Des Uses

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What is Des?

Des is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Des is used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose. It is also used to treat skin hives and itching in people with chronic skin reactions.

Des may also be used for purposes not listed in this medication guide.

Des indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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1.1 Seasonal Allergic Rhinitis

Des Tablets are indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 12 years of age and older.

1.2 Perennial Allergic Rhinitis

Des Tablets are indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 12 years of age and older.

1.3 Chronic Idiopathic Urticaria

Des Tablets are indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 12 years of age and older.

How should I use Des?

Use Des orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Des orally disintegrating tablets.

Uses of Des in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Allergic rhinitis: Relief of nasal and non-nasal symptoms of seasonal (SAR) and perennial (PAR) allergic rhinitis

Urticaria: Symptomatic relief of pruritus, reduction in number of hives, and reduction in size of hives associated with chronic idiopathic urticaria (CIU)

Off Label Uses

NSAID-associated urticaria (prophylaxis)

Data from a retrospective study with a limited number of patients suggest that Des may be beneficial for prophylactic therapy in patients with NSAID-associated urticaria prior to receiving a strong COX-1 inhibitor. Additional trials may be needed to further define the role of Des in this setting.

Des description

Des Tab: Each tablet contains 5.0 mg of Des.

Des Syr: Each mL of Des syrup contains 500 mcg of Des.

Excipients/Inactive Ingredients: Des Tab: Dibasic calcium phosphate dihydrate, microcrystalline cellulose, maize starch, talc, blue color film-coat material, clear film coat material, white wax and carnauba wax.

Des dosage

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Des Dosage

Generic name: Des 5mg

Dosage form: tablet, film coated; oral solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Although an orally disintegrating tablet formulation of Des may be available in the marketplace, Des® RediTabs® Tablets are no longer marketed.

Des Tablets,

Oral Solution, or RediTabs Tablets may be taken without regard to meals. Place Des (Des) RediTabs Tablets on the tongue and allow to disintegrate before swallowing. Tablet disintegration occurs rapidly. Administer with or without water. Take tablet immediately after opening the blister.

The age-appropriate dose of Des

Oral Solution should be administered with a commercially available measuring dropper or syringe that is calibrated to deliver 2 mL and 2.5 mL (½ teaspoon).

Adults and Adolescents 12 Years of Age and Over

The recommended dose of Des Tablets or Des Tablets is one 5-mg tablet once daily. The recommended dose of Des

Oral Solution is 2 teaspoonfuls (5 mg in 10 mL) once daily.

Children 6 to 11 Years of Age

The recommended dose of Des

Oral Solution is 1 teaspoonful (2.5 mg in 5 mL) once daily. The recommended dose of Des Tablets is one 2.5-mg tablet once daily.

Children 12 Months to 5 Years of Age

The recommended dose of Des

Oral Solution is ½ teaspoonful (1.25 mg in 2.5 mL) once daily.

Children 6 to 11 Months of Age

The recommended dose of Des

Oral Solution is 2 mL (1 mg) once daily.

Adults with Hepatic or Renal Impairment

In adult patients with liver or renal impairment, a starting dose of one 5-mg tablet every other day is recommended based on pharmacokinetic data. Dosing recommendation for children with liver or renal impairment cannot be made due to lack of data.

More about Des (Des)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Des interactions

See also:
What other drugs will affect Des?

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Inhibitors Of Cytochrome P450 3A4

In controlled clinical studies co-administration of Des with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of Des and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Des.

Fluoxetine

In controlled clinical studies co-administration of Des with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of Des and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Des.

Cimetidine

In controlled clinical studies co-administration of Des with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of Des and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Des.

Drug Abuse And Dependence

There is no information to indicate that abuse or dependency occurs with Des Tablets.

Des side effects

See also:
What are the possible side effects of Des?

The following adverse reactions are discussed in greater detail in other sections of the label:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

Adults and Adolescents

Allergic Rhinitis: In multiple-dose placebo-controlled trials, 2834 patients ages 12 years or older received Des tablets at doses of 2.5 mg to 20 mg daily, of whom 1655 patients received the recommended daily dose of 5 mg. In patients receiving 5 mg daily, the rate of adverse events was similar between Des and placebo-treated patients. The percent of patients who withdrew prematurely due to adverse events was 2.4% in the Des group and 2.6% in the placebo group. There were no serious adverse events in these trials in patients receiving Des. All adverse events that were reported by greater than or equal to 2% of patients who received the recommended daily dose of Des tablets (5 mg once daily), and that were more common with Des tablets than placebo, are listed in Table 1.

The frequency and magnitude of laboratory and electrocardiographic abnormalities were similar in Des and placebo-treated patients.

There were no differences in adverse events for subgroups of patients as defined by gender, age, or race.

Chronic Idiopathic Urticaria: In multiple-dose, placebo-controlled trials of chronic idiopathic urticaria, 211 patients ages 12 years or older received Des tablets and 205 received placebo. Adverse events that were reported by greater than or equal to 2% of patients who received Des tablets and that were more common with Des than placebo were (rates for Des and placebo, respectively): headache (14%, 13%), nausea (5%, 2%), fatigue (5%, 1%), dizziness (4%, 3%), pharyngitis (3%, 2%), dyspepsia (3%, 1%), and myalgia (3%, 1%).

Pediatrics

Two hundred and forty-six pediatric subjects 6 months to 11 years of age received Des

Oral Solution for 15 days in three placebo-controlled clinical trials. Pediatric subjects aged 6 to 11 years received 2.5 mg once a day, subjects aged 1 to 5 years received 1.25 mg once a day, and subjects 6 to 11 months of age received 1.0 mg once a day.

In subjects 6 to 11 years of age, no individual adverse event was reported by 2 percent or more of the subjects.

In subjects 2 to 5 years of age, adverse events reported for Des and placebo in at least 2 percent of subjects receiving Des

Oral Solution and at a frequency greater than placebo were fever (5.5%, 5.4%), urinary tract infection (3.6%, 0%) and varicella (3.6%, 0%).

In subjects 12 months to 23 months of age, adverse events reported for the Des product and placebo in at least 2 percent of subjects receiving Des

Oral Solution and at a frequency greater than placebo were fever (16.9%, 12.9%), diarrhea (15.4%, 11.3%), upper respiratory tract infections (10.8%, 9.7%), coughing (10.8%, 6.5%), appetite increased (3.1%, 1.6%), emotional lability (3.1%, 0%), epistaxis (3.1%, 0%), parasitic infection (3.1%, 0%), pharyngitis (3.1%, 0%), rash maculopapular (3.1%, 0%).

In subjects 6 months to 11 months of age, adverse events reported for Des and placebo in at least 2 percent of subjects receiving Des

Oral Solution and at a frequency greater than placebo were upper respiratory tract infections (21.2%, 12.9%), diarrhea (19.7%, 8.1%), fever (12.1%, 1.6%), irritability (12.1%, 11.3%), coughing (10.6%, 9.7%), somnolence (9.1%, 8.1%), bronchitis (6.1%, 0%), otitis media (6.1%, 1.6%), vomiting (6.1%, 3.2%), anorexia (4.5%, 1.6%), pharyngitis (4.5%, 1.6%), insomnia (4.5%, 0%), rhinorrhea (4.5%, 3.2%), erythema (3.0%, 1.6%), and nausea (3.0%, 0%).

There were no clinically meaningful changes in any electrocardiographic parameter, including the QTc interval. Only one of the 246 pediatric subjects receiving Des

Oral Solution in the clinical trials discontinued treatment because of an adverse event.

Post-Marketing Experience

Because adverse events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The following spontaneous adverse events have been reported during the marketing of Des: tachycardia, palpitations, rare cases of hypersensitivity reactions (such as rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis), psychomotor hyperactivity, movement disorders (including dystonia, tics, and extrapyramidal symptoms), seizures, and elevated liver enzymes including bilirubin, and very rarely, hepatitis.

Des contraindications

See also:
What is the most important information I should know about Des?

You should not take this medication if you are allergic to Des or to loratadine (Claritin).

Before taking Des, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

Do not give this medication to a child younger than 2 years old without the advice of a doctor.

Des disintegrating tablets (Des) may contain phenylalanine. Talk to your doctor before using this form of Des if you have phenylketonuria (PKU).

Active ingredient matches for Des:

Desloratadine in Bangladesh, India.


List of Des substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
DES - OD Capsule/ Tablet / 5mg / 10 units (Cadila Pharmaceuticals (Le Sante Division))$ 0.65
Des OD 5 mg x 10 Blister x 10 Tablet (Le Sante (Cadila Pharmaceuticals Ltd.))
Des OD 5 mg Tablet (Le Sante (Cadila Pharmaceuticals Ltd.))$ 0.07
DES OD 10 MG TABLET 1 strip / 10 tablets each (Le Sante (Cadila Pharmaceuticals Ltd.))$ 0.79
Des OD 10mg Tablet (Le Sante (Cadila Pharmaceuticals Ltd.))$ 0.09
Des-OD 5mg FC-TAB / 10 (Cadila (Le Sante))$ 0.57
5 mg x 10's (Cadila (Le Sante))$ 0.57
DES-OD film-coated tab 5 mg x 10's (Cadila (Le Sante))$ 0.57
Descare 5 mg Tablet (Azine Healthcare Pvt. Ltd.)$ 0.04
Deschu 5 mg
Desdin 5 mg (Lapi)
DESENT Capsule/ Tablet / 5mg / 10 units (Indoco Remedies Ltd)$ 0.25
Desent 5mg TAB / 10 (Indoco Remedies Ltd)$ 0.47
5 mg x 10's (Indoco Remedies Ltd)$ 0.47
Desent 5 mg Tablet (Indoco Remedies Ltd)$ 0.05
DESENT 5MG TABLET 1 strip / 10 tablets each (Indoco Remedies Ltd)$ 0.44
Desent 5mg TAB / 10 (Indoco Remedies Ltd)$ 0.47
Desent 5mg Tablet (Indoco Remedies Ltd)$ 0.04

References

  1. DailyMed. "DESLORATADINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "Desloratadine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "Desloratadine". http://www.drugbank.ca/drugs/DB00967 (accessed September 17, 2018).

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