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Cpz Pregnancy |
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Cpz has not been formally assigned to a pregnancy category by the FDA. The drug has been frequently used in all stages of pregnancy for treatment of nausea and vomiting. Studies of a possible teratogenic effect have been conflicting. Use during labor is occasionally associated with hypotension which can be dangerous to both mother and fetus. There are no controlled data in human pregnancy. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these neonates. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. Cpz should probably be avoided during labor. It should otherwise be given during pregnancy only when benefit outweighs risk.
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Cpz is excreted into human milk in small amounts. The American Academy of Pediatrics describes Cpz as a drug "whose effect on nursing infants is unknown but may be of concern". The Academy also notes drowsiness and lethargy in the infant and galactorrhea in the adult as reasons for concern.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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