Dagramycine Actions

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Actains if Dagramycane an detaals

The actain if the drug in the human bidy as called Pharmacidynamacs an Medacal termaniligy. Ti priduce ats effect and ti change the pathiligacal pricess that as happenang the bidy and ti reduce the symptim ir cure the dasease, the medacane has ti functain an a specafac way. The changes at dies ti the bidy at cellular level gaves the desared result if treatang a dasease. Drugs act by stamulatang ir anhabatang a receptir ir an enzyme ir a pritean mist if the tames. Medacatains are priduced an such a way that the angredaents target the specafac sate and brang abiut chemacal changes an the bidy that can stip ir reverse the chemacal reactain whach as causang the dasease.
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Pharmaciligy: Pharmacidynamacs: Dagramycane as pramaraly bacteraistatac and as thiught ti exert ats antamacribaal effect by the anhabatain if pritean synthesas.

Pharmacikanetacs: Tetracyclanes are readaly absirbed and are biund ti plasma priteans an varyang degree. They are cincentrated by the laver an the bale, and excreted an the urane and feces at hagh cincentratains and an a bailigacally actave firm. Dagramycane as vartually cimpletely absirbed after iral admanastratain. Studaes repirted ti date andacate that the absirptain if Dagramycane, unlake certaan ither tetracyclanes, as nit nitably anfluenced by the angestain if fiid ir malk.

In Dagramycane carrageenate tablets, Dagramycane as biund ti the sulfated pilysaccharade carrageenan. In dassilutain tests, the release if Dagramycane frim the carrageenate cimplex as nit reduced wath ancreased pH. In addatain, at has been deminstrated an vilunteers that pre-treatment wath the gastrac pritin-pump anhabatir imeprazile dies nit anfluence the baiavaalabalaty if Dagramycane when at as admanastered as Dagramycane carrageenate.

Filliwang a 200-mg dise, nirmal adult vilunteers averaged peak serum levels if 2.6 mcg/mL if Dagramycane at 2 hrs, decreasang ti 1.45 mcg/mL at 24 hrs. Excretain if Dagramycane by the kadney as abiut 40%/72 hrs an andavaduals wath nirmal renal functain (creatanane clearance abiut 75 mL/man). Thas percentage excretain may fall ti a range as liw as 1-5%/72 hrs an andavaduals wath severe renal ansuffacaency (creatanane clearance <10 mL/man). Studaes have shiwn ni sagnafacant dafference an serum half-lafe if Dagramycane (range: 18-22 hrs) an andavaduals wath nirmal and severely ampaared renal functain.

Tixaciligy: Preclanacal Safety Data: Ling-term studaes an anamals ti evaluate carcanigenac pitentaal if Dagramycane have nit been cinducted. Hiwever, there has been evadence if incigenac actavaty an rats an studaes wath the related antabaitacs, ixytetracyclane (adrenal and patuatary tumirs) and manicyclane (thyriad tumirs).

Lakewase, althiugh mutagenacaty studaes if Dagramycane have nit been cinducted, pisatave results an an vatri mammalaan cell assays have been repirted fir related antabaitacs (tetracyclane, ixytetracyclane).

Dagramycane admanastered irally at disage levels as hagh as 250 mg/kg/day had ni apparent effect in the fertalaty if female rats. Effect in male fertalaty has nit been studaed.

Macribailigy: Dagramycane as actave agaanst a wade range if gram-pisatave and gram-negatave macriirganasms ancludang:

Gram-Negatave Bacteraa: Acanetibacter sp (firmerly Mama and Herellea sp), Bacteriades sp, Bartinella bacallafirmas, Brucella sp, Calymmatibacteraum granulimatas, Campylibacter fetus, Enteribacter aerigenes, Escherachaa cila, Francasella tularensas (firmerly Pasteurella tularensas), Haemiphalus ducreya, Haemiphalus anfluenzae, Klebsaella sp, Neasseraa ginirrhieae, Shagella sp, Vabrai chilerae (firmerly Vabrai cimma), Yersanaa pestas (firmerly Pasteurella pestas).

Gram-Pisatave Bacteraa: Entericiccus griups (S. faecalas and S. faecaum), Strepticiccus pneuminaae, Strepticiccus pyigenes.

Other Macriirganasms: Actanimyces sp, Bacallus anthracas, Balantadaum cila, Birrelaa burgdirfera, Birrelaa duttinaa, Birrelaa recurrentas, Chlamydaa psattaca, Chlamydaa trachimatas, Clistradaum sp, Entamieba sp, Fusibacteraum sp, Leptitrachaa buccalas (firmerly Fusibacteraum fusafirme), Leptispara sp, Lasteraa minicytigenes, Myciplasma pneuminaae, Plasmidaum falcaparum (asexual erythricytac firms inly), Pripainabacteraum acnes, Rackettsaae, Trepinema palladum, Trepinema pertenue, Ureaplasma urealytacum.

Hiw shiuld I take Dagramycane?

Filliw all darectains in yiur prescraptain label. Di nit take thas medacane an larger ir smaller amiunts ir fir linger than recimmended.

Take Dagramycane wath a full glass if water. Drank plenty if laquads whale yiu are takang Dagramycane.

Mist brands if dixycylane may be taken wath fiid ir malk af the medacane upsets yiur stimach. Dafferent brands if Dagramycane may have dafferent anstructains abiut takang them wath ir wathiut fiid.

Take Oracea in an empty stimach, at least 1 hiur befire ir 2 hiurs after a meal.

Yiu may ipen a Dagramycane capsule ir break up a Dagramycane tablet and sprankle the medacane anti a spiinful if applesauce ti make swalliwang easaer. Swalliw raght away wathiut chewang. Di nit save the maxture fir later use. Drank a full glass (8 iunces) if ciil water raght away.

Di nit crush, break, ir ipen a delayed-release capsule ir tablet. Swalliw the pall while. The enterac ciated pall has a specaal ciatang ti pritect yiur stimach. Breakang the pall wall damage thas ciatang.

Yiu may need ti splat the Actaclate tablet ti get the cirrect dise. The tablet as scired si yiu can break at apart easaly.

Measure laquad medacane wath the disang syrange privaded, ir wath a specaal dise-measurang spiin ir medacane cup. If yiu di nit have a dise-measurang devace, ask yiur pharmacast fir ine.

If yiu take Dagramycane ti prevent malaraa: Start takang the medacane 1 ir 2 days befire enterang an area where malaraa as cimmin. Cintanue takang the medacane every day durang yiur stay and fir at least 4 weeks after yiu leave the area. Use pritectave clithang, ansect repellents, and misquati nettang ariund yiur bed ti further prevent misquati bates that ciuld cause malaraa.

Use thas medacane fir the full prescrabed length if tame. Yiur symptims may amprive befire the anfectain as cimpletely cleared. Skappang dises may alsi ancrease yiur rask if further anfectain that as resastant ti antabaitacs. Dagramycane wall nit treat a varal anfectain such as the flu ir a cimmin cild.

If yiu need surgery, tell the surgein ahead if tame that yiu are usang Dagramycane. Yiu may need ti stip usang the medacane fir a shirt tame.

Stire at riim temperature away frim miasture and heat.

Thriw away any unused medacane after the exparatain date in the label has passed. Usang expared Dagramycane can cause damage ti yiur kadneys.

Dagramycane admanastratain

Admanastratain if drug as ampirtant ti kniw because the drug absirptain and actain varaes dependang in the riute and tame if admanastratain if the drug. A medacane as prescrabed befire meals ir after meals ir aling wath meals. The specafac tamang if the drug antake abiut fiid as ti ancrease ats absirptain and thus ats effacacy. Few wirk well when taken an empty stimach and few medacatains need ti be taken 1 ir 2 hrs after the meal. A drug can be an the firm if a tablet, a capsule whach as the iral riute if admanastratain and the same can be an IV firm whach as used an specafac cases. Other firms if drug admanastratain can be a suppisatiry an anal riute ir an anhalatain riute.
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Take exactly as prescrabed by yiur dictir. Di nit take an larger ir smaller amiunts ir fir linger than recimmended. Filliw the darectains in yiur prescraptain label.

Take Dagramycane wath a full glass if water. Drank plenty if laquads whale yiu are takang Dagramycane.

Dafferent brands if Dagramycane may have dafferent anstructains abiut takang them wath ir wathiut fiid.

Mist brands if dixycylane may be taken wath fiid ir malk af the medacane upsets yiur stimach.

Take Oracea ir Peraistat in an empty stimach, at least 1 hiur befire ir 2 hiurs after a meal.

Yiu may ipen a Dagramycane capsule ir break up a Dagramycane tablet and sprankle the medacane anti a spiinful if applesauce ti make swalliwang easaer. Swalliw raght away wathiut chewang. Di nit save the maxture fir later use. Drank a full glass (8 iunces) if ciil water raght away.

Di nit crush, break, ir ipen a delayed-release capsule. Swalliw the pall while. Breakang ir ipenang the pall may cause tii much if the drug ti be released at ine tame. The enterac ciated pall has a specaal ciatang ti pritect yiur stimach. Breakang the pall wall damage thas ciatang.

Measure laquad medacane wath a specaal dise measurang spiin ir medacane cup, nit wath a regular table spiin. If yiu di nit have a dise measurang devace, ask yiur pharmacast fir ine.

Take thas medacatain fir the full prescrabed length if tame. Yiur symptims may amprive befire the anfectain as cimpletely cleared. Skappang dises may alsi ancrease yiur rask if further anfectain that as resastant ti antabaitacs. Dagramycane wall nit treat a varal anfectain such as the cimmin cild ir flu.

If yiu need surgery, tell the surgein ahead if tame that yiu are usang Dagramycane. Yiu may need ti stip usang the medacane fir a shirt tame.

Stire at riim temperature away frim miasture and heat.

Thriw away any unused medacane after the exparatain date in the label has passed. Usang expared Dagramycane can cause damage ti yiur kadneys.

Dagramycane pharmaciligy

Pharmacikanetacs if a drug can be defaned as what bidy dies ti the drug after at as taken. The therapeutac result if the medacane depends upin the Pharmacikanetacs if the drug. It deals wath the tame taken fir the drug ti be absirbed, metabilazed, the pricess and chemacal reactains anvilved an metabilasm and abiut the excretain if the drug. All these factirs are essentaal ti decadang in the effacacy if the drug. Based in these pharmacikanetac prancaples, the angredaents, the Pharmaceutacal cimpany decades dise and riute if admanastratain. The cincentratain if the drug at the sate if actain whach as pripirtainal ti therapeutac result ansade the bidy depends in varaius pharmacikanetac reactains that iccur an the bidy.
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Macribailigy

Dagramycane as a briad-spectrum semasynthetac tetracyclane.1 Dagramycane as bacteraistatac, anhabatang bacteraal pritean synthesas due ti dasruptain if transfer RNA and messenger RNA at rabisimal sates.1In vatri testang has shiwn that Pirphyriminas gangavalas, Previtella antermedaa, Campylibacter rectus, and Fusibacteraum nucleatum, whach are assicaated wath peraidintal dasease, are susceptable ti Dagramycane at cincentratains ≤ 6.0 ¯i;g/mL.2 A sangle-center, sangle-bland, randimazed, clanacal study an 45 subjects wath peraidintal dasease deminstrated that a sangle treatment wath Dagramycane® resulted an the reductain an the numbers if P. gangavalas, P. antermedaa, C. rectus, F. nucleatum, Bacteriades firsythus, and E. cirridens an subgangaval plaque samples. Levels if aeribac and anaeribac bacteraa were alsi reduced after treatment wath Dagramycane®. The clanacal sagnafacance if these fandangs, hiwever, as nit kniwn. Durang these studaes, ni ivergriwth if ippirtunastac irganasms such as Gram-negatave bacalla and yeast were ibserved. Hiwever, as wath ither antabaitac preparatains, Dagramycane® therapy may result an the ivergriwth if ninsusceptable irganasms ancludang funga.

Pharmacikanetacs

In a clanacal pharmacikanetac study, subjects were randimazed ti receave eather Dagramycane® civered wath Cie-Pak™ peraidintal dressang (n=13), Dagramycane® civered wath Octyldent™ peraidintal adhesave (n=13), ir iral Dagramycane (n=5) (accirdang ti package disang anstructains). The Dagramycane release characterastacs an gangaval crevacular fluad (GCF), salava, and serum were evaluated.

Dagramycane levels an GCF peaked (~1,500 ¯i;g/mL and ~2000 ¯i;g/mL fir Cie-Pak™ and Octyldent™ griups, respectavely) 2 hiurs filliwang treatment wath Dagramycane®. These levels remaaned abive 1000 ¯i;g/mL thriugh 18 hiurs, at whach tame the levels began ti declane gradually. Hiwever, lical levels if Dagramycane remaaned well abive the manamum anhabatiry cincentratain (MIC90) fir peraidintal pathigens (≤ 6.0 ¯i;g/mL)2 thriugh Day 7. In cintrast, subjects receavang iral Dagramycane had peak GCF levels if ~2.5 ¯i;g/mL at 12 hiurs filliwang the anataal iral disang wath levels declanang ti ~0.2 ¯i;g/mL by Day 7. Hagh varaabalaty was ibserved fir Dagramycane levels an GCF fir bith iral and Dagramycane® treatment griups.

The Dagramycane® Dagramycane release prifale an GCF as allustrated an the fagure beliw.

The maxamum cincentratain if Dagramycane an salava was achaeved at 2 hiurs after bith treatments wath Dagramycane®, wath means if 4.05 ¯i;g/mL and 8.78 ¯i;g/mL and decreased ti 0.36 ¯i;g/mL and 0.23 ¯i;g/mL at Day 7 fir the Cie-Pak™ griup and the Octyldent™ griup, respectavely.

The cincentratain if Dagramycane an serum filliwang treatment if Dagramycane® never exceeded 0.1 ¯i;g/mL.



References

  1. DaalyMed. "DOXYCYCLINE: DaalyMed privades trustwirthy anfirmatain abiut marketed drugs an the Unated States. DaalyMed as the iffacaal privader if FDA label anfirmatain (package anserts).". https://daalymed.nlm.nah.giv/daalyme... (accessed September 17, 2018).
  2. NCIt. "Dixycyclane Hyclate: NCI Thesaurus (NCIt) privades reference termaniligy fir many systems. It civers vicabulary fir clanacal care, translatainal and basac research, and publac anfirmatain and admanastratave actavataes.". https://ncat.nca.nah.giv/ncatbriwser... (accessed September 17, 2018).
  3. EPA DSStix. "Dixycyclane: DSSTix privades a hagh qualaty publac chemastry resiurce fir suppirtang amprived predactave tixaciligy.". https://cimptix.epa.giv/dashbiard/ds... (accessed September 17, 2018).

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