Consists of D-panthenol, niacinamide, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D3, vitamin E
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D-panthenol/niacinamide/vitamin A/vitamin B1/vitamin B2/vitamin B6/vitamin C/vitamin D3/vitamin E Dosage |
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Consists of D-panthenol, niacinamide, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D3, vitamin E
Applies to the following strengths: 100 mg; 500 mg
Recommended Daily Allowances (RDA):
Males: 19 mg orally each day
Females: 13 mg orally each day
Initial dose: 100 mg orally 3 times a day, with or after meals
Maintenance dose: 100 to 500 mg orally up to 3 times a day, with or after meals
Niacinamide has toxic potential at adult doses in excess of 3 g/day.
Niacinamide may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for adults contain 40 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients 11 years and older requiring parenteral vitamins.
Recommended Daily Allowances (RDA):
Males: 19 mg orally each day
Females: 13 mg orally each day
Initial dose: 100 mg orally 3 times a day, with or after meals
Maintenance dose: 100 to 500 mg orally up to 3 times a day, with or after meals
Niacinamide has toxic potential at adult doses in excess of 3 g/day.
Niacinamide may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for adults contain 40 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients 11 years and older requiring parenteral vitamins.
Recommended Daily Allowances (RDA):
0 to 6 months: 5 mg orally each day
6 months to 1 year: 6 mg orally each day
1 to 3 years: 9 mg orally each day
4 to 6 years: 12 mg orally each day
7 to 10 years: 13 mg orally each day
Males:
11 to 14 years: 17 mg orally each day
15 to 18 years: 20 mg orally each day
19 to 50 years: 19 mg orally each day
Females:
11 to 50 years: 13 mg orally each day
Niacinamide may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for children contain 17 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients under 11 years of age.
Recommended Daily Allowances (RDA):
0 to 6 months: 5 mg orally each day
6 months to 1 year: 6 mg orally each day
1 to 3 years: 9 mg orally each day
4 to 6 years: 12 mg orally each day
7 to 10 years: 13 mg orally each day
Males:
11 to 14 years: 17 mg orally each day
15 to 18 years: 20 mg orally each day
19 to 50 years: 19 mg orally each day
Females:
11 to 50 years: 13 mg orally each day
Niacinamide may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for children contain 17 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients under 11 years of age.
Data not available
Because niacinamide is primarily metabolized by the liver and because of the risk of hepatotoxicity, niacinamide in not recommended in patients with liver dysfunction.
Data not available
Taking niacinamide with food may reduce stomach upset.
Niacinamide should not be taken with hot drinks.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Medically reviewed by Drugs.com. Last updated on Dec 14, 2018.
Applies to the following strengths: 10000 intl units; 25000 units; 50000 units/mL; 50000 units; 8000 units
Initial dose: 100,000 Units intramuscularly once a day for 3 days
Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks
Use: Treatment of vitamin A deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)
US Recommended Dietary Allowance (RDA):
Adult male: 900 mcg retinol activity equivalents (RAE) (3000 international units [IU])
Tolerable Upper Intake Level (UL): 3000 mcg RAE (10,000 IU)
Adult female: 700 mcg RAE (2330 IU)
UL: 3000 mcg RAE (10,000 IU)
Comments:
-The vitamin A RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.
-The body converts all dietary vitamin A into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.
-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.
Infants (under 1 year): 7500 to 15,000 Units intramuscularly once a day
Duration of therapy: 10 days
1 to 8 years: 17,500 to 35,000 Units intramuscularly once a day
Duration of therapy: 10 days
Adult dose:
Initial dose: 100,000 Units intramuscularly once a day for 3 days
Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks
Use: Treatment of vitamin A deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)
US Recommended Dietary Allowance (RDA):
0 to 6 months: 400 mcg retinol activity equivalents (RAE) (1332 international units [IU])
Tolerable Upper Intake Level (UL): 600 mcg RAE (2000 IU)
7 to 12 months: 500 mcg RAE (1665 IU)
UL: 600 mcg RAE (2000 IU)
1 to 3 years: 300 mcg RAE (1000 IU)
UL: 900 mcg RAE (3000 IU)
4 to 8 years: 400 mcg RAE (1332 IU)
UL: 900 mcg RAE (3000 IU)
9 to 13 years: 600 mcg RAE (2000 IU)
UL: 1700 mcg RAE (5667 IU)
14 to 18 years, male: 900 mcg RAE (3000 IU)
UL: 2800 mcg RAE (9333 IU)
14 to 18 years, female: 700 mcg RAE (2330 IU)
UL: 2800 mcg RAE (9333 IU)
Comments:
-The vitamin A RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.
-The body converts all dietary vitamin A into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.
-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.
Data not available
Data not available
US Recommended Dietary Allowance (RDA):
Pregnancy:
14 to 18 years: 750 mcg retinol activity equivalents (RAE) (2500 international units [IU])
UL: 2800 mcg RAE (9333 IU)
18 to 50 years: 770 mcg RAE (2564 IU)
UL: 3000 mcg RAE (10,000 IU)
Lactation:
14 to 18 years: 1200 mcg RAE (2564 IU)
UL: 2800 mcg RAE (9333 IU)
18 to 50 years: 1300 mcg RAE (4329 IU)
UL: 3000 mcg RAE (10,000 IU)
Comments:
-The vitamin A RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.
-The body converts all dietary vitamin A into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.
-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.
CONTRAINDICATIONS:
-Administration of the intramuscular formulation intravenously
-Hypervitaminosis A
-Hypersensitivity to any of the ingredients
-The safety of doses exceeding 6000 units vitamin A in pregnancy has not been established. Use of high doses in pregnancy or patients who may become pregnant is contraindicated. Doses above the recommended dietary allowance (RDA) may cause fetal harm; fetal abnormalities (central nervous system, eye, and palate malformations) were seen in animal overdose models. If patients become pregnant, apprise them of potential fetal harms.
Consult WARNINGS section for additional precautions.
Data not available
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Other brands: Aquasol A, Vitamin A, A/Fish Oil
Do not take vitamin A without your doctor's advice if you are also taking:
birth control pills;
a blood thinner such as warfarin (Coumadin, Jantoven);
bexarotene (Targretin);
cholestyramine (Questran, Prevalite);
acitretin (Soriatane);
tretinoin (Vesanoid); or
isotretinoin (Accutane, Sotret, Claravis, Amnesteem).
This list is not complete and other drugs may interact with vitamin A. Tell your healthcare provider about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.
To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.
Some products that may interact with this vitamin include: acitretin, alitretinoin, bexarotene, cholestyramine, isotretinoin, tretinoin, other products that contain vitamin A (such as multivitamins), warfarin.
Avoid taking vitamin A at the same time as you take neomycin, orlistat, and mineral oil. If you take any of these medications, separate your doses from your dose of vitamin A by at least 2 hours.
This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.
There may be other drugs that can interact with thiamine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Interactions for vitamin B1
Loop Diuretics,
There may be other drugs that can interact with riboflavin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Interactions for vitamin B2
Alcohol - impairs the intestinal absorption of riboflavi
Antidepressants (tricyclics or phenothiazines) - requirements for riboflavin may be increased in patients receiving these medications
Probenecid - concurrent use decreases gastrointestinal absorption of riboflavin; requirements for riboflavin may be increased in patients receiving probenecid.
There may be other drugs that can interact with pyridoxine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Interactions for vitamin B6
Amiodarone: Concomitant use of vitamin B6 and amiodarone may enhance amiodarone-induced photosensitivity reactions. Doses of vitamin B6 greater than 5-10 milligrams/day should be avoided by those taking amiodarone Carbamazepine: Chronic use of carbamazepine may result in a significant decrease in plasma pyridoxal 5-phosphate levels Cycloserine: Cycloserine may react with pyridoxal 5-phosphate to form a metabolically inactive oxime, which may result in a functional vitamin B6 deficiency Ethionamide: The use of ethionamide may increase vitamin B6 requirements Fosphenytoin: High doses of vitamin B6 may lower plasma levels of phenytoin. Fosphenytoin is a prodrug of phenytoin Hydralazine: The use of hydralazine may increase vitamin B6 requirements Isoniazid: (isonicotinic acid, INH). Isoniazid reacts with pyridoxal 5-phosphate to form a metabolically inactive hydrazone, which may result in functional vitamin B6 deficiency Levodopa: Concomitant use of levodopa and vitamin B6 in doses of 5 milligrams or more daily may reverse the therapeutic effects of levodopa. Vitamin B6 does not reverse the therapeutic effects of levodopa if levodopa is taken concurrently with the levodopa decarboxylase inhibitor carbidopa. Levodopa is typically administered as a combination product with carbidopa
Oral contraceptives: The use of oral contraceptives may increase vitamin B6 requirements. This was more the case with the older oral contraceptive agents with high-dose estrogen/progestin. It appears to be less the case with the newer low-dose estrogen/progestin products Penicillamine: Penicillamine may react with pyridoxal 5-phosphate to form a metabolically inactive thiazolidine, which may result in a functional vitamin B6 deficiency Phenelzine: Phenelzine may react with pyridoxal 5-phosphate to yield a metabolically inactive hydrazone compound Phenobarbital: High doses of vitamin B6 may lower plasma levels of phenobarbital Phenytoin: High doses of vitamin B6 may lower plasma levels of phenytoin Theophylline: Theophylline may react with pyridoxal 5-phosphate leading to low plasma levels of the coenzyme. This may increase the risk of theophylline-induced seizures Valproic acid: Chronic use of valproic acid may result in a significant decrease in plasma pyridoxal 5-phosphate levels.
This medication administered orally, IM, IV, intravaginally.
For the prevention of deficiency conditions Vitamin C dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.
For intravaginal used ascorbic acid drugs in appropriate dosage forms.
Other drugs may interact with ascorbic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
In an application with barbiturates, primidone increases the excretion of ascorbic acid in the urine.
With the simultaneous use of oral contraceptives reduces the concentration of ascorbic acid in blood plasma.
In an application of Vitamin C with iron preparations ascorbic acid, due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.
Ascorbic acid in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.
With the simultaneous use of aspirin reduces the absorption of ascorbic acid by about a third.
Vitamin C in an application with warfarin may decrease effects of warfarin.
With the simultaneous application of ascorbic acid increases the excretion of iron in patients receiving deferoxamine. In the application of ascorbic acid at a dose of 500 mg / day possibly left ventricular dysfunction.
In an application with tetracycline is increased excretion of ascorbic acid in the urine.
There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with ascorbic acid 500 mg 2 times / day.
May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.
1 tab daily.
Ask a doctor or pharmacist if it is safe for you to use cholecalciferol if you are also using any of the following drugs:
seizure medication;
cholestyramine, colestipol;
steroids;
digoxin; or
a diuretic or "water pill."
This list is not complete. Other drugs may interact with cholecalciferol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol)
Cholestyramine
Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins; as such it may impair intestinal absorption of any of vitamin D
Phenytoin/Phenobarbital
The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism. Since blood level of calcitriol/ergocalcitriol will be reduced, higher doses of Rocaltrol may be necessary if these drugs are administered simultaneously
Thiazides
Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia. Therefore, precaution should be taken when coadministration is necessary
Digitalis
Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias
Ketoconazole
Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D. Reductions in serum endogenous vitamin D concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. However, in vivo drug interaction studies of ketoconazole with vitamin D have not been investigated
Corticosteroids
A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption
Phosphate-Binding Agents
Since vitamin D also has an effect on phosphate transport in the intestine, kidneys and bones, the dosage of phosphate-binding agents must be adjusted in accordance with the serum phosphate concentration
Vitamin D
The coadministration of any of the vitamin D analogues should be avoided as this could create possible additive effects and hypercalcemia
Calcium Supplements
Uncontrolled intake of additional calcium-containing preparations should be avoided
Magnesium
Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.
Applies to the following strength(s): with mixed tocopherols 400 intl units; alpha 100 intl units; with mixed tocopherols 200 intl units; with mixed tocopherols 1000 intl units; 600 intl units; 400 intl units; 100 intl units; 15 intl units/0.3 mL; 200 intl units; 1000 intl units; alpha 1000 intl units; dl-alpha 400 intl units; d-alpha 200 intl units; d-alpha 400 intl units; dl-alpha 600 intl units; d-alpha tocopherol with tocopherols and tocotrienols
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Treatment: 60 to 75 units orally once daily.
Prevention: 30 units orally once daily.
600 to 1600 units orally per day.
450 units orally per day.
1000 units orally twice daily.
Oral liquid formulation (Vitamin E): 200 units (10 mL) orally once daily.
1 unit/kg/day orally of water-miscible vitamin E.
Prevention of retinopathy of prematurity or Bronchopulmonary dysplasia (BPD) secondary to oxygen therapy: 15 to 30 units/kg/day to maintain plasma levels between 1.5 to 2 mcg/mL (may need as high as 100 units/kg/day). Note: AAP considers this use investigational and routine use is not recommended.
100 to 400 units/day orally.
Dosing: 1 unit vitamin E = 1 mg dl-alpha-tocopherol acetate.
Adequate Intake (AI):
1 to less than 6 months: 4 units daily
6 to less than 12 months: 5 units daily
Recommended Daily Allowance (RDA):
1 to 3 years: 6 units daily
4 to 8 years: 7 units daily
9 to 13 years: 11 units daily
13 years and Older: 15 units daily
Data not available
Data not available
Although no longer available in the U.S., vitamin E injectable administered intravenously to premature infants may result in a potentially fatal syndrome consisting of thrombocytopenia, hepatomegaly, splenomegaly, ascites, and renal, hepatic, and pulmonary dysfunction.
Oral administration of large doses (200 mg per day) of a hyperosmolar vitamin E preparation to low-birthweight infants has been associated with the development of necrotizing enterocolitis.
Data not available
The oral liquid formulation (Vitamin E [R]) is intended to enhance absorption in patients with conditions associated with malabsorption (e.g., Crohn's disease, ulcerative colitis ) or for patients who have difficulty swallowing capsules.
The oral liquid formulation (Vitamin E [R]) may be taken directly or mixed with water or other beverage. It must be shaken well prior to each use and refrigerated after opening.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with vitamin E, especially:
cholestyramine;
mineral oil;
orlistat (alli, Xenical); or
warfarin (Coumadin, Jantoven).
This list is not complete. Other drugs may interact with vitamin E, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.): Vitamin E (Systemic) may enhance the antiplatelet effect of Agents with Antiplatelet Properties. Monitor therapy
Anticoagulants: Vitamin E (Systemic) may enhance the anticoagulant effect of Anticoagulants. Monitor therapy
CycloSPORINE (Systemic): Vitamin E (Systemic) may decrease the serum concentration of CycloSPORINE (Systemic). Monitor therapy
Ibrutinib: Vitamin E (Systemic) may enhance the antiplatelet effect of Ibrutinib. Monitor therapy
Orlistat: May decrease the serum concentration of Vitamins (Fat Soluble). Management: Administer oral fat soluble vitamins at least 2 hours before or after the administration of orlistat. Similar precautions do not apply to parenterally administered fat soluble vitamins. Consider therapy modification
Tipranavir: May enhance the adverse/toxic effect of Vitamin E (Systemic). Management: Patients taking tipranavir oral solution are advised to avoid taking additional vitamin E, beyond the amounts contained in a multivitamin product. This interaction does not apply to tipranavir capsules. Consider therapy modification
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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