mg / 5 ml (Stada)
Tablet; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg (Stada)
Tablets; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg (Stada)
Tablet; Oral; Sulfamethoxazole 800 mg; Trimethoprim 160 mg
CotrimStada Forte 2 Blister x 10 Tablet
Tablets; Oral; Sulfamethoxazole 800 mg; Trimethoprim 160 mg
Tablet; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg (Praxipharm)
Tablets; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg (Praxipharm)
Cotrizol 1000 g
Cotrizol 10 Blister x 20 Tablet
Cotrizol 50 Blister x 20 Tablet
1's (Medicon)$ 0.08
Cotrizole Trimethoprim 80 mg, Sulphamethoxazole 400 mg/5 mL. AMP / 1 (Medicon)$ 0.08
COTRIZOLE inj 5ml (Medicon)$ 0.08
Cotrizole Trimethoprim 80 mg, Sulphamethoxazole 400 mg/5 mL. AMP / 1 (Medicon)$ 0.08
Coyenlin 1000's
CTR 60 mL (Liptis)$ 1.44
CTR 100's (Liptis)$ 11.11

References

  1. DailyMed. "SULFAMETHOXAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "POLYMYXIN B SULFATE; TRIMETHOPRIM SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "trimethoprim". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Cotrimoxazole are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cotrimoxazole. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


2 consumers reported time for results

To what extent do I have to use Cotrimoxazole before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Cotrimoxazole. To get the time effectiveness of using Cotrimoxazole drug by other patients, please click here.
Users%
5 days2
100.0%


8 consumers reported age

Users%
16-294
50.0%
> 601
12.5%
46-601
12.5%
1-51
12.5%
< 11
12.5%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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