Cyproterone acetate/Ethinylestradiol Uses

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Cyproterone acetate/Ethinylestradiol indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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androgen-associated acne, alopecia, hirsutism, and seborrhoea in women, combined oral contraceptive in women with androgenic symptoms

Cyproterone acetate/Ethinylestradiol dosage

1 tab daily starting on the 1st day of menstrual cycle for 21 days followed by a tab-free interval of 7 days.

Cyproterone acetate/Ethinylestradiol interactions

The efficacy of the contraceptive pill may be decreased in the case of irregular tablet-taking or when it is administered concomitantly with other medicines such as the anti-epileptic agents, antibiotics, barbiturates and rifampicin, and in patients with very rare individual metabolic disturbances (possible first symptom: intermenstrual bleeding). Mild laxatives do not impair the action of the tablets.

Oral contraceptive failure may occur with concomitant antibiotic therapy. For maximal protection, additional non-hormonal contraception should be recommended for the duration of antibiotic therapy and for seven days afterwards. Those on long-term antibiotic therapy need only take extra precautions for the first two weeks of antibiotic therapy.

Spotting and breakthrough bleeding are possible signs of diminished contraceptive effectiveness.

With vomiting or diarrhoea, the absorption of oral contraceptives may be diminished and women should be advised to use additional methods of contraception at the time of such disorders in order to prevent a possible pregnancy, which would be a compelling reason for the discontinuation of this medicine treatment.

Insulin and other hypoglycaemic requirements may change.

Effects on laboratory tests

Oral contraceptives may interfere with some laboratory estimations, in particular hormones, glucose tolerance, thyroid function, blood coagulation, serum triglycerides and liver function tests.

Cyproterone acetate/Ethinylestradiol side effects

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More common:

  • abdominal, cramping, or bloating

  • breast pain, tenderness, or swelling

  • dizziness

  • nausea

  • swelling of ankles and feet

  • unusual tiredness or weakness

  • vomiting

    Less common:

  • brown, blotchy spots on exposed skin

  • gain or loss of body or facial hair

  • increased or decreased interest in sexual intercourse

  • increased sensitivity of skin to sunlight

  • weight gain or loss.

    Cyproterone acetate/Ethinylestradiol contraindications

    Pregnancy; lactation; severe disturbances of liver function; recurrent cholestatic jaundice; jaundice or persistent itching during a previous pregnancy; Dubin-Johnson syndrome; Rotor syndrome; previous or existing liver tumours; existing or previous thromboembolic processes in arteries or veins and states which predispose to such diseases (eg disturbances of the clotting system with a tendency towards thrombosis, certain heart diseases); severe migraine or cerebrovascular insufficiency; sickle-cell anaemia; existing or treated cancer of the breast or the endometrium; undiagnosed vaginal bleeding; severe diabetes with vascular changes; disturbances of lipometabolism; a history of herpes of pregnancy; otosclerosis with deterioration in previous pregnancies.


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    Active ingredient matches for Cyproterone acetate/Ethinylestradiol:

    Cyproterone acetate/Ethinylestradiol


    List of Cyproterone acetate/Ethinylestradiol substitutes (brand and generic names)

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    Unit description / dosage (Manufacturer)Price, USD
    Diane-35 tab 21's (Bayer)

    References

    1. PubChem. "CYPROTERONE ACETATE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
    2. DrugBank. "CYPROTERONE ACETATE". http://www.drugbank.ca/drugs/DB04839 (accessed September 17, 2018).
    3. DTP/NCI. "CYPROTERONE ACETATE: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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    Information checked by Dr. Sachin Kumar, MD Pharmacology

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