What is Czep CL?
Czep CL is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Czep CL affects chemicals in the brain that may become unbalanced and cause anxiety.
Czep CL is used to treat anxiety disorders or alcohol withdrawal.
Czep CL may also be used for other purposes not listed in this medication guide.
Czep CL indications
Czep CL (Czep CL) is indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal" symptoms of acute alcoholism, and preoperative apprehension and anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
The effectiveness of Czep CL (Czep CL) in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
How should I use Czep CL?
Use Czep CL injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Czep CL injection is usually administered as an injection at your doctor's office, hospital, or clinic.
- If you are using Czep CL injection at home, carefully follow the injection procedures taught to you by your health care provider.
- If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
- Try to stay in bed for 3 hours after taking Czep CL injection.
- Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
- If you miss a dose of Czep CL injection and you are using it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Czep CL injection.
Uses of Czep CL in details
Czep CL is used to treat anxiety and acute alcohol withdrawal. It is also used to relieve fear and anxiety before surgery. This medication belongs to a class of drugs called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA).
How to use Czep CL
Take this medication by mouth as directed by your doctor. The dosage is based on your age, medical condition, and response to treatment.
Use this medication exactly as prescribed. Do not increase your dose, take it more frequently or use it for a longer period of time than prescribed because this drug can be habit-forming. Also, if used for an extended period of time, do not suddenly stop using this drug without your doctor's approval. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased to avoid side effects such as seizures.
When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.
Czep CL description
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Czep CL has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Czep CL is a controlled substance in the U.S.
Czep CL dosage
Because of the wide range of clinical indications for Czep CL (Czep CL), the optimum dosage varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects.
|ADULTS||USUAL DAILY DOSE|
|Relief of Mild and Moderate Anxiety Disorders and Symptoms of Anxiety||5 mg or 10 mg, 3 or 4 times daily|
|Relief of Severe Anxiety Disorders and Symptoms of Anxiety||20 mg or 25 mg, 3 or 4 times daily|
|Geriatric Patients, or in the presence of debilitating disease.||5 mg, 2 to 4 times daily|
Preoperative Apprehension and Anxiety: On days preceding surgery, 5 to 10 mg orally, 3 or 4 times daily. If used as preoperative medication, 50 to 100 mg IM* 1 hour prior to surgery.
|PEDIATRIC PATIENTS||USUAL DAILY DOSE|
|Because of the varied response of pediatric patients to CNS-acting drugs, therapy should be initiated with the lowest dose and increased as required. Since clinical experience in pediatric patients under 6 years of age is limited, the use of the drug in this age group is not recommended.||5 mg, 2 to 4 times daily (may be increased in some pediatric patients to 10 mg, 2 to 3 times daily)|
For the relief of withdrawal symptoms of acute alcoholism, the parenteral form* is usually used initially. If the drug is administered orally, the suggested initial dose is 50 to 100 mg, to be followed by repeated doses as needed until agitation is controlled up to 300 mg per day. Dosage should then be reduced to maintenance levels.
* See package insert for Injectable Czep CL (Czep CL HCI).
Czep CL (Czep CL HCI) Capsules are available in the following presentations:
5 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3750-10), with Czep CL (Czep CL) 5 imprinted on the opaque green cap and ICN imprinted on the opaque yellow body.
10 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3751-10), with Czep CL (Czep CL) 10 imprinted on the opaque black cap and ICN imprinted on the opaque green body.
25 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3758-10), with Czep CL (Czep CL) 25 imprinted on the opaque green cap and ICN imprinted on the opaque white body.
Store at 25°C (77°F); excursions permitted to 15°C - 30°C (59°F - 86°F).
Vaieant Pharmaceuticals International Costa Mesa, CA 92626. Rev. July 2005. FDA rev date: 9/6/2002
Czep CL interactions
When this drug applied simultaneously with:
- antipsychotic drugs (neuroleptics), antidepressants, sedatives, hypnotics, anesthetics, analgesics, ethanol enhanced the inhibitory effect on central nervous system, especially when administered parenterally.
- concomitant use of antacids can delay but not reduce the absorption of Czep CL.
- hormonal contraceptives increases the effectiveness of Czep CL.
- with muscle relaxants may enhance the action of muscle relaxants, with levodopa - may suppress antiparkinsonian action.
- theophylline at low doses perverts sedative effect of Czep CL.
- phenobarbital and phenytoin may accelerate the metabolism of Czep CL. In rare cases this medication inhibits the metabolism and enhances the action of phenytoin.
- may increase the toxicity of cyclophosphamide.
- cimetidine, omeprazole, disulfiram may increase the intensity and duration of action of this medicine.
Czep CL side effects
The necessity of discontinuing therapy because of undesirable effects has been rare. Drowsiness, ataxia and confusion have been reported in some patients particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.
Other adverse reactions reported during therapy include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extrapyramidal symptoms, as well as increased and decreased libido. Such side effects have been infrequent, and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after Czep CL (Czep CL) treatment.
Blood dyscrasias (including agranulocytosis), jaundice and hepatic dysfunction have occasionally been reported during therapy. When Czep CL (Czep CL) treatment is protracted, periodic blood counts and liver function tests are advisable.
DRUG ABUSE AND DEPENDENCE: Czep CL hydrochloride capsules are classified by the Drug Enforcement Administration as a Schedule IV controlled substance.
Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of Czep CL. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving Czep CL or, other, psychotropic agents because of the predisposition of such patients to habituation and dependence.
Czep CL contraindications
Do not use this medication if you are allergic to Czep CL or to other benzodiazepines, such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).
This medication can cause birth defects in an unborn baby. Do not use Czep CL if you are pregnant.
Before taking Czep CL, tell your doctor if you have any breathing problems, glaucoma, porphyria, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.
Do not drink alcohol while taking Czep CL. This medication can increase the effects of alcohol.
Tell your doctor if you regularly use other medicines that make you sleepy. They can add to sleepiness caused by Czep CL.
Czep CL may be habit-forming and should be used only by the person it was prescribed for. Czep CL should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
Active ingredient matches for Czep CL:
|Unit description / dosage (Manufacturer)||Price, USD|
|Czep CL 5+2.5 Tablet||$ 0.03|
List of Czep CL substitutes (brand and generic names):
|Czep F 25+10 Tablet (Marsha Pharma Pvt. Ltd.)||$ 0.03|
|Defobin (Czech Republic)|
|Dep 37 Tablet|
|Dep 37 Tablet (Elite Pharma Pvt Ltd)||$ 0.03|
|Depcon 10+5+2.5 Tablet (Unisharp Pharmaceuticals)||$ 0.04|
|Depof 37 Tablet|
|Depof 37 Tablet (Talent Healthcare)||$ 0.04|
|DEPOXIL tab 10 mg x 10's (Intra Life (Doxis))||$ 0.33|
|DEPOXIL tab 25 mg x 10's (Intra Life (Doxis))||$ 0.48|
|Depsodep Chlordiazepoxide 10 mg, Imipramine hydrochloride 25mg. TAB / 10 (Psychotropics India Limited)||$ 0.19|
|10's (Psychotropics India Limited)||$ 0.19|
|Depsodep 25+10 Tablet (Psychotropics India Limited)||$ 0.02|
|DEPSODEP 25MG/10MG TABLET 1 strip / 10 tablets each (Psychotropics India Limited)||$ 0.30|
|Depsodep 25 mg/10 mg Tablet (Psychotropics India Limited)||$ 0.03|
|Dertin 10 mg|
|Dibrium 10 mg Tablet (Mano (Orchid Chemicals & Pharmaceuticals Ltd.))||$ 0.02|
|Dipoxido 10 mg x 500's|
|Dipoxido 10 mg x 1000's|
|Dorpep Clidinium bromide 2.5 mg, Chlordiazepoxide 5 mg. TAB / 10 (Candor (Aileron))|
|10's (Candor (Aileron))|
|DORPEP tab 10's (Candor (Aileron))|
|10 mg x 10's (East West)||$ 0.38|
|25 mg x 10's (East West)||$ 0.55|
|Ebrium 10mg TAB / 10 (East West)||$ 0.38|
|Ebrium 25mg TAB / 10 (East West)||$ 0.55|
|EBRIUM tab 10 mg x 10's (East West)||$ 0.38|
|EBRIUM tab 25 mg x 10's (East West)||$ 0.55|
|Ebrium 10mg TAB / 10 (East West)||$ 0.38|
|Ebrium 25mg TAB / 10 (East West)||$ 0.55|
|Eden 50mg x 5mL TAB / 30ml (Eden)||$ 0.71|
|50 mg x 5 mL x 30ml (Eden)||$ 0.71|
|Tablets; Oral; Cefixime 50 mg (Eden)|
|EDEN SYRUP 1 bottle / 30 ML syrup each (Eden)||$ 0.49|
|EDEN dry syr 50 mg x 5 mL x 30ml (Eden)||$ 0.71|
|Eden NA Syrup (Eden)||$ 0.49|
|Elenium (Bulgaria, Czech Republic, Georgia, Hungary, Latvia, Lithuania, Poland, Russian Federation, Slovakia)|
|Tablet, Film-Coated; Oral; Chlordiazepoxide 10 mg (Polfa Tarchomin)|
|Tablets, Film-Coated; Oral; Chlordiazepoxide 10 mg (Polfa Tarchomin)|
|Elenium 5 mg (Hungary)|
- DailyMed. "AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "chlordiazepoxide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "chlordiazepoxide". http://www.drugbank.ca/drugs/DB00475 (accessed September 17, 2018).
ReviewsThe results of a survey conducted on ndrugs.com for Czep CL are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Czep CL. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
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Information checked by Dr. Sachin Kumar, MD Pharmacology