Deline Uses

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What is Deline?

Deline is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Deline is used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose. It is also used to treat skin hives and itching in people with chronic skin reactions.

Deline may also be used for purposes not listed in this medication guide.

Deline indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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1.1 Seasonal Allergic Rhinitis

Deline Tablets are indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 12 years of age and older.

1.2 Perennial Allergic Rhinitis

Deline Tablets are indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 12 years of age and older.

1.3 Chronic Idiopathic Urticaria

Deline Tablets are indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 12 years of age and older.

How should I use Deline?

Use Deline orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Deline orally disintegrating tablets.

Uses of Deline in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Allergic rhinitis: Relief of nasal and non-nasal symptoms of seasonal (SAR) and perennial (PAR) allergic rhinitis

Urticaria: Symptomatic relief of pruritus, reduction in number of hives, and reduction in size of hives associated with chronic idiopathic urticaria (CIU)

Off Label Uses

NSAID-associated urticaria (prophylaxis)

Data from a retrospective study with a limited number of patients suggest that Deline may be beneficial for prophylactic therapy in patients with NSAID-associated urticaria prior to receiving a strong COX-1 inhibitor. Additional trials may be needed to further define the role of Deline in this setting.

Deline description

Deline Tab: Each tablet contains 5.0 mg of Deline.

Deline Syr: Each mL of Deline syrup contains 500 mcg of Deline.

Excipients/Inactive Ingredients: Deline Tab: Dibasic calcium phosphate dihydrate, microcrystalline cellulose, maize starch, talc, blue color film-coat material, clear film coat material, white wax and carnauba wax.

Deline dosage

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Deline Dosage

Generic name: Deline 5mg

Dosage form: tablet, film coated; oral solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Although an orally disintegrating tablet formulation of Deline may be available in the marketplace, Deline® RediTabs® Tablets are no longer marketed.

Deline Tablets,

Oral Solution, or RediTabs Tablets may be taken without regard to meals. Place Deline (Deline) RediTabs Tablets on the tongue and allow to disintegrate before swallowing. Tablet disintegration occurs rapidly. Administer with or without water. Take tablet immediately after opening the blister.

The age-appropriate dose of Deline

Oral Solution should be administered with a commercially available measuring dropper or syringe that is calibrated to deliver 2 mL and 2.5 mL (½ teaspoon).

Adults and Adolescents 12 Years of Age and Over

The recommended dose of Deline Tablets or Deline Tablets is one 5-mg tablet once daily. The recommended dose of Deline

Oral Solution is 2 teaspoonfuls (5 mg in 10 mL) once daily.

Children 6 to 11 Years of Age

The recommended dose of Deline

Oral Solution is 1 teaspoonful (2.5 mg in 5 mL) once daily. The recommended dose of Deline Tablets is one 2.5-mg tablet once daily.

Children 12 Months to 5 Years of Age

The recommended dose of Deline

Oral Solution is ½ teaspoonful (1.25 mg in 2.5 mL) once daily.

Children 6 to 11 Months of Age

The recommended dose of Deline

Oral Solution is 2 mL (1 mg) once daily.

Adults with Hepatic or Renal Impairment

In adult patients with liver or renal impairment, a starting dose of one 5-mg tablet every other day is recommended based on pharmacokinetic data. Dosing recommendation for children with liver or renal impairment cannot be made due to lack of data.

More about Deline (Deline)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Deline interactions

See also:
What other drugs will affect Deline?

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Inhibitors Of Cytochrome P450 3A4

In controlled clinical studies co-administration of Deline with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of Deline and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Deline.

Fluoxetine

In controlled clinical studies co-administration of Deline with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of Deline and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Deline.

Cimetidine

In controlled clinical studies co-administration of Deline with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of Deline and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Deline.

Drug Abuse And Dependence

There is no information to indicate that abuse or dependency occurs with Deline Tablets.

Deline side effects

See also:
What are the possible side effects of Deline?

The following adverse reactions are discussed in greater detail in other sections of the label:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

Adults and Adolescents

Allergic Rhinitis: In multiple-dose placebo-controlled trials, 2834 patients ages 12 years or older received Deline tablets at doses of 2.5 mg to 20 mg daily, of whom 1655 patients received the recommended daily dose of 5 mg. In patients receiving 5 mg daily, the rate of adverse events was similar between Deline and placebo-treated patients. The percent of patients who withdrew prematurely due to adverse events was 2.4% in the Deline group and 2.6% in the placebo group. There were no serious adverse events in these trials in patients receiving Deline. All adverse events that were reported by greater than or equal to 2% of patients who received the recommended daily dose of Deline tablets (5 mg once daily), and that were more common with Deline tablets than placebo, are listed in Table 1.

The frequency and magnitude of laboratory and electrocardiographic abnormalities were similar in Deline and placebo-treated patients.

There were no differences in adverse events for subgroups of patients as defined by gender, age, or race.

Chronic Idiopathic Urticaria: In multiple-dose, placebo-controlled trials of chronic idiopathic urticaria, 211 patients ages 12 years or older received Deline tablets and 205 received placebo. Adverse events that were reported by greater than or equal to 2% of patients who received Deline tablets and that were more common with Deline than placebo were (rates for Deline and placebo, respectively): headache (14%, 13%), nausea (5%, 2%), fatigue (5%, 1%), dizziness (4%, 3%), pharyngitis (3%, 2%), dyspepsia (3%, 1%), and myalgia (3%, 1%).

Pediatrics

Two hundred and forty-six pediatric subjects 6 months to 11 years of age received Deline

Oral Solution for 15 days in three placebo-controlled clinical trials. Pediatric subjects aged 6 to 11 years received 2.5 mg once a day, subjects aged 1 to 5 years received 1.25 mg once a day, and subjects 6 to 11 months of age received 1.0 mg once a day.

In subjects 6 to 11 years of age, no individual adverse event was reported by 2 percent or more of the subjects.

In subjects 2 to 5 years of age, adverse events reported for Deline and placebo in at least 2 percent of subjects receiving Deline

Oral Solution and at a frequency greater than placebo were fever (5.5%, 5.4%), urinary tract infection (3.6%, 0%) and varicella (3.6%, 0%).

In subjects 12 months to 23 months of age, adverse events reported for the Deline product and placebo in at least 2 percent of subjects receiving Deline

Oral Solution and at a frequency greater than placebo were fever (16.9%, 12.9%), diarrhea (15.4%, 11.3%), upper respiratory tract infections (10.8%, 9.7%), coughing (10.8%, 6.5%), appetite increased (3.1%, 1.6%), emotional lability (3.1%, 0%), epistaxis (3.1%, 0%), parasitic infection (3.1%, 0%), pharyngitis (3.1%, 0%), rash maculopapular (3.1%, 0%).

In subjects 6 months to 11 months of age, adverse events reported for Deline and placebo in at least 2 percent of subjects receiving Deline

Oral Solution and at a frequency greater than placebo were upper respiratory tract infections (21.2%, 12.9%), diarrhea (19.7%, 8.1%), fever (12.1%, 1.6%), irritability (12.1%, 11.3%), coughing (10.6%, 9.7%), somnolence (9.1%, 8.1%), bronchitis (6.1%, 0%), otitis media (6.1%, 1.6%), vomiting (6.1%, 3.2%), anorexia (4.5%, 1.6%), pharyngitis (4.5%, 1.6%), insomnia (4.5%, 0%), rhinorrhea (4.5%, 3.2%), erythema (3.0%, 1.6%), and nausea (3.0%, 0%).

There were no clinically meaningful changes in any electrocardiographic parameter, including the QTc interval. Only one of the 246 pediatric subjects receiving Deline

Oral Solution in the clinical trials discontinued treatment because of an adverse event.

Post-Marketing Experience

Because adverse events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The following spontaneous adverse events have been reported during the marketing of Deline: tachycardia, palpitations, rare cases of hypersensitivity reactions (such as rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis), psychomotor hyperactivity, movement disorders (including dystonia, tics, and extrapyramidal symptoms), seizures, and elevated liver enzymes including bilirubin, and very rarely, hepatitis.

Deline contraindications

See also:
What is the most important information I should know about Deline?

You should not take this medication if you are allergic to Deline or to loratadine (Claritin).

Before taking Deline, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

Do not give this medication to a child younger than 2 years old without the advice of a doctor.

Deline disintegrating tablets (Deline) may contain phenylalanine. Talk to your doctor before using this form of Deline if you have phenylketonuria (PKU).

Active ingredient matches for Deline:

Desloratadine in Lebanon.

Doxycycline

Doxycycline/lactobacillus in India.


Unit description / dosage (Manufacturer)Price, USD
Deline 100 mg Capsule$ 0.03
DELINE 100MG CAPSULE 1 strip / 10 capsules each (Alde Medi Impex Ltd)$ 0.28
DELINE cap 10's (Alde Medi)
Deline 100mg Capsule (Alde Medi Impex Ltd)$ 0.03

List of Deline substitutes (brand and generic names):

Delopa 5 mg x 10 Blister x 10 Tablet
Delopedil 5 mg x 1 Blister 10 Tablet
DELORID TABLET 1 strip / 10 tablets each (Zyris Derma Care (P) Ltd)$ 0.53
DELORTA Capsule/ Tablet / 5mg / 10 units (Abbott Healthcare Pvt Ltd (AHPL))$ 0.68
5 mg x 10's (Abbott Healthcare Pvt Ltd (AHPL))$ 0.63
Delorta 5mg TAB / 10 (Abbott Healthcare Pvt Ltd (AHPL))$ 0.63
Delorta 5 mg Tablet (Abbott Healthcare Pvt Ltd (AHPL))$ 0.06
DELORTA tab 5 mg x 10's (Abbott Healthcare Pvt Ltd (AHPL))$ 0.63
Delorta 5mg TAB / 10 (Abbott Healthcare Pvt Ltd (AHPL))$ 0.63
Delotid 5mg TAB / 10 (DWD)
5 mg x 10's (DWD)
DELOTID tab 5 mg x 10's (DWD)$ 0.66
Denosin 5 mg x 50 x 10's
Denosin 20 mg x 10 Blister x 10 Tablet
Tablet, Film-Coated; Oral; Doxycycline 20 mg
Tablets, Film-Coated; Oral; Doxycycline 20 mg
DES - OD Capsule/ Tablet / 5mg / 10 units (Cadila Pharmaceuticals (Le Sante Division))$ 0.65
Des OD 5 mg x 10 Blister x 10 Tablet (Le Sante (Cadila Pharmaceuticals Ltd.))
Des OD 5 mg Tablet (Le Sante (Cadila Pharmaceuticals Ltd.))$ 0.07
DES OD 10 MG TABLET 1 strip / 10 tablets each (Le Sante (Cadila Pharmaceuticals Ltd.))$ 0.79
Des OD 10mg Tablet (Le Sante (Cadila Pharmaceuticals Ltd.))$ 0.09

References

  1. DailyMed. "DOXYCYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "DESLORATADINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "doxycycline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Deline are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Deline. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Deline drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Not useful1
100.0%


1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Deline drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Not expensive1
100.0%


Consumer reported time for results

No survey data has been collected yet


1 consumer reported age

Users%
1-51
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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