Daraprime Uses

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What is Daraprime?

Daraprime is an antiprotozoal medicine. Antiprotozoals work by killing protozoa (tiny, one-celled animals) or preventing their growth. Some protozoa are parasites that can cause many different kinds of infections in the body.

Daraprime is used with one or more other medicines to treat and prevent malaria and to treat toxoplasmosis. Daraprime may also be used for other problems as determined by your doctor.

Daraprime is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Daraprime is used in certain patients with the following medical conditions:

  • Isosporiasis (treatment and prevention)
  • Pneumocystis carinii pneumonia (treatment)

For patients taking Daraprime for Pneumocystis carinii pneumonia:

  • Daraprime is used in combination with other medicines for mild to moderate pneumonia in patients who cannot take standard treatment.

Daraprime indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.


Acute malaria

Adult: As a single dose, in combination with a sulfonamide: 75 mg Daraprime with 1.5 g sulfadoxine.

Child: 7-13 yr: 50 mg Daraprime with 1 g sulfadoxine; 1-6 yr: 25 mg Daraprime with 500 mg sulfadoxine; 5-11 mth: 12.5 mg Daraprime and 250 mg sulfadoxine. To be taken as a single dose, in combination with a sulfonamide.


Prophylaxis of malaria

Adult: Daraprime 25 mg as single dose once wkly. 1st dose should be taken 1-2 days before arrival in the endemic area, continue admin during stay and for 4-6 wk after leaving the area.

Child: <4 yr: 6.25 mg once wkly; 4-10 yr: 12.5 mg once wkly; >10 yr: 25 mg once wkly. 1st dose should be taken 1-2 days before arrival in the endemic area, continue admin during stay and for 4-6 wk after leaving the area.



Adult: 50-75 mg Daraprime daily with 1-4 g sulfadiazine daily. Continue at this dosage for 1-3 wk, depending on the patient's response and tolerance, then half the dosage and continue for another 4-5 wk.

Child: 1 mg/kg daily 2-4 days then 0.5 mg/kg daily for another 4 wk with usual paediatric dose of sulfadiazine.

How should I use Daraprime?

Use Daraprime as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Daraprime may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Your doctor may also prescribe another medicine called folinic acid (leucovorin calcium) to take along with Daraprime.
  • To clear up your infection completely, continue using Daraprime for the full course of treatment even if you feel better in a few days.
  • If you miss a dose of Daraprime, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Daraprime.

Uses of Daraprime in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This medication is used with other medication (such as a sulfonamide) to treat a serious parasite infection (toxoplasmosis) of the body, brain, or eye or to prevent toxoplasmosis infection in people with HIV infection. Rarely, Daraprime is used with sulfadoxine to treat malaria. The CDC no longer recommends using Daraprime alone to prevent or treat malaria. Daraprime belongs to a class of drugs known as antiparasitics. It works by killing parasites.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This drug may also be used with other medications (such as dapsone) for the prevention and treatment of pneumocystis pneumonia in AIDS patients.

How to use Daraprime

Take this medication by mouth usually once or twice daily or as directed by your doctor. Take this medication with food to decrease nausea and vomiting. If vomiting is severe or continues, your doctor may lower your dose or direct you to stop taking this medication. Your doctor will prescribe another medication (folic/folinic acid) to prevent blood problems caused by Daraprime. Follow your doctor's directions carefully. Drink plenty of fluids to prevent kidney problems if you are taking a "sulfa" medication with Daraprime.

This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug and other antiparasitic drugs regularly, exactly as prescribed by your doctor. To help you remember, take it at the same time(s) each day.

Dosage is based on the type of infection, your medical condition, age, and response to treatment. The length of time you will take this medication depends on your infection. Your dose must be carefully adjusted by your doctor to treat your infection and prevent serious side effects. Follow your doctor's directions carefully.

Do not take more or less of this drug than prescribed. Do not stop taking it before completing this prescription unless directed to do so by your doctor, even if you feel better. Skipping or changing your dose without approval from your doctor may cause the amount of parasites to increase, make the infection more difficult to treat (resistant), or worsen side effects.

Tell your doctor if your condition persists or worsens.

Daraprime description


One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. [PubChem]

Daraprime dosage

For Treatment of Toxoplasmosis: The dosage of Daraprime for the treatment of toxoplasmosis must be carefully adjusted so as to provide maximum therapeutic effect and a minimum of side effects. At the dosage required, there is a marked variation in the tolerance to the drug. Young patients may tolerate higher doses than older individuals. Concurrent administration of folinic acid is strongly recommended in all patients.

The adult starting dose is 50 to 75 mg of the drug daily, together with 1 to 4 g daily of a sulfonamide of the sulfapyrimidine type, e.g. sulfadoxine. This dosage is ordinarily continued for 1 to 3 weeks, depending on the response of the patient and tolerance to therapy. The dosage may then be reduced to about one half that previously given for each drug and continued for an additional 4 to 5 weeks.

The pediatric dosage of Daraprime is 1 mg/kg/day divided into 2 equal daily doses; after 2 to 4 days this dose may be reduced to one half and continued for approximately 1 month. The usual pediatric sulfonamide dosage is used in conjunction with Daraprime.

For Treatment of Acute Malaria

Daraprime is NOT recommended alone in the treatment of acute malaria. Fastacting schizonticides, such as chloroquine or quinine, are indicated for treatment of acute malaria. However, Daraprime at a dosage of 25 mg daily for 2 days with a sulfonamide will initiate transmission control and suppression of non-falciparum malaria. Daraprime is only recommended for patients infected in areas where susceptible plasmodia exist. Should circumstances arise wherein Daraprime must be used alone in semi-immune persons, the adult dosage for acute malaria is 50 mg for 2 days; children 4 through 10 years old may be given 25 mg daily for 2 days. In any event, clinical cure should be followed by the once-weekly regimen described below for chemoprophylaxis. Regimens which include suppression should be extended through any characteristic periods of early recrudescence and late relapse, i.e., for at least 10 weeks in each case.

For Chemoprophylaxis of Malaria

Adults and pediatric patients over 10 years – 25 mg (1 tablet) once weekly

Children 4 through 10 years – 12.5 mg (½ tablet) once weekly

Infants and children under 4 years – 6.25 mg (1/4 tablet) once weekly.

How supplied

White, scored tablets containing 25 mg Daraprime, imprinted with “Daraprime” and “A3A” in bottles of 100 (NDC 52054-330-10 and NDC 52054-330-95).

Store at 15° to 25°C (59° to 77°F) in a dry place and protect from light.

Distributed by: Amedra Pharmaceuticals LLC, Horsham, PA 19044. Revised: October 2014

Daraprime interactions

See also:
What other drugs will affect Daraprime?


Daraprime may be used with sulfonamides, quinine and other antimalarials, and with other antibiotics. However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfon-amides or trimethoprim-sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrex-ate) while the patient is receiving Daraprime, may increase the risk of bone marrow suppression. If signs of folate deficiency develop, Daraprime should be discontinued. Folinic acid (leucovorin) should be administered until normal hematopoiesis is restored. Mild hepatotoxicity has been reported in some patients when lorazepam and Daraprime were administered concomitantly.

Daraprime side effects

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What are the possible side effects of Daraprime?

Applies to Daraprime: oral tablet

In addition to its needed effects, some unwanted effects may be caused by Daraprime (the active ingredient contained in Daraprime). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Daraprime:

Less common:

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • irritation or soreness of tongue
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising
  • Bleeding or crusting sores on lips
  • chest pain or discomfort
  • muscle cramps or pain
  • redness, blistering, peeling, or loosening of skin
  • skin rash
  • sores, ulcers, and/or white spots in mouth
  • sore throat
  • unusual tiredness or weakness
Frequency not known
  • Blood in urine
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fainting spells
  • fast, slow, or irregular heartbeat
  • hives
  • itching
  • joint or muscle pain
  • lightheadedness
  • pale skin
  • pounding or rapid pulse
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rapid breathing
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • shortness of breath
  • swollen glands
  • tightness in chest
  • unexplained bleeding or bruising
  • wheezing
Symptoms of overdose:
  • Abdominal or stomach pain
  • convulsions (seizures)
  • increased excitability
  • vomiting (severe and continuing)

Minor Side Effects

Some of the side effects that can occur with Daraprime may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

  • Diarrhea
  • loss of appetite
  • nausea
  • vomiting

Daraprime contraindications

See also:
What is the most important information I should know about Daraprime?

Stop taking Daraprime and seek medical attention at the first sign of a skin rash, sore throat, paleness of the skin, unusual bruising under the skin, or swelling of the tongue. These may be early symptoms of serious side effects of Daraprime.

Daraprime may cause stomach upset or vomiting. Take each dose with food to lessen this side effect.

Active ingredient matches for Daraprime:


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Pyrimethamine 25 mg

List of Daraprime substitutes (brand and generic names):

Falcipar 500+25 Tablet (Synmedic Laboratories)$ 0.04
G Kelfin 500+25 Tablet (Shrinivas (Gujarat) Laboratories Pvt. Ltd.)$ 0.05
G KELFIN 25MG/500MG TABLET 1 strip / 2 tablets each (Shrinivas (Gujarat) Laboratories Pvt. Ltd.)$ 0.11
G Kelfin 25 mg/500 mg Tablet (Shrinivas (Gujarat) Laboratories Pvt. Ltd.)$ 0.06
Hikelf 500+25 Tablet (Hinglaj Laboratories of India)$ 0.10
Kelfin 500+25 Tablet (Norwest Pharmaceuticals Inc.)$ 0.06
Tablet; Oral; Pyrimethamine 50 mg (Malody)
Malocid Dried aluminium hydroxide 250mg, simeticone 25 mg, magnesium hydroxide 250 mg/5mL. O-SUSP / 170ml (Malody)
MALOCID oral susp 170ml (Malody)
Tablet; Oral; Pyrimethamine 50 mg (Torrent)
MALOCIDE Capsule/ Tablet / 25mg - 500mg / 2 units (Torrent)$ 0.04
Malocide Pyrimethamine 25mg, Sulfadoxine 500mg TAB / 2 (Torrent)$ 0.05
2's (Torrent)$ 0.05
MALOCIDE INJECTION 1 vial / 2 ML injection each (Torrent)$ 3.02
MALOCIDE TABLET 1 strip / 4 tablets each (Torrent)$ 1.59
MALOCIDE tab 2's (Torrent)$ 0.05
Malocide Injection (Torrent)$ 1.51
Malocide Tablet (Torrent)$ 0.40
Onli 2 25+500 Tablet (Kopran Pharma Ltd)$ 0.03
Pyrimethamine powder$ 8.88
Daraprim 25 mg tablet$ 0.98
Pyrimethamine powder$ 8.88
Daraprim 25 mg tablet$ 0.98
Pyrimethamine powder$ 8.88
Daraprim 25 mg tablet$ 0.98
Pyrimethamine powder$ 8.88
Daraprim 25 mg tablet$ 0.98
Pyrisone 500's (Beacons)
2's (Shreya)$ 0.08
Rezkid Pyrimethamine 18.75mg, Sulfadoxine 375mg TAB / 2 (Shreya)$ 0.08
REZKID tab 2's (Shreya)$ 0.08


  1. DailyMed. "PYRIMETHAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "pyrimethamine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "pyrimethamine". http://www.drugbank.ca/drugs/DB00205 (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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