Actions of Deflazacort Leti in details
Description: Deflazacort Leti, derived from prednisolone, is a corticosteroid with mainly glucocorticoid activity. An anti-inflammatory dose of 6 mg Deflazacort Leti is equiv to 5 mg prednisolone.
How should I take Deflazacort Leti?
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
You may take Deflazacort Leti with or without food.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
To make swallowing easier, you may crush the Deflazacort Leti tablet and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.
Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine using only the dosing syringe provided. If you do not have this dosing syringe, ask your pharmacist for one.
To improve the flavor of Deflazacort Leti liquid, you may mix your measured dose with 3 to 4 ounces of milk or fruit juice (but not grapefruit juice). Drink this mixture right away and do not save it for later.
Deflazacort Leti can lower blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. Serious and sometimes fatal infections may occur during treatment with Deflazacort Leti.
Call your doctor if you have signs of infection (fever, chills, body aches, sweating, mouth sores, skin sores, warmth or redness, vomiting, diarrhea, painful urination).
If you use this medicine long-term, you may need frequent blood tests. Your blood pressure, vision, and bone density may also need to be checked.
Tell your doctor if you have any changes in weight. Deflazacort Leti doses are based on weight, and any changes may affect the dose.
If you need surgery, tell the surgeon ahead of time that you are using Deflazacort Leti.
You should not stop using Deflazacort Leti suddenly. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture and heat.
Throw away any Deflazacort Leti liquid that has not been used within 1 month after you first opened the bottle.
Deflazacort Leti administration
Oral: Administer with or without food.
Tablets: Administer whole or may crush and mix with applesauce (administer applesauce mixture immediately).
Suspension: Shake well; measure prescribed dose with provided dispenser, mix thoroughly with 3 to 4 ounces of juice or milk and administer immediately. Do not mix or administer with grapefruit juice.
Deflazacort Leti pharmacology
Deflazacort Leti is a corticosteroid prodrug; its active metabolite, 21-desDFZ, acts on the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects. The precise mechanism by which Deflazacort Leti exerts its therapeutic effects in patients with Duchenne muscular dystrophy is unknown.
Metabolism
Rapidly converted by esterases to 21-desDFZ (active metabolite); 21-desDFZ metabolized by CYP3A4 to several metabolites (inactive)
Excretion
Urine (~68%; 18% as 21-desDFZ)
Time to Peak
1 hour (range: 0.25 to 2 hours); delayed by 1 hour with a high-fat meal
Protein Binding
~40%
References
- DailyMed. "DEFLAZACORT: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- EPA DSStox. "Deflazacort: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Deflazacort Leti are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Deflazacort Leti. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported administration
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
