• Dosage of Dertin in details
• Dertin interactions
• Dertin reviews

Dosage of Dertin in details

Dertin Dosage

Applies to the following strength(s): 5 mg; 10 mg; 25 mg; 100 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Anxiety
• Light Sedation
• Alcohol Withdrawal

Usual Geriatric Dose for:

• Anxiety

Usual Pediatric Dose for:

• Anxiety

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Precautions
• Dialysis
• Other Comments

Usual Adult Dose for Anxiety

Mild to moderate anxiety: 5 or 10 mg orally, 3 or 4 times per day

Severe anxiety: 20 or 25 mg orally, 3 or 4 times per day

Use: Relief of mild, moderate, and severe anxiety disorders

Usual Adult Dose for Light Sedation

On days preceding surgery, 5 to 10 mg orally, 3 or 4 times per day

Use: Relief of preoperative apprehension and anxiety

Usual Adult Dose for Alcohol Withdrawal

50 to 100 mg orally, followed by repeated doses as needed until agitation is controlled

Maximum dose: 300 mg orally per day

Use: Relief of withdrawal symptoms of acute alcoholism

Usual Geriatric Dose for Anxiety

Elderly or debilitated patients:

5 mg orally, 2 to 4 times per day

Use: Relief of mild, moderate, and severe anxiety disorders

Usual Pediatric Dose for Anxiety

6 years or older:

5 mg orally, 2 to 4 times per day; this may be increased to 10 mg orally, 2 to 3 times per day

Use: Relief of mild, moderate, and severe anxiety disorders

Renal Dose Adjustments

Renal impairment: Use with caution

Liver Dose Adjustments

Hepatic impairment: Use with caution

Precautions

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Storage requirements:

-Protect from light

Monitoring:

-Psychiatric: Patients with a history of alcohol or drug abuse, or patients with a marked personality disorder should be monitored frequently.

Patient advice:

-Patients should be cautioned against performing activities requiring complete mental alertness, such as operating machinery or driving a motor vehicle.

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What other drugs will affect Dertin?

Before taking Dertin, tell your doctor if you are using any of the following drugs:

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);

• a blood thinner such as warfarin (Coumadin); or

• an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);

• medicine to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);

• narcotic medication such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or

• an antidepressant such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).

This is not a complete list and there may be other drugs that can interact with Dertin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Dertin interactions

When this drug applied simultaneously with:

- antipsychotic drugs (neuroleptics), antidepressants, sedatives, hypnotics, anesthetics, analgesics, ethanol enhanced the inhibitory effect on central nervous system, especially when administered parenterally.

- concomitant use of antacids can delay but not reduce the absorption of Dertin.

- hormonal contraceptives increases the effectiveness of Dertin.

- with muscle relaxants may enhance the action of muscle relaxants, with levodopa - may suppress antiparkinsonian action.

- theophylline at low doses perverts sedative effect of Dertin.

- phenobarbital and phenytoin may accelerate the metabolism of Dertin. In rare cases this medication inhibits the metabolism and enhances the action of phenytoin.

- may increase the toxicity of cyclophosphamide.

- cimetidine, omeprazole, disulfiram may increase the intensity and duration of action of this medicine.

References

1. DailyMed. "AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. FDA/SPL Indexing Data. "6RZ6XEZ3CR: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
3. MeSH. "Hypnotics and Sedatives". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology