Description: Deflax, derived from prednisolone, is a corticosteroid with mainly glucocorticoid activity. An anti-inflammatory dose of 6 mg Deflax is equiv to 5 mg prednisolone.
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
You may take Deflax with or without food.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
To make swallowing easier, you may crush the Deflax tablet and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.
Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine using only the dosing syringe provided. If you do not have this dosing syringe, ask your pharmacist for one.
To improve the flavor of Deflax liquid, you may mix your measured dose with 3 to 4 ounces of milk or fruit juice (but not grapefruit juice). Drink this mixture right away and do not save it for later.
Deflax can lower blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. Serious and sometimes fatal infections may occur during treatment with Deflax.
Call your doctor if you have signs of infection (fever, chills, body aches, sweating, mouth sores, skin sores, warmth or redness, vomiting, diarrhea, painful urination).
If you use this medicine long-term, you may need frequent blood tests. Your blood pressure, vision, and bone density may also need to be checked.
Tell your doctor if you have any changes in weight. Deflax doses are based on weight, and any changes may affect the dose.
If you need surgery, tell the surgeon ahead of time that you are using Deflax.
You should not stop using Deflax suddenly. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture and heat.
Throw away any Deflax liquid that has not been used within 1 month after you first opened the bottle.
Tablets: Administer whole or may crush and mix with applesauce (administer applesauce mixture immediately).
Suspension: Shake well; measure prescribed dose with provided dispenser, mix thoroughly with 3 to 4 ounces of juice or milk and administer immediately. Do not mix or administer with grapefruit juice.
Deflax is a corticosteroid prodrug; its active metabolite, 21-desDFZ, acts on the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects. The precise mechanism by which Deflax exerts its therapeutic effects in patients with Duchenne muscular dystrophy is unknown.
Rapidly converted by esterases to 21-desDFZ (active metabolite); 21-desDFZ metabolized by CYP3A4 to several metabolites (inactive)
Urine (~68%; 18% as 21-desDFZ)
1 hour (range: 0.25 to 2 hours); delayed by 1 hour with a high-fat meal
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Information checked by Dr. Sachin Kumar, MD Pharmacology