Dantrolene Pregnancy

• Pregnancy of Dantrolene in details
• Dantrolene breastfeeding
• Dantrolene reviews

Pregnancy of Dantrolene in details

Dantrolene crosses the human placenta. Cord blood concentrations are similar to those in the maternal plasma at term. and Dantrolene can be detected in the newborn serum at delivery. Adverse events were not observed in the newborn following maternal doses of 100 mg/day administered orally prior to delivery (Shime 1988). Uterine atony has been reported following Dantrolene injection after delivery; however, this may be due in part to the mannitol contained in the IV preparation (Shin 1995; Weingarten 1987). Prophylactic use of Dantrolene is not routinely recommended in pregnant women susceptible to MH prior to obstetric surgery, if use is needed, close monitoring of the mother and newborn is recommended (Krause 2004; Norman 1995).

Dantrolene breastfeeding

There are no data on the excretion of Dantrolene into human milk. The manufacturer recommends that Dantrolene not be used in nursing mothers.

See references

References for pregnancy information

1. "Product Information. Dantrium (Dantrolene)." Procter and Gamble Pharmaceutic, Cincinnati, OH.
2. Pennati A, Sacchetti E, Calzeroni A "Dantrolene in lethal catatonia." Am J Psychiatry 148 (1991): 268

References for breastfeeding information

1. "Product Information. Dantrium (Dantrolene)." Procter and Gamble Pharmaceutic, Cincinnati, OH.

References

1. DailyMed. "DANTROLENE SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubMed Health. "Dantrolene (By injection) (Dantrium): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology