Dexedrine Spansule Uses

How old is patient?
sponsored

What is Dexedrine Spansule?

Dexedrine Spansule is used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy (uncontrollable desire for sleep or a sudden attack of deep sleep). It belongs to the group of medicines called central nervous system (CNS) stimulants.

Dexedrine Spansule works in the treatment of ADHD by increasing attention and decreasing restlessness in children and adults who are overactive, cannot concentrate for very long, or are easily distracted and impulsive. Dexedrine Spansule is used as part of a total treatment program that also includes social, educational, and psychological treatment.

Dexedrine Spansule is available only with a doctor's prescription. Prescriptions cannot be refilled. A new prescription must be obtained from your doctor each time you or your child needs Dexedrine Spansule.

Dexedrine Spansule indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
sponsored

Dexedrine Spansule Sulfate Tablets USP are indicated for:

1. Narcolepsy.

2. Attention Deficit Disorder with Hyperactivity, as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in pediatric patients (ages 3 to 16 years) with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. The diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted.

How should I use Dexedrine Spansule?

Use Dexedrine Spansule sustained-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Dexedrine Spansule sustained-release capsules.

Uses of Dexedrine Spansule in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
sponsored

Use: Labeled Indications

Attention-deficit/hyperactivity disorder: Treatment of attention-deficit/hyperactivity disorder as part of a total treatment program that typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in pediatric patients 3 to 16 years (IR tablet, oral solution) or 6 to 16 years (ER capsule).

Narcolepsy: Treatment of narcolepsy.

Dexedrine Spansule description

Dexedrine Spansule is a chiral compound. The racemic mixture can be divided into its optical antipodes: levo- and dextro-amphetamine. Dexedrine Spansule is the parent compound of its own structural class, comprising a broad range of psychoactive derivatives, e.g., MDMA (Ecstasy) and the N-methylated form, methamphetamine. Dexedrine Spansule is a homologue of phenethylamine.

Dexedrine Spansule dosage

Dexedrine Spansule Dosage

Applies to the following strength(s): 5 mg; 10 mg; 15 mg; 5 mg/5 mL; 2.5 mg; 7.5 mg; 20 mg; 30 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Narcolepsy

-Initial Dose: 10 mg orally per day

-Maintenance Dose: May raise daily dose in 10 mg increments at weekly intervals until optimal response is obtained.

Comments:

-The usual dose is 5 to 60 mg per day in divided doses, depending on the individual patient response.

-IR: Give the first dose on awakening; give 1 to 2 additional doses at intervals of 4 to 6 hours.

-ER/SR: May use this formulation for once-a-day dosage wherever appropriate.

Use: Narcolepsy treatment

Usual Pediatric Dose for Attention Deficit Disorder

Immediate-Release (IR):

Age 3 to 5 Years:

-Initial Dose: 2.5 mg orally per day

-Maintenance Dose: May raise daily dose in 2.5 mg increments at weekly intervals until optimal response is obtained.

IR and Extended-Release (ER)/Sustained-Release (SR):

Age 6 to 17 Years:

-Initial Dose: 5 mg orally 1 or 2 times a day

-Maintenance Dose: May raise daily dose in 5 mg increments at weekly intervals until optimal response is obtained.

-Maximum Dose: Only in rare cases will it be necessary to exceed 40 mg per day.

Comments:

-IR: Give the first dose on awakening; give 1 to 2 additional doses at intervals of 4 to 6 hours.

-ER/SR: May use this formulation for once-a-day dosage wherever appropriate.

-Where possible, occasionally interrupt drug administration to determine if continued therapy is required.

Use: As part of a total treatment program for Attention Deficit Hyperactivity Disorder (ADHD).

Usual Pediatric Dose for Narcolepsy

Age 6 to 11 Years:

-Initial Dose: 5 mg orally per day

-Maintenance Dose: May raise daily dose in 5 mg increments at weekly intervals until optimal response is obtained.

Age 12 Years and Older:

-Initial Dose: 10 mg orally per day

-Maintenance Dose: May raise daily dose in 10 mg increments at weekly intervals until optimal response is obtained.

Comments:

-The usual dose is 5 to 60 mg per day in divided doses, depending on the individual patient response.

-IR: Give the first dose on awakening; give 1 to 2 additional doses at intervals of 4 to 6 hours.

-ER/SR: May use this formulation for once-a-day dosage wherever appropriate.

-Narcolepsy rarely occurs in children under 12 years of age.

Use: Narcolepsy treatment

Renal Dose Adjustments

Data not available.

Liver Dose Adjustments

Data not available.

Dose Adjustments

Narcolepsy Patients: Reduce dosage if bothersome adverse reactions (e.g., insomnia, anorexia) appear.

Precautions

US BOXED WARNINGS:

-Due to the high abuse potential, this drug should be prescribed/dispensed sparingly and particular attention should be paid to subjects possibly obtaining this drug for non-therapeutic use or distribution to others.

-Administering this drug for prolonged periods of time should be avoided as it may lead to drug dependence.

-Drug misuse may cause sudden death and serious cardiovascular adverse events.

Long-term effects of amphetamines in children have not been well established.

-For ADHD treatment, the IR formulations are not recommended in patients younger than 3 years and the ER/SR formulation is not recommended in patients younger than 6 years.

-For narcolepsy treatment, all formulations of this drug are not recommended in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II

Dialysis

Data not available.

Other Comments

Administration Advice:

-Avoid late evening doses because of the potential for insomnia.

-Administer this drug at the lowest effective dosage, and individually adjust dosage.

-Take tablet doses at the same times on each day preferably with or immediately after meals.

Storage Requirements:

-Store this drug between 20 to 25 degrees Celsius (68 to 77 Fahrenheit) and dispense in a tight, light-resistant container.

General:

-Individual patient response to amphetamines varies widely: toxic symptoms can occur at doses as low as 2 mg but are rare with doses of less than 15 mg; 30 mg can produce severe reactions yet doses of 400 to 500 mg are not necessarily fatal.

-Overdosage: Management is largely symptomatic and may include gastric lavage, activated charcoal, a cathartic, and sedation; insufficient data is available to recommend the use of hemodialysis or peritoneal dialysis.

Monitoring:

-Cardiovascular: Blood pressure, heart rate, changes in fingers and toes

-General: Signs of abuse/dependence

-Musculoskeletal: Growth (height, weight, appetite)

-Psychiatric: New or worsening psychiatric disorders, including aggressive behavior/hostility, depression, psychosis, mania, and suicidal thoughts or behavior

Patient Advice:

-Avoid driving and other potentially dangerous activities such as operating machinery until you know how this drug affects you.

-Contact your healthcare provider if you experience any of the following on your fingers or toes during treatment: unexplained wounds, new numbness, pain, skin color change, or temperature sensitivity.

More about Dexedrine Spansule

Consumer resources

Professional resources

Related treatment guides

Dexedrine Spansule interactions

See also:
What other drugs will affect Dexedrine Spansule?

sponsored

Acidifying agents - Gastrointestinal acidifying agents (guanethidine,reserpine, glutamic acid HCl,ascorbic acid, fruit juices, etc.) lower absorption of amphetamines Urinary acidifying agents -(ammonium chloride, sodium acid phosphate, etc.) Increase the concentration of the ionized species of the amphetamine Primary excretion - Both Groups of agents lower blood levels and efficacy of amphetamines Adrenergic blockers - Adrenergic blockers are inhibited by amphetamines Alkalinizing agents -Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.)increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentate the actions of amphetamines Antidepressants, tricyclic - Ferndexs may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated MAO inhibitors - MAO antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism. This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other monoamines from adrenergic nerve endings, this can cause headaches and other signs of hypertensive crisis. A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results Antihistamines - Ferndexs may counteract the sedative effect of antihistamines Antihypertensives - Ferndexs may antagonize the hypotensive effects of antihypertensives Chlorpromazine - Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat amphetamine poisoning Ethosuximide - Ferndexs may delay intestinal absorption of ethosuximide Haloperidol - Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines Lithium carbonate - The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate Meperidine - Ferndexs pone the analgesic effect of meperidine Methenamine therapy - Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy Norepinephrine - Ferndexs enhance the adrenergic effect of norepinephrine Phenobarbital - Ferndexs may delay intestinal absorption of phenobarbital; co-administration of phenobarbital may produce a synergistic anticonvulsant action Phenytoin - Ferndexs may delay intestinal absorption of phenytoin; co-administration of phenytoin may produce a synergistic anticonvulsant action Propoxyphene - In cases of propoxyphene overdose, amphetamine CNS stimulation is potentiated and fatal convulsions can occur Veratrum alkaloids - Ferndexs inhibit the hypotensive effect of veratrum alkaloids Drug/Laboratory Test Interaction Ferndexs can cause a significant elevation in plasma corticosteroid levels. This increase is greatest in the evening Ferndexs may interfere with urinary steroid determinations.

Dexedrine Spansule side effects

See also:
What are the possible side effects of Dexedrine Spansule?

sponsored

Applies to Dexedrine Spansule: oral capsule extended release, oral solution, oral tablet

In addition to its needed effects, some unwanted effects may be caused by Dexedrine Spansule (the active ingredient contained in Dexedrine Spansule). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Dexedrine Spansule:

Rare

Incidence not known:

If any of the following symptoms of overdose occur while taking Dexedrine Spansule, get emergency help immediately:

Symptoms of overdose:

Minor Side Effects

Some of the side effects that can occur with Dexedrine Spansule may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:

Dexedrine Spansule contraindications

See also:
What is the most important information I should know about Dexedrine Spansule?

Do not use Dexedrine Spansule if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take Dexedrine Spansule before the MAO inhibitor has cleared from your body.

Do not use this medication if you are allergic to Dexedrine Spansule, or if you have hardened arteries (arteriosclerosis), heart disease, moderate to severe high blood pressure (hypertension), overactive thyroid, glaucoma, severe anxiety or agitation, or a history of drug or alcohol addiction.

Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects. Before taking Dexedrine Spansule, tell your doctor if you have any type of heart problems.

Do not give this medication to a child younger than 3 years old without the advice of a doctor.

Long-term use of Dexedrine Spansule can slow a child's growth. Tell your doctor if the child using this medication is not growing or gaining weight properly.

Dexedrine Spansule is a drug of abuse and may be habit-forming. Keep track of the amount of medicine used from each new bottle. You should be aware if anyone is using your medicine improperly or without a prescription. Using this medication improperly can cause death or serious side effects on the heart.



Active ingredient matches for Dexedrine Spansule:

Dextroamphetamine


Unit description / dosage (Manufacturer)Price, USD
Capsule, Sustained Release; Oral; Dextroamphetamine Sulfate 10 mg
Capsule, Sustained Release; Oral; Dextroamphetamine Sulfate 15 mg
Dexedrine Spansule capsule, extended release 5 mg/1 (Amedra Pharmaceuticals LLC (US))
Dexedrine Spansule capsule, extended release 10 mg/1 (Amedra Pharmaceuticals LLC (US))
Dexedrine Spansule capsule, extended release 15 mg/1 (Amedra Pharmaceuticals LLC (US))

List of Dexedrine Spansule substitutes (brand and generic names):

Tablet; Oral; Dextroamphetamine Sulfate 5 mg

References

  1. DailyMed. "DEXTROAMPHETAMINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "dextroamphetamine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "dextroamphetamine". http://www.drugbank.ca/drugs/DB01576 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Dexedrine Spansule are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dexedrine Spansule. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


Consumer reported time for results

No survey data has been collected yet


Consumer reported age

No survey data has been collected yet


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 28 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2024 ndrugs.com All Rights Reserved