All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
Weight gain.
Headache.
Dizziness.
Feeling sleepy.
Feeling nervous and excitable.
Upset stomach or throwing up.
Cramps.
Bloating.
Lowered interest in sex.
Pimples (acne).
Feeling tired or weak.
Enlarged breasts.
Vaginal bleeding or spotting.
Belly pain.
Leg cramps.
Swelling.
Not able to sleep.
Period (menstrual) changes. Periods become less often or stop.
Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Side effects of Deviry in details
A side effect of any drug can be defined as the unwanted or undesired effect produced by the drug. The side effect can be major or in few medications minor that can be ignored. Side effects not only vary from drug to drug, but it also depends on the dose of the drug, the individual sensitivity of the person, brand or company which manufactures it. If side effects overweigh the actual effect of the medicine, it may be difficult to convince the patient to take the drug. Few patients get specific side effects to specific drugs; in that case, a doctor replaces the drug with another. If you feel any side effect and it troubles you, do not forget to share with your healthcare practitioner.
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Clinical Trials Experience: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In the 2 clinical trials with Deviry, over 3900 women, who were treated for up to 7 years, reported the following adverse reactions, which may or may not be related to the use of Deviry. The population studied ranges in from 15-51 years, of which 46% were White, 50% non-White and 4.9% Unknown race. The patients received Depo-Provera 150 mg every 3-months (90 days). The median study duration was 13 months with a range of 1-84 months. Fifty eight percent (58%) of patients remained in the study after 13 months and 34% after 24 months.
Adverse reactions that were reported by >5% of subjects are: Body as a Whole*: Headache (16.5%), abdominal pain/discomfort (11.2%).
Metabolic/Nutritional*: Increased weight >10 lbs at 24 months (37.7%).
Urogenital*: Menstrual irregularities [bleeding (57.3% at 12 months, 32.1% at 24 months), amenorrhea (55% at 12 months, 68% at 24 months)].
Adverse reactions that were reported between 1% and 5% of subjects are: Body as a Whole*: Asthenia/fatigue (4.2%), backache (2.2%), dysmenorrhea (1.7%), hot flashes (1%).
Digestive*: Nausea (3.3%), bloating (2.3%).
Metabolic/Nutritional*: Edema (2.2%).
Musculoskeletal*: Leg cramps (3.7%), arthralgia (1%).
Nervous*: Depression (1.5%), insomnia (1%).
Skin and Appendages*: Acne (1.2%), no hair growth/alopecia (1.1%), rash (1.1%).
Urogenital*: Leukorrhea (2.9%), breast pain (2.8%), vaginitis (1.2%).
*Body system represented from COSTART medical dictionary.
Adverse reactions leading to study discontinuation in ≥2% subjects are bleeding (8.2%), amenorrhea (2.1%), weight gain (2%).
Post-Marketing Experience: The following adverse reactions have been identified during post approval use of Deviry.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
There have been cases of osteoporosis including osteoporotic fractures reported post-marketing in patients taking Deviry.
Adverse reactions reported during post-marketing experience are: Body as Whole*: Chest pain, Allergic reactions, fever, injection site pain, chills, axillary swelling.
Skin and Appendages*: Hirsutism, excessive sweating and body odor, dry skin, scleroderma.
Urogenital*: Cervical and breast cancer, lack of return to fertility, unexpected pregnancy, prevention of lactation, changes in breast size, breast lumps or nipple bleeding, galactorrhea, melasma, chloasma, increased libido, uterine hyperplasia, genitourinary infections, vaginal cysts, dyspareunia.
What is the most important information I should know about Deviry?
Deviry may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Deviry with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Deviry may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker. If patches develop, consult your doctor about the use of sunscreen or protective clothing when your skin is exposed to the sun, sunlamps, or tanning booths.
Diabetes patients - Deviry may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Tell your doctor if you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight). You may need to stop taking Deviry or take other special precautions for a period of time.
Talk with your doctor regularly (eg, every 3 to 6 months) about whether you need to continue taking Deviry.
If you wear contact lenses and you develop problems with them, contact your doctor.
Deviry may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Deviry.
Lab tests and medical exams, including physicals and blood pressure, may be performed while you use Deviry. You should have breast and pelvic exams, and a Pap testat least once a year. You should also have periodic mammograms as determined by your doctor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Examine your breasts monthly as directed by your doctor. Report any lumps right away.
Use Deviry with caution in ELDERLY women; they may be more sensitive to its effects.
Deviry should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: Do not use Deviry if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Deviry is found in breast milk. If you are or will be breast-feeding while you take Deviry, check with your doctor. Discuss any possible risks to your baby.
Deviry contraindications
Contraindication can be described as a special circumstance or a disease or a condition wherein you are not supposed to use the drug or undergo particular treatment as it can harm the patient; at times, it can be dangerous and life threatening as well. When a procedure should not be combined with other procedure or when a medicine cannot be taken with another medicine, it is called Relative contraindication. Contraindications should be taken seriously as they are based on the relative clinical experience of health care providers or from proven research findings.
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Known hypersensitivity to Deviry or any other ingredients of Deviry.
Known or suspected pregnancy or as a diagnostic test for pregnancy. Active thrombophlebitis, or current or past history of thromboembolic disorders, or cerebral vascular disease. Known or suspected malignancy of breast. Significant liver disease. Undiagnosed vaginal bleeding.
Deviry should not be used as a long-term birth control method (ie, >2 years) unless other birth control methods are considered inadequate.
Use in pregnancy: Deviry should not be administered during pregnancy.
References
DailyMed. "MEDROXYPROGESTERONE ACETATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
DTP/NCI. "Medroxyprogesterone acetate: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
European Chemicals Agency - ECHA. "Medroxyprogesterone acetate: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Deviry are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Deviry. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
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