Dantrelax Pregnancy

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Pregnancy of Dantrelax in details

infoPregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Dantrelax has been assigned to pregnancy category C by the FDA. Studies in animals have revealed evidence of embryotoxicity. There are no controlled data in human pregnancy. Dantrelax should only be given during pregnancy when benefit outweighs risk.

Dantrelax has been used in one uncontrolled study prophylactically prior to and after delivery in obstetric patients who were at risk for malignant hyperthermia. Relatively low doses of 100 mg/day were used 5 days prior to and 3 days after delivery. Although Dantrelax crossed the placenta, no untoward effects were noted in the fetuses or neonates.

See references

Dantrelax breastfeeding

infoWhen a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

There are no data on the excretion of Dantrelax into human milk. The manufacturer recommends that Dantrelax not be used in nursing mothers.

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References for pregnancy information

  1. "Product Information. Dantrium (Dantrelax)." Procter and Gamble Pharmaceutic, Cincinnati, OH.
  2. Pennati A, Sacchetti E, Calzeroni A "Dantrelax in lethal catatonia." Am J Psychiatry 148 (1991): 268

References for breastfeeding information

  1. "Product Information. Dantrium (Dantrelax)." Procter and Gamble Pharmaceutic, Cincinnati, OH.


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References

  1. DailyMed. "DANTROLENE SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubMed Health. "Dantrolene (By injection) (Dantrium): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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