Deviry Uses

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What is Deviry?

Deviry injection is used to prevent pregnancy. It is a birth control method that works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.

No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective than birth control pills. Discuss your options for birth control with your doctor.

Deviry does not prevent AIDS or other sexually transmitted diseases. It will not help as emergency contraception, such as after unprotected sexual contact.

Deviry injection is also used with other medicines to help relieve symptoms of inoperable, recurrent, and metastatic (cancer that has already spread) endometrial or kidney cancer.

Deviry is to be administered only by or under the immediate supervision of your doctor.

Deviry indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Deviry (MPA) Injectable Suspension, USP is indicated only for the prevention of pregnancy. The loss of bone mineral density (BMD) in women of all ages and the impact on peak bone mass in adolescents should be considered, along with the decrease in BMD that occurs during pregnancy and/or lactation, in the risk/benefit assessment for women who use MPA Injectable Suspension, USP long-term.

How should I use Deviry?

Use Deviry (subcutaneous) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Deviry (subcutaneous).

Uses of Deviry in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications

Abnormal uterine bleeding (tablet): Treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer.

Amenorrhea, secondary (tablet): Treatment of secondary amenorrhea due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer.

Contraception (104 mg per 0.65 mL and 150 mg/mL injection): Prevention of pregnancy in females of reproductive potential.

Endometrial hyperplasia prevention (tablet): Prevention of endometrial hyperplasia in nonhysterectomized postmenopausal persons receiving daily oral conjugated estrogens 0.625 mg. Note: Due to safety considerations, when a progesterone is needed, use of micronized progesterone is preferred over Deviry (AACE [Goodman 2011]; AACE/ACE [Cobin 2017])

Endometrial carcinoma (400 mg/mL injection) (100 mg tablet [Canadian product]): Adjunctive therapy and/or palliative treatment of inoperable, recurrent, and/or metastatic endometrial carcinoma.

Endometriosis (104 mg/0.65 mL injection): Management of endometriosis-associated pain.

Off Label Uses

Abnormal uterine bleeding, acute

Data from a randomized, open-label clinical study support the use of oral Deviry in the treatment of acute uterine bleeding in nonpregnant, hemodynamically stable premenopausal women requiring emergent medical intervention. Additional data may be necessary to further define the role of Deviry in the management of this condition.

Deviry description


Each mL of suspension (vial) contains medroxyprogesterone acetate 150 mg, polyethylene glycol 3350 28.9 mg, polysorbate 80 2.41 mg, sodium chloride 8.68 mg, methylparaben 1.37 mg, propylparaben 0.15 mg and water for injection.

Each mL of suspension (prefilled syringe) contains medroxyprogesterone acetate 150 mg, polyethylene glycol 3350 28.5 mg, polysorbate 80 2.37 mg, sodium chloride 8.56 mg, methylparaben 1.35 mg, propylparaben 0.147 mg and water for injection.

When necessary, pH is adjusted with sodium hydroxide or hydrochloric acid, or both.

Deviry is pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-,(6α).

Deviry contraceptive injection contains medroxyprogesterone acetate, a derivative of progesterone, as its active ingredient. Deviry is active by the parenteral and oral routes of administration. It is a white to off-white, odorless crystalline powder that is stable in air and that melts between 200°C and 210°C. It is freely soluble in chloroform, soluble in acetone and dioxane, sparingly soluble in alcohol and methanol, slightly soluble in ether, and insoluble in water.

Deviry dosage


Prevention of Pregnancy: The recommended dose is 150 mg of Deviry contraceptive injection every 3 months (13 weeks) administered by deep IM injection in the gluteal or deltoid muscle. Deviry should not be used as a long-term birth control method (ie, >2 years) unless other birth control methods are considered inadequate. Dosage does not need to be adjusted for body weight.

To ensure the patient is not pregnant at the time of the 1st injection, the 1st injection should be given only during the first 5 days of a normal menstrual period; only within the first 5-days postpartum if not breastfeeding; and if exclusively breastfeeding, only at the 6th postpartum week. If the time interval between injections is >13 weeks, the physician should determine that the patient is not pregnant before administering the drug. The efficacy of Deviry contraceptive injection depends on adherence to the dosage schedule of administration.

Switching from Other Methods of Contraception: When switching from other contraceptive methods, Deviry should be given in a manner that ensures continuous contraceptive coverage based upon the mechanism of action of both methods (eg, patients switching from oral contraceptives should have their 1st injection of Deviry on the day after the last active tablet or at the latest, on the day following the final inactive tablet).

Administration: Deviry contraceptive injection should be shaken just before use to ensure that the dose being administered represents a uniform suspension.

Deviry interactions

See also:
What other drugs will affect Deviry?

Changes in Contraceptive Effectiveness Associated with Co-Administration of Other Products: If a woman on hormonal contraceptives takes a drug or herbal product that induces enzymes, including CYP3A4, that metabolize contraceptive hormones, counsel her to use additional contraception or a different method of contraception. Drugs or herbal products that induce such enzymes may decrease the plasma concentrations of contraceptive hormones, and may decrease the effectiveness of hormonal contraceptives.

Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include barbiturates, bosentan, carbamazepine, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, St. John’s wort, and topiramate.

HIV-Protease Inhibitors and Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs): Significant changes (increase or decrease) in the plasma levels of progestin have been noted in some cases of co-administration of HIV-protease inhibitors. Significant changes (increase or decrease) in the plasma levels of the progestin have been noted in some cases of co-administration with NNRTIs.

Antibiotics: There have been reports of pregnancy while taking hormonal contraceptives and antibiotics, but clinical pharmacokinetic studies have not shown consistent effects of antibiotics on plasma concentrations of synthetic steroids.

Consult the labeling of all concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations.

Laboratory Test Interactions: The pathologist should be advised of progestin therapy when relevant specimens are submitted.

The following laboratory tests may be affected by progestins including Deviry contraceptive injection:

Plasma and urinary steroid levels are decreased (eg, progesterone, estradiol, pregnanediol, testosterone, cortisol).

Gonadotropin levels are decreased.

Sex-hormone binding globulin concentrations are decreased.

Protein-bound iodine and butanol extractable protein-bound iodine may increase. T3-uptake values may decrease.

Coagulation test values for prothrombin (Factor II) and Factors VII, VIII, IX and X may increase.

Sulfobromophthalein and other liver function test values may be increased.

The effects of Deviry on lipid metabolism are inconsistent. Both increases and decreases in total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol have been observed in studies.

Deviry side effects

See also:
What are the possible side effects of Deviry?

Clinical Trials Experience: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In the 2 clinical trials with Deviry, over 3900 women, who were treated for up to 7 years, reported the following adverse reactions, which may or may not be related to the use of Deviry. The population studied ranges in from 15-51 years, of which 46% were White, 50% non-White and 4.9% Unknown race. The patients received Deviry mg every 3-months (90 days). The median study duration was 13 months with a range of 1-84 months. Fifty eight percent (58%) of patients remained in the study after 13 months and 34% after 24 months.

Adverse reactions that were reported by >5% of subjects are: Body as a Whole*: Headache (16.5%), abdominal pain/discomfort (11.2%).

Metabolic/Nutritional*: Increased weight >10 lbs at 24 months (37.7%).

Nervous*: Nervousness (10.8%), dizziness (5.6%), decreased libido (5.5%).

Urogenital*: Menstrual irregularities [bleeding (57.3% at 12 months, 32.1% at 24 months), amenorrhea (55% at 12 months, 68% at 24 months)].

Adverse reactions that were reported between 1% and 5% of subjects are: Body as a Whole*: Asthenia/fatigue (4.2%), backache (2.2%), dysmenorrhea (1.7%), hot flashes (1%).

Digestive*: Nausea (3.3%), bloating (2.3%).

Metabolic/Nutritional*: Edema (2.2%).

Musculoskeletal*: Leg cramps (3.7%), arthralgia (1%).

Nervous*: Depression (1.5%), insomnia (1%).

Skin and Appendages*: Acne (1.2%), no hair growth/alopecia (1.1%), rash (1.1%).

Urogenital*: Leukorrhea (2.9%), breast pain (2.8%), vaginitis (1.2%).

*Body system represented from COSTART medical dictionary.

Adverse reactions leading to study discontinuation in ≥2% subjects are bleeding (8.2%), amenorrhea (2.1%), weight gain (2%).

Post-Marketing Experience: The following adverse reactions have been identified during post approval use of Deviry.

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

There have been cases of osteoporosis including osteoporotic fractures reported post-marketing in patients taking Deviry.

Adverse reactions reported during post-marketing experience are: Body as Whole*: Chest pain, Allergic reactions, fever, injection site pain, chills, axillary swelling.

Cardiovascular*: Syncope, tachycardia, thrombophlebitis, deep vein thrombosis, pulmonary embolus, varicose veins.

Digestive*: Appetite changes, gastrointestinal disturbances, jaundice, excessive thirst, rectal bleeding.

Hematologic and Lymphatic*: Anemia, blood dyscrasia.

Musculoskeletal*: Osteoporosis.

Nervous*: Paralysis, facial palsy, paresthesia, drowsiness.

Respiratory*: Dyspnea and asthma, hoarseness.

Skin and Appendages*: Hirsutism, excessive sweating and body odor, dry skin, scleroderma.

Urogenital*: Cervical and breast cancer, lack of return to fertility, unexpected pregnancy, prevention of lactation, changes in breast size, breast lumps or nipple bleeding, galactorrhea, melasma, chloasma, increased libido, uterine hyperplasia, genitourinary infections, vaginal cysts, dyspareunia.

Deviry contraindications

See also:
What is the most important information I should know about Deviry?

Known hypersensitivity to Deviry or any other ingredients of Deviry.

Known or suspected pregnancy or as a diagnostic test for pregnancy. Active thrombophlebitis, or current or past history of thromboembolic disorders, or cerebral vascular disease. Known or suspected malignancy of breast. Significant liver disease. Undiagnosed vaginal bleeding.

Deviry should not be used as a long-term birth control method (ie, >2 years) unless other birth control methods are considered inadequate.

Use in pregnancy: Deviry should not be administered during pregnancy.

Active ingredient matches for Deviry:

Medroxyprogesterone acetate in India.


Unit description / dosage (Manufacturer)Price, USD
10 mg x 10's$ 0.79
100 mg x 100's$ 4.44
Deviry 10mg TAB / 10$ 0.79
Deviry 100mg TAB / 100$ 4.44
Deviry 2.5 mg Tablet$ 0.02
Deviry 100 mg Tablet$ 0.44
Deviry 10 mg Tablet$ 0.09
DEVIRY 10 MG TABLET 1 strip / 30 tablets each (Torrent Pharmaceuticals Ltd)$ 2.65
DEVIRY 10 MG TABLET 1 strip / 10 tablets each (Torrent Pharmaceuticals Ltd)$ 0.94
DEVIRY 100 MG TABLET 1 strip / 10 tablets each (Torrent Pharmaceuticals Ltd)$ 0.96
DEVIRY 2.5 MG TABLET 1 strip / 10 tablets each (Torrent Pharmaceuticals Ltd)$ 0.22
DEVIRY tab 10 mg x 10's (Elder)$ 0.87
DEVIRY tab 100 mg x 10's (Elder)$ 4.44
Deviry 10mg TAB / 10$ 0.79
Deviry 100mg TAB / 100$ 4.44
Deviry 10mg Tablet (Torrent Pharmaceuticals Ltd)$ 0.09
Deviry 2.5mg Tablet (Torrent Pharmaceuticals Ltd)$ 0.02

List of Deviry substitutes (brand and generic names):

DEPRO tab 10 mg x 10's (Novaduo Pharma)$ 0.87
Dimple 150mg Injection (Mylan Pharmaceuticals Pvt Ltd)$ 2.78
Tablet; Oral; Medroxyprogesterone Acetate 10 mg
Tablet; Oral; Medroxyprogesterone Acetate 2.5 mg
Tablet; Oral; Medroxyprogesterone Acetate 5 mg
Dom-medroxyprogesterone tablet 5 mg (Dominion Pharmacal (Canada))
Dom-medroxyprogesterone tablet 10 mg (Dominion Pharmacal (Canada))
Dom-medroxyprogesterone tablet 2.5 mg (Dominion Pharmacal (Canada))
DUB 10 MG TABLET 1 strip / 10 tablets each (Unicure India Pvt Ltd)$ 0.47
10 mg x 10's (Dewcare Concept)$ 0.68
Dubloc 10mg TAB / 10 (Dewcare Concept)$ 0.68
Dubloc 10 mg Tablet (Dewcare Concept)$ 0.07
DUBLOC tab 10 mg x 10's (Dewcare Concept)$ 0.76
Dubloc 10mg TAB / 10 (Dewcare Concept)$ 0.68
ECOGEST-M tab 10 mg x 10's (Systemic)
Embryogen 10mg TAB / 10 (East West)$ 0.79
10 mg x 10's (East West)$ 0.79
EMBRYOGEN tab 10 mg x 10's (East West)$ 0.79
2.5 mg x 10's (Wyeth)$ 0.19
5 mg x 10's (Wyeth)$ 0.35
10 mg x 10's (Wyeth)$ 0.68
Empeea 2.5mg TAB / 10 (Wyeth)$ 0.19
Empeea 5mg TAB / 10 (Wyeth)$ 0.35
Empeea 10mg TAB / 10 (Wyeth)$ 0.68
EMPEEA 10MG TABLET 1 strip / 10 tablets each (Wyeth)$ 0.68
EMPEEA tab 2.5 mg x 10's (Wyeth)$ 0.19
EMPEEA tab 5 mg x 10's (Wyeth)$ 0.35
EMPEEA tab 10 mg x 10's (Wyeth)$ 0.68
Empeea 2.5mg TAB / 10 (Wyeth)$ 0.19
Empeea 5mg TAB / 10 (Wyeth)$ 0.35
Empeea 10mg TAB / 10 (Wyeth)$ 0.68
Empeea 10mg Tablet (Wyeth)$ 0.07
Enaf-150 150 mg/3 mL x 3 mL x 10's (Umeda)
Enaf-150 inj 150 mg/3 mL 3 mL x 10 x 1's (Umeda)
EXPROG-M tab 10 mg x 10's (Biocin)$ 0.87
Injectable; Injection; Medroxyprogesterone Acetate 200 mg / ml (Pharmacia & Upjohn)
Suspension; Oral; Medroxyprogesterone Acetate 500 mg / 5 ml (Pharmacia & Upjohn)
Tablet; Oral; Medroxyprogesterone Acetate 10 mg (Pharmacia & Upjohn)


  1. DailyMed. "MEDROXYPROGESTERONE ACETATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "Medroxyprogesterone acetate". (accessed September 17, 2018).
  3. DrugBank. "Medroxyprogesterone acetate". (accessed September 17, 2018).


The results of a survey conducted on for Deviry are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Deviry. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet

2 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by website users about whether the Deviry drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Not expensive2

11 consumers reported time for results

To what extent do I have to use Deviry before I begin to see changes in my health conditions?
As part of the reports released by website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Deviry. To get the time effectiveness of using Deviry drug by other patients, please click here.
5 days8
1 week2
1 day1

11 consumers reported age


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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