Cronmolin Dosage

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Dosage of Cronmolin in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Cronmolin Dosage

Applies to the following strength(s): 25 mg; 50 mg; 75 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Outpatients with Mild to Moderate Depression:

-Initial dose: 75 mg orally once a day or in divided doses

-Maintenance dose: 75 to 150 mg/day

-Maximum dose: 225 mg/day

Inpatients with Moderate to Severe Depression:

-Initial dose: 100 to 150 mg orally once a day or in divided doses

-Maintenance dose: 75 to 150 mg/day

-Maximum dose: 225 mg/day

Comments:

-Patients with mild to moderate depression should remain on the initial dose for at least 2 weeks. Titration should gradually increase in 25 mg increments.

-Therapeutic efficacy may be reached by most outpatients at 150 mg/day; however, hospitalized and/or severely depressed patients may require doses up to 225 mg/day.

Uses:

-Treatment of depressive illness in patients with dysthymic disorder/depressive neurosis and major depressive disorder/manic depressive illness, depressed type

-Relief of anxiety related to depression

Usual Geriatric Dose for Depression

Outpatients with Mild to Moderate Depression:

-Initial dose: 25 mg orally once a day or in divided doses

-Maintenance dose: 50 to 75 mg/day

Comment:

-Patients over the age of 60 years had a satisfactory response with a maintenance dose of 50 to 75 mg/day; this range should be considered for all patients, and especially in those who cannot tolerate higher doses.

Uses:

-Treatment of depressive illness in patients with dysthymic disorder/depressive neurosis and major depressive disorder/manic depressive illness, depressed type

-Relief of anxiety related to depression

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Pathological neutrophil depression: Discontinue therapy.

Precautions

US BOXED WARNING:

-SUICIDALITY AND ANTIDEPRESSANT DRUGS: Increased risk of suicidal thinking and behavior has been observed in children, adolescents, and young adults less than 24 years old. Patients should be monitored and closely observed for clinical worsening, suicidality, or unusual changes in behavior. Caregivers and family members should be advised of the need for close observation and communication with the healthcare provider.

Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

-See manufacturer product information.

Storage requirements:

-See manufacturer product information.

General:

-Clinical improvement may take up to 2 to 3 weeks, though some patients have shown clinical improvement in 3 to 7 days.

Monitoring:

-Leukocyte and WBC with differential, especially in patients who develop fever and/or sore throat

-Vision examination, especially in patients with narrow angle glaucoma and/or increased intraocular pressure

-Clinical worsening or suicidality

Patient advice:

-Warn patients to avoid abrupt discontinuation of this drug.

-Tell patients to immediately report any signs/symptoms of neutropenia/leukopenia, neuroleptic malignant syndrome, or tardive dyskinesia.

-Advise patients, and families/caregivers to monitor and report signs/symptoms of suicidality, and/or unusual behavior immediately to their healthcare provider (e.g., agitation, irritability,anxiety, panic attacks, insomnia, hostility, aggressiveness, impulsivity, akathisia, hypomania/mania).

-Patients should be advised to report all concurrent prescription and nonprescription medications or herbal products they are taking.

-Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery until the full effects of the drug are known.

-Patients should be advised to speak to a healthcare provider if they are pregnant, intend to become pregnant, or are breastfeeding.

More about Cronmolin

Consumer resources

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What other drugs will affect Cronmolin?

The following drugs can interact with Cronmolin. Tell your doctor if you are using any of these:

This list is not complete and there may be other drugs that can interact with Cronmolin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Cronmolin interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Cronmolin, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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May interact with the following: alcoholic beverages, barbiturates, and other CNS depressants (response may be exaggerated), adrenergic neuron blocking drugs (Cronmolin may diminish or abolish the antihypertensive effects of these drugs), beta-blockers subject to substantial biotransformation, such as propranolol (concomitant use may increase the plasma concentrations of Cronmolin), sympathomimetic drugs such as noradrenaline, adrenaline, and methylphenidate (Cronmolin may potentiate the cardiovascular effects of these drugs), and Cronmolin may also potentiate the effects of anticholinergic drugs (atropine, biperiden) and levodopa. Drugs that activate hepatic microsomal enzymes, such as barbiturates, phenytoin, oral contraceptives and carbamazepine, may accelerate the metabolism of Cronmolin resulting in decreased antidepressant efficacy. Concomitant administration of phenytoin and Cronmolin may increase serum phenytoin levels resulting in manifestation of the latters side-effects. Concomitant treatment with Cronmolin and major tranquilizers may result in increased plasma levels of Cronmolin, a lowered convulsion threshold, and seizures. The combination of Cronmolin and benzodiazepines may cause increased sedation. Cronmolin should not be administered for a period of at least 14 days after the discontinuation of treatment with MAO-inhibitors due to the potential of severe interactions. Concurrent use of parenteral magnesium sulfate and Cronmolin may result in serious potentiation of CNS depressant effects.


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References

  1. FDA/SPL Indexing Data. "2U1W68TROF: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  2. MeSH. "Adrenergic Uptake Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
  3. European Chemicals Agency - ECHA. "maprotiline: The European Chemicals Agency (ECHA) is an agency of the European Union which is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness.". https://echa.europa.eu/ (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Cronmolin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cronmolin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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