Consists of Dequalinium Chloride, Lidocaine Hcl
Dosage of Dequalinium Chloride in details
Usual Dose: One (1) vaginal tablet daily for 6 days.
Administration: If the effect of Dequalinium Chloride is too strong or too weak, inform a physician or pharmacist.
Dequalinium Chloride contains excipients which do not dissolve completely, such that remains of the tablet are occasionally found in the panties. This is of no importance for the efficacy of Dequalinium Chloride.
In rare cases of a very dry vagina, it is possible that the vaginal tablet does not dissolve and is discharged by the vagina as intact tablet. As consequence, the treatment is not optimal. However, this is not harmful to the vagina. For prevention, the vaginal tablet can be moistened with a little tap water before insertion into a very dry vagina.
Use a sanitary towel or panty liner. There is no change in colour of the underwear.
Change underwear and flannel daily and launder them at a temperature of at least 80°C.
Missed Dose: Do not take a double dose to make up for the forgotten individual doses. Continue with use of 1 vaginal tablet daily.
Discontinuation of Treatment: A treatment of <6 days may result in a relapse. The discomfort may disappear often before the infection is completely cured. Therefore, do not stop treatment early, even when there is no discomfort (eg, itching, discharge, smell) anymore.
Insert the vaginal tablet deeply into the vagina in the evening before retiring. This is best performed in a reclining position with the legs slightly bent.
The treatment should be interrupted during menstruation and continued when menses is ceased.
Dequalinium Chloride interactions
No interactions are known.
Patients should be advised to inform a physician or pharmacist if they are taking or have recently taken any other medicines even those not prescribed.
Incompatibilities: Dequalinium Chloride is incompatible with soaps and other anionic surfactants, with phenol and with chlorocresol.
Dosage of Lidocaine Hcl in details
When 4% Xylocaine-MPF Sterile Solution is used concomitantly with other products containing lidocaine, the total dose contributed by all formulations must be kept in mind.
The dosage varies and depends upon the area to be anesthetized, vascularity of the tissues, individual tolerance and the technique of anesthesia. The lowest dosage needed to provide effective anesthesia should be administered. Dosages should be reduced for children and for elderly and debilitated patients.
Although the incidence of adverse effects with 4% Xylocaine-MPF Sterile Solution is quite low, caution should be exercised, particularly when employing large volumes and concentrations of 4% Xylocaine-MPF Sterile Solution since the incidence of adverse effects is directly proportional to the total dose of local anesthetic agent administered. For specific techniques and procedures refer to standard textbooks.
There have been adverse event reports of chondrolysis in patients receiving intra-articular infusions of local anesthetics following arthroscopic and other surgical procedures. 4% Xylocaine-MPF is not approved for this use.
The dosages below are for normal, healthy adults.
RETROBULBAR INJECTION: The suggested dose for a 70 kg person is 3-5 mL (120200 mg of lidocaine HCl), ie, 1.7-3 mg/kg or 0.9-1.5 mg/lb body weight. A portion of this is injected retrobulbarly and the rest may be used to block the facial nerve.
TRANSTRACHEAL INJECTION: For local anesthesia by the transtracheal route 2-3 mL should be injected through a large enough needle so that the injection can be made rapidly. By injecting during inspiration some of the drug will be carried into the bronchi and the resulting cough will distribute the rest of the drug over the vocal cords and the epiglottis.
Occasionally it may be necessary to spray the pharynx by oropharyngeal spray to achieve complete analgesia. For the combination of the injection and spray, it should rarely be necessary to utilize more than 5 mL (200 mg of lidocaine HCl), ie, 3 mg/kg or 1.5 mg/lb body weight.
TOPICAL APPLICATION: For laryngoscopy, bronchoscopy and endotracheal intubation, the pharynx may be sprayed with 1-5 mL (40-200 mg of lidocaine HCl), ie, 0.6-3 mg/kg or 0.3-1.5 mg/lb body weight.
Maximum Recommended Dosages
Normal Healthy Adults: The maximum recommended dose of 4% Xylocaine-MPF Sterile Solution should be such that the dose of lidocaine HCl is kept below 300 mg and in any case should not exceed 4.5 mg/kg (2 mg/lb) body weight.
Children
It is difficult to recommend a maximum dose of any drug for children since this varies as a function of age and weight. For children of less than ten years who have a normal lean body mass and normal body development, the maximum dose may be determined by the application of one of the standard pediatric drug formulas (eg, Clark's rule). For example, in a child of five years weighing 50 lbs., the dose of lidocaine hydrochloride should not exceed 75-100 mg when calculated according to Clark's rule. In any case, the maximum dose of Xylocaine Solution with epinephrine should not exceed 7 mg/kg (3.2 mg/lb) of body weight. When used without epinephrine, the amount of Xylocaine Solution administered should be such that the dose of lidocaine is kept below 300 mg and in any case should not exceed 4.5 mg/kg (2 mg/lb) of body weight.
NOTE:
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever the solution and container permit. Solutions that are discolored and/or contain particulate matter should not be used.
How supplied
4% Xylocaine-MPF (lidocaine HCl) Sterile Solution, 5 mL ampule.
| Product No. | NDC No. | Strength | |
| 491089 | 63323-490-89 | 4% | 5mL ampule packaged in tens. |
Store at 20° to 25°C (68° to 77°F).
Manufactured for: APP Pharmaceuticals, LLC, Schaumburg, IL 6017. Revised: February 2010
What other drugs will affect Lidocaine Hcl?
There may be other drugs that can interact with lidocaine injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Lidocaine Hcl interactions
Anti-Arrhythmic Drugs: Local anaesthetics of the amide type, such as lignocaine, should be used with caution in patients receiving other local anaesthetics or agents structurally related to amide-type local anaesthetics e.g. certain anti-arrhythmic drugs such as disopyramide, procainamide, mexilitene since potentiation of cardiac effects may occur. Specific interaction studies with lignocaine and anti-arrhythmic drugs class III (eg amiodarone) have not been performed, but caution should be advised.
Amiodarone: Amiodarone has been reported to reduce the clearance of lignocaine in two case reports, although a small prospective study of combined therapy on lignocaine pharmacokinetics found no change in clearance or other pharmacokinetic factor. This combination has been reported to precipitate seizures and to lead to severe sinus bradycardia and a long sinoatrial arrest. Until more experience with concurrent use of lignocaine and amiodarone becomes available, patients receiving the combination should be monitored carefully.
Beta-Adrenoreceptor Antagonists: Propranolol and metoprolol reduce the metabolism of IV administered lignocaine and the possibility of this effect with other beta-adrenergic blockers should be kept in mind. If these drugs are administered concurrently, the patient should be closely observed for signs of lignocaine toxicity.
Cimetidine: Cimetidine reduces the clearance of IV administered lignocaine and toxic effects due to high serum lignocaine levels have been reported when these two drugs have been administered concurrently.
Anticonvulsive Agents: Phenytoin and other antiepileptic drugs such as phenobarbitone, primidone and carbamazepine appear to enhance the metabolism of lignocaine but the significance of this effect is not known. Phenytoin and lignocaine have additive cardiac depressant effects.
Inhalational Anaesthetics: Lignocaine decreases the minimum effective concentration of inhalational anaesthetics such as nitrous oxide.
Skeletal Muscle Relaxants: Lignocaine and skeletal muscle relaxants, e.g. suxamethonium, lead to excessive neuromuscular blockade; therefore this combination must be used with caution.
Structurally Related Local Anaesthetics: Lignocaine should be used with caution in patients receiving agents structurally related to local anaesthetics.
Alkaline Solutions: The solubility of lignocaine is limited at pH values above 7.0. This must be taken into consideration if adding an alkaline solution since precipitation might occur at higher pH values.
Laboratory Test Effects: Creatinine: Creatinine measurements in patients with therapeutic plasma levels of lignocaine are about 15-35% higher when measured by an enzymatic method versus the Jaffe method. This appears to be due to assay interference from N-ethylglycine, a metabolite of lignocaine.
Creatine Kinase: The intramuscular injection of lignocaine may result in an increase in creatine kinase levels for up to 48 hrs. This may interfere with the diagnosis of myocardial infarction.
References
- DailyMed. "LIDOCAINE; TETRACAINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "E7QC7V26B8: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Dequalinium Chloride/Lidocaine Hcl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dequalinium Chloride/Lidocaine Hcl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
