What is Cronmolin?
Cronmolin is used to relieve mental depression, including anxiety that sometimes occurs with depression.
Cronmolin is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Cronmolin is used in certain patients with the following medical condition:
- Chronic neurogenic pain (a certain type of pain that is continuing)
Cronmolin hydrochloride tablets are indicated for the treatment of depressive illness in patients with depressive neurosis (dysthymic disorder) and manic depressive illness, depressed type (major depressive disorder). Cronmolin is also effective for the relief of anxiety associated with depression.
How should I use Cronmolin?
Use Cronmolin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Cronmolin comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Cronmolin refilled.
- Take Cronmolin by mouth with or without food.
- Do not suddenly stop taking Cronmolin without checking with your doctor. You may have an increased risk of side effects. If you need to stop Cronmolin, your doctor may need to gradually lower your dose.
- Continue to use Cronmolin even if you feel well. Do not miss any doses.
- If you miss a dose of Cronmolin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Cronmolin.
Uses of Cronmolin in details
This medication is used to treat various types of depression and related anxiety. It may help improve mood and feelings of well-being. This medication belongs to a class of medications called tetracyclic antidepressants. It works by affecting the balance of certain natural chemicals (neurotransmitters) in the brain.
How to use Cronmolin
Read the Medication Guide provided by your pharmacist before you start taking Cronmolin and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth, usually 1 to 3 times daily or as directed by your doctor. If you take it only once a day, take it at bedtime to reduce daytime sleepiness. The dosage is based on your medical condition and response to treatment.
To reduce your risk of side effects (such as drowsiness, dry mouth, dizziness), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.
Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.
It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as mood swings, headache, and tiredness. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away.
This medication may not work right away. You may see some benefit within a week. However, it may take up to 3 weeks before you feel the full effect.
Tell your doctor if your condition persists or worsens (such as your feelings of sadness get worse, or you have thoughts of suicide).
Cronmolin is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, Cronmolin inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Cronmolin may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Cronmolin is effective at reducing symptoms of anxiety associated with depression.
A single daily dose is an alternative to divided daily doses. Therapeutic effects are sometimes seen within 3 to 7 days, although as long as 2 to 3 weeks are usually necessary.
Initial Adult Dosage
An initial dosage of 75 mg daily is suggested for outpatients with mild-to-moderate depression. However, in some patients, particularly the elderly, an initial dosage of 25 mg daily may be used. Because of the long half-life of Cronmolin, the initial dosage should be maintained for two weeks. The dosage may then be increased gradually in 25-mg increments as required and tolerated. In most outpatients a maximum dose of 150 mg daily will result in therapeutic efficacy. It is recommended that this dose not be exceeded except in the most severely depressed patients. In such patients, dosage may be gradually increased to a maximum of 225 mg.
More severely depressed, hospitalized patients should be given an initial daily dose of 100 mg to 150 mg which may be gradually increased as required and tolerated. Most hospitalized patients with moderate-to-severe depression respond to a daily dose of 150 mg although dosages as high as 225 mg may be required in some cases. Daily dosage of 225 mg should not be exceeded.
In general, lower dosages are recommended for patients over 60 years of age. Dosages of 50 mg to 75 mg daily are usually satisfactory as maintenance therapy for elderly patients who do not tolerate higher amounts.
Dosage during prolonged maintenance therapy should be kept at the lowest effective level. Dosage may be reduced to levels of 75 mg to 150 mg daily during such periods, with subsequent adjustment depending on therapeutic response.
May interact with the following: alcoholic beverages, barbiturates, and other CNS depressants (response may be exaggerated), adrenergic neuron blocking drugs (Cronmolin may diminish or abolish the antihypertensive effects of these drugs), beta-blockers subject to substantial biotransformation, such as propranolol (concomitant use may increase the plasma concentrations of Cronmolin), sympathomimetic drugs such as noradrenaline, adrenaline, and methylphenidate (Cronmolin may potentiate the cardiovascular effects of these drugs), and Cronmolin may also potentiate the effects of anticholinergic drugs (atropine, biperiden) and levodopa. Drugs that activate hepatic microsomal enzymes, such as barbiturates, phenytoin, oral contraceptives and carbamazepine, may accelerate the metabolism of Cronmolin resulting in decreased antidepressant efficacy. Concomitant administration of phenytoin and Cronmolin may increase serum phenytoin levels resulting in manifestation of the latters side-effects. Concomitant treatment with Cronmolin and major tranquilizers may result in increased plasma levels of Cronmolin, a lowered convulsion threshold, and seizures. The combination of Cronmolin and benzodiazepines may cause increased sedation. Cronmolin should not be administered for a period of at least 14 days after the discontinuation of treatment with MAO-inhibitors due to the potential of severe interactions. Concurrent use of parenteral magnesium sulfate and Cronmolin may result in serious potentiation of CNS depressant effects.
Cronmolin side effects
The following adverse reactions have been noted with Cronmolin and are generally similar to those observed with tricyclic antidepressants.
Cardiovascular: Rare occurrences of hypotension, hypertension, tachycardia, palpitation, arrhythmia, heart block, and syncope have been reported with Cronmolin.
Psychiatric: Nervousness (6%), anxiety (3%), insomnia (2%), and agitation (2%); rarely, confusional states (especially in the elderly), hallucinations, disorientation, delusions, restlessness, nightmares, hypomania, mania, exacerbation of psychosis, decrease in memory, and feelings of unreality.
Neurological: Drowsiness (16%), dizziness (8%), tremor (3%), and, rarely, numbness, tingling, motor hyperactivity, akathisia, seizures, EEG alterations, tinnitus, extrapyramidal symptoms, ataxia, and dysarthria.
Anticholinergic: Dry mouth (22%), constipation (6%), and blurred vision (4%); rarely, accommodation disturbances, mydriasis, urinary retention, and delayed micturition.
Allergic: Rare instances of skin rash, petechiae, itching, photosensitization, edema, and drug fever.
Gastrointestinal: Nausea (2%) and, rarely, vomiting, epigastric distress, diarrhea, bitter taste, abdominal cramps and dysphagia.
Endocrine: Rare instances of increased or decreased libido, impotence, and elevation or depression of blood sugar levels.
Other: Weakness and fatigue (4%) and headache (4%); rarely, altered liver function, jaundice, weight loss or gain, excessive perspiration, flushing, urinary frequency, increased salivation, nasal congestion and alopecia.
Note: Although there have been only isolated reports of the following adverse reactions with Cronmolin, its pharmacologic similarity to tricyclic antidepressants requires that each reaction be considered when administering Cronmolin.
— Bone marrow depression, including agranulocytosis, eosinophilia, purpura, and thrombocytopenia, myocardial infarction, stroke, peripheral neuropathy, sublingual adenitis, black tongue, stomatitis, paralytic ileus, gynecomastia in the male, breast enlargement and galactorrhea in the female, and testicular swelling.
Voluntary reports of adverse events temporally associated with Cronmolin that have been received since market introduction and that may have no casual relationship with the drug include the following: interstitial pneumonitis which were in some cases associated with eosinophilia and increased liver enzymes, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Cronmolin is contraindicated in patients with known or suspected convulsive disorders, since it is known to lower the seizure threshold. It is also contraindicated in patients with a history of hypersensitivity to the drug, and in those with existing severe hepatic or renal damage or a history of severe blood dyscrasias. Patients with narrow angle glaucoma, or with urinary retention (i.e., due to prostatic disease) should not receive Cronmolin because of its anticholinergic properties. Cronmolin is contraindicated during the acute recovery phase following myocardial infarction in the presence of acute congestive heart failure, and in patients with conduction defects. Cronmolin should not be given in conjunction with, or within 14 days of treatment with a MAO inhibitor. Combined therapy of this type could lead to the appearance of serious interactions such as hyperpyrexia, tremors, generalized clonic convulsions, delirium and possible death. Cronmolin should not be employed, or should be withdrawn, in cases of acute poisoning with alcohol, hypnotics, analgesics or psychotropic drugs. Maptrotiline should not be used by children.
Active ingredient matches for Cronmolin:
Maprotiline in Japan.
List of Cronmolin substitutes (brand and generic names)
|Sort by popularity|
|Unit description / dosage (Manufacturer)||Price, USD|
|Epalon (Malta, Taiwan)|
|Epalon 5 mg x 1000's|
|Epalon 10 mg x 1000's|
|Keproline 25 mg|
|Ladiomil (Bosnia & Herzegowina, Croatia (Hrvatska), Slovenia)|
|Ludiomil (Austria, Bangladesh, Belgium, Brazil, Bulgaria, China, Colombia, Czech Republic, Denmark, France, Germany, Ghana, Greece, Guyana, Hungary, Iceland, Indonesia, Italy, Japan, Kenya, Libya, Luxembourg, Malaysia, Malta, New Zealand, Nigeria, Oman, Poland, Portugal, Romania, Russian Federation, Slovakia, Spain, Sudan, Sweden, Switzerland, Taiwan, Tanzania, Thailand, Tunisia, Turkey, Venezuela, Zimbabwe)|
|Drops; Oral; Maprotiline Resinate (Dolorgiet)|
|Injectable; Injection; Maprotiline Mesylate 25 mg / 2 ml (Dolorgiet)|
|Injectable; Injection; Maprotiline Mesylate 5 mg / ml (Dolorgiet)|
|Tablet, Film-Coated; Oral; Maprotiline Hydrochloride 10 mg (Dolorgiet)|
|Tablet, Film-Coated; Oral; Maprotiline Hydrochloride 25 mg (Dolorgiet)|
|Tablet, Film-Coated; Oral; Maprotiline Hydrochloride 50 mg (Dolorgiet)|
|Tablet, Film-Coated; Oral; Maprotiline Hydrochloride 75 mg (Dolorgiet)|
|Tablet; Oral; Maprotiline Hydrochloride 10 mg (Dolorgiet)|
|Tablet; Oral; Maprotiline Hydrochloride 25 mg (Dolorgiet)|
|Tablet; Oral; Maprotiline Hydrochloride 50 mg (Dolorgiet)|
|Tablet; Oral; Maprotiline Hydrochloride 75 mg (Dolorgiet)|
|Ludiomil 25 mg x 100's (Dolorgiet)||$ 76.33|
|100 tablet in 1 bottle (Dolorgiet)|
|Ludiomil 10 mg x 5 x 10's (Dolorgiet)||$ 24.49|
|Ludiomil 25 mg x 5 x 10's (Dolorgiet)||$ 35.46|
|Ludiomil 50 mg x 5 x 10's (Dolorgiet)||$ 55.85|
|Ludiomil 75 mg x 50's (Dolorgiet)||$ 79.72|
|Ludiomil 50 mg x 100's (Dolorgiet)||$ 137.47|
|Ludiomil 10 mg (Bulgaria, Hungary)|
|Ludiomil 25 mg (Austria, Bulgaria, Hungary)|
|Ludiomil 50 mg (Austria)|
|Ludiomil 75 mg (Austria, Hungary)|
|Ludios 25 mg x 5 x 10's (Soho)||$ 15.50|
|Maprolu (Germany, Luxembourg)|
|Injectable; Injection; Maprotiline Hydrochloride (Hexal)|
|Tablet, Film-Coated; Oral; Maprotiline Hydrochloride 10 mg (Hexal)|
|Tablet, Film-Coated; Oral; Maprotiline Hydrochloride 25 mg (Hexal)|
|Tablet, Film-Coated; Oral; Maprotiline Hydrochloride 50 mg (Hexal)|
|Tablet, Film-Coated; Oral; Maprotiline Hydrochloride 75 mg (Hexal)|
|Mapromil (Chile, Japan)|
- PubChem. "maprotiline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "maprotiline". http://www.drugbank.ca/drugs/DB00934 (accessed September 17, 2018).
- MeSH. "Adrenergic Uptake Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
ReviewsThe results of a survey conducted on ndrugs.com for Cronmolin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cronmolin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
Consumer reported usefulNo survey data has been collected yet
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Information checked by Dr. Sachin Kumar, MD Pharmacology