What is Cotrip Plus?
Cotrip Plus is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Cotrip Plus affects chemicals in the brain that may become unbalanced and cause anxiety.
Cotrip Plus is used to treat anxiety disorders or alcohol withdrawal.
Cotrip Plus may also be used for other purposes not listed in this medication guide.
Cotrip Plus indications
Cotrip Plus (Cotrip Plus) is indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal" symptoms of acute alcoholism, and preoperative apprehension and anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
The effectiveness of Cotrip Plus (Cotrip Plus) in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
How should I use Cotrip Plus?
Use Cotrip Plus injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Cotrip Plus injection is usually administered as an injection at your doctor's office, hospital, or clinic.
- If you are using Cotrip Plus injection at home, carefully follow the injection procedures taught to you by your health care provider.
- If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
- Try to stay in bed for 3 hours after taking Cotrip Plus injection.
- Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
- If you miss a dose of Cotrip Plus injection and you are using it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Cotrip Plus injection.
Uses of Cotrip Plus in details
Cotrip Plus is used to treat anxiety and acute alcohol withdrawal. It is also used to relieve fear and anxiety before surgery. This medication belongs to a class of drugs called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA).
How to use Cotrip Plus
Take this medication by mouth as directed by your doctor. The dosage is based on your age, medical condition, and response to treatment.
Use this medication exactly as prescribed. Do not increase your dose, take it more frequently or use it for a longer period of time than prescribed because this drug can be habit-forming. Also, if used for an extended period of time, do not suddenly stop using this drug without your doctor's approval. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased to avoid side effects such as seizures.
When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.
Cotrip Plus description
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Cotrip Plus has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Cotrip Plus is a controlled substance in the U.S.
Cotrip Plus dosage
Because of the wide range of clinical indications for Cotrip Plus (Cotrip Plus), the optimum dosage varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects.
|ADULTS||USUAL DAILY DOSE|
|Relief of Mild and Moderate Anxiety Disorders and Symptoms of Anxiety||5 mg or 10 mg, 3 or 4 times daily|
|Relief of Severe Anxiety Disorders and Symptoms of Anxiety||20 mg or 25 mg, 3 or 4 times daily|
|Geriatric Patients, or in the presence of debilitating disease.||5 mg, 2 to 4 times daily|
Preoperative Apprehension and Anxiety: On days preceding surgery, 5 to 10 mg orally, 3 or 4 times daily. If used as preoperative medication, 50 to 100 mg IM* 1 hour prior to surgery.
|PEDIATRIC PATIENTS||USUAL DAILY DOSE|
|Because of the varied response of pediatric patients to CNS-acting drugs, therapy should be initiated with the lowest dose and increased as required. Since clinical experience in pediatric patients under 6 years of age is limited, the use of the drug in this age group is not recommended.||5 mg, 2 to 4 times daily (may be increased in some pediatric patients to 10 mg, 2 to 3 times daily)|
For the relief of withdrawal symptoms of acute alcoholism, the parenteral form* is usually used initially. If the drug is administered orally, the suggested initial dose is 50 to 100 mg, to be followed by repeated doses as needed until agitation is controlled up to 300 mg per day. Dosage should then be reduced to maintenance levels.
* See package insert for Injectable Cotrip Plus (Cotrip Plus HCI).
Cotrip Plus (Cotrip Plus HCI) Capsules are available in the following presentations:
5 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3750-10), with Cotrip Plus (Cotrip Plus) 5 imprinted on the opaque green cap and ICN imprinted on the opaque yellow body.
10 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3751-10), with Cotrip Plus (Cotrip Plus) 10 imprinted on the opaque black cap and ICN imprinted on the opaque green body.
25 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3758-10), with Cotrip Plus (Cotrip Plus) 25 imprinted on the opaque green cap and ICN imprinted on the opaque white body.
Store at 25°C (77°F); excursions permitted to 15°C - 30°C (59°F - 86°F).
Vaieant Pharmaceuticals International Costa Mesa, CA 92626. Rev. July 2005. FDA rev date: 9/6/2002
Cotrip Plus interactions
When this drug applied simultaneously with:
- antipsychotic drugs (neuroleptics), antidepressants, sedatives, hypnotics, anesthetics, analgesics, ethanol enhanced the inhibitory effect on central nervous system, especially when administered parenterally.
- concomitant use of antacids can delay but not reduce the absorption of Cotrip Plus.
- hormonal contraceptives increases the effectiveness of Cotrip Plus.
- with muscle relaxants may enhance the action of muscle relaxants, with levodopa - may suppress antiparkinsonian action.
- theophylline at low doses perverts sedative effect of Cotrip Plus.
- phenobarbital and phenytoin may accelerate the metabolism of Cotrip Plus. In rare cases this medication inhibits the metabolism and enhances the action of phenytoin.
- may increase the toxicity of cyclophosphamide.
- cimetidine, omeprazole, disulfiram may increase the intensity and duration of action of this medicine.
Cotrip Plus side effects
The necessity of discontinuing therapy because of undesirable effects has been rare. Drowsiness, ataxia and confusion have been reported in some patients particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.
Other adverse reactions reported during therapy include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extrapyramidal symptoms, as well as increased and decreased libido. Such side effects have been infrequent, and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after Cotrip Plus (Cotrip Plus) treatment.
Blood dyscrasias (including agranulocytosis), jaundice and hepatic dysfunction have occasionally been reported during therapy. When Cotrip Plus (Cotrip Plus) treatment is protracted, periodic blood counts and liver function tests are advisable.
DRUG ABUSE AND DEPENDENCE: Cotrip Plus hydrochloride capsules are classified by the Drug Enforcement Administration as a Schedule IV controlled substance.
Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of Cotrip Plus. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving Cotrip Plus or, other, psychotropic agents because of the predisposition of such patients to habituation and dependence.
Cotrip Plus contraindications
Do not use this medication if you are allergic to Cotrip Plus or to other benzodiazepines, such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).
This medication can cause birth defects in an unborn baby. Do not use Cotrip Plus if you are pregnant.
Before taking Cotrip Plus, tell your doctor if you have any breathing problems, glaucoma, porphyria, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.
Do not drink alcohol while taking Cotrip Plus. This medication can increase the effects of alcohol.
Tell your doctor if you regularly use other medicines that make you sleepy. They can add to sleepiness caused by Cotrip Plus.
Cotrip Plus may be habit-forming and should be used only by the person it was prescribed for. Cotrip Plus should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
Active ingredient matches for Cotrip Plus:
|Unit description / dosage (Manufacturer)||Price, USD|
|Cotrip Plus 5+12.5 Tablet||$ 0.02|
List of Cotrip Plus substitutes (brand and generic names):
|Cotrip H 5+25 Tablet (Consern Pharma Pvt Ltd.)||$ 0.02|
|Curefit 10+1 Tablet (Cure Quick Remedies)||$ 0.02|
|Cyclogun 10+5+2.5 Tablet (Oyster Labs Limited)||$ 0.03|
|Cynosleep Chlordiazepoxide 10 mg, Trifluoperazine 1 mg. TAB / 10 (Cyno Pharmaceuticals Ltd.)||$ 0.26|
|10's (Cyno Pharmaceuticals Ltd.)||$ 0.26|
|Cynosleep 10+1 Tablet (Cyno Pharmaceuticals Ltd.)||$ 0.03|
|CYNOSLEEP tab 10's (Cyno Pharmaceuticals Ltd.)||$ 0.26|
|Czep 10 mg Tablet (Marsha Pharma Pvt. Ltd.)||$ 0.02|
|Czep CL 5+2.5 Tablet (Marsha Pharma Pvt. Ltd.)||$ 0.03|
|Czep F 25+10 Tablet (Marsha Pharma Pvt. Ltd.)||$ 0.03|
|Defobin (Czech Republic)|
|Dep 37 Tablet|
|Dep 37 Tablet (Elite Pharma Pvt Ltd)||$ 0.03|
|Depcon 10+5+2.5 Tablet (Unisharp Pharmaceuticals)||$ 0.04|
|Depof 37 Tablet|
|Depof 37 Tablet (Talent Healthcare)||$ 0.04|
|DEPOXIL tab 10 mg x 10's (Intra Life (Doxis))||$ 0.33|
|DEPOXIL tab 25 mg x 10's (Intra Life (Doxis))||$ 0.48|
|Depsodep Chlordiazepoxide 10 mg, Imipramine hydrochloride 25mg. TAB / 10 (Psychotropics India Limited)||$ 0.19|
|10's (Psychotropics India Limited)||$ 0.19|
|Depsodep 25+10 Tablet (Psychotropics India Limited)||$ 0.02|
|DEPSODEP 25MG/10MG TABLET 1 strip / 10 tablets each (Psychotropics India Limited)||$ 0.30|
|Depsodep 25 mg/10 mg Tablet (Psychotropics India Limited)||$ 0.03|
|Dertin 10 mg|
|Dibrium 10 mg Tablet (Mano (Orchid Chemicals & Pharmaceuticals Ltd.))||$ 0.02|
|Dipoxido 10 mg x 500's|
|Dipoxido 10 mg x 1000's|
|Dorpep Clidinium bromide 2.5 mg, Chlordiazepoxide 5 mg. TAB / 10 (Candor (Aileron))|
|10's (Candor (Aileron))|
|DORPEP tab 10's (Candor (Aileron))|
|10 mg x 10's (East West)||$ 0.38|
|25 mg x 10's (East West)||$ 0.55|
|Ebrium 10mg TAB / 10 (East West)||$ 0.38|
|Ebrium 25mg TAB / 10 (East West)||$ 0.55|
|EBRIUM tab 10 mg x 10's (East West)||$ 0.38|
|EBRIUM tab 25 mg x 10's (East West)||$ 0.55|
|Ebrium 10mg TAB / 10 (East West)||$ 0.38|
|Ebrium 25mg TAB / 10 (East West)||$ 0.55|
|Eden 50mg x 5mL TAB / 30ml (Eden)||$ 0.71|
- DailyMed. "AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "chlordiazepoxide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "chlordiazepoxide". http://www.drugbank.ca/drugs/DB00475 (accessed September 17, 2018).
ReviewsThe results of a survey conducted on ndrugs.com for Cotrip Plus are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cotrip Plus. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
1 consumer reported usefulWas the Cotrip Plus drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
1 consumer reported price estimatesWas the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Cotrip Plus drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Consumer reported time for resultsNo survey data has been collected yet
1 consumer reported age
There are no reviews yet. Be the first to write one!
Information checked by Dr. Sachin Kumar, MD Pharmacology