Pregnancy of Dexclorfeniramina in details
Maternal antihistamine use has generally not resulted in an increased risk of birth defects; however, information specific to Dexclorfeniramina is limited (Källén 2002). Dexclorfeniramina is the dextro-isomer of chlorpheniramine. Antihistamines may be used for the treatment of rhinitis, urticaria, and pruritus with rash in pregnant women (although second generation antihistamines may be preferred) (Murase 2014; Wallace 2008; Zuberbier 2014). Antihistamines are not recommended for treatment of pruritus associated with intrahepatic cholestasis in pregnancy (Ambros-Rudolph 2011; Kremer 2011).
Dexclorfeniramina breastfeeding
Dexclorfeniramina is excreted into human milk. Side effects of antihistamine use have been described as a higher risk in infants, newborns, and premature babies than in the general population. The manufacturer recommends that due to the potential for serious adverse reactions in the nursing infant, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
See references
References for pregnancy information
- Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 7th ed." Philadelphia, PA: Lippincott Williams & Wilkins (2005):
- "Product Information. Polaramine (Dexclorfeniramina)." Schering-Plough Corporation, Kenilworth, NJ.
References for breastfeeding information
- "Product Information. Polaramine (Dexclorfeniramina)." Schering-Plough Corporation, Kenilworth, NJ.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
